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Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin

Year 2020, , 1 - 5, 22.06.2020
https://doi.org/10.46239/ejbcs.602877

Abstract

The genus Iris
L. (Iridaceae) is a member of geophytes with attractive flowers.
There are about 56 Iris taxa
growing in Turkey, 24 of which are endemic. A survey of the literature
indicates that the research carried out on
Iris species are focused on
the flavonoid and volatile compounds of the plant.



In present study, the dichloromethane and
methanol extracts prepared from the rhizomes of 47 Iris taxa growing in
Turkey were investigated for their in vitro cholinesterase inhibitory
effects
against acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE) which the enzymes linked to Alzheimer’s disease
s and antioxidant capacities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical
scavenging test as well.



The Iris extracts studied have been found
more active against BChE than AChE.
compared
with
100
μg/ml
galanthamine (89.29 ± 0.96 %) as reference, Iris kerneriana (coded as Y122) and Iris pseudacorus (coded as Y131)
methanol extracts had significant BChE inhibition effect (respectively, 80.22 ±
1.04 % and 53.06 ± 1.13 %) at concentration of 2
00 μg/ml. Among
tested samples, methanol extracts of I.
kerneriana
, I. lazica, I. pseudacorus and I. suaveolens have shown remarkable antioxidant activity at
concentration of 2 mg/ml
for DPPH compared with gallic acid.

Supporting Institution

TÜBİTAK

Project Number

KAMAG-110G007

Thanks

Turkish Scientific and Technological Research Council (TÜBİTAK) for financial source (Project code: KAMAG-110G007) was kindly acknowledged.

References

  • Atta-ur-Rahman, Nasım S, Baig I, Jahan IA, Sener B, Orhan I, Choudhary MI 2002. Isoflavonoid glycosides from the rhizomes of Iris germanica, Chemical and Pharmaceutical Bulletin, 50(8): 1100-1102.
  • Atta-ur-Rahman, Nasim S, Baig I, Orhan I, Sener B, Ayanoğlu F, Choudhary MI 2003. Isoflavonoid glycosides from the rhizomes of Iris germanica. Helvetica Chimica Acta, 86: 3354-3362.
  • Atta-ur-Rahman, Nasım S, Baig I, Sener B, Orhan I, Ayanoğlu F, Choudhary MI 2004. Two new isoflavonoids from the rhizomes of Iris soforana, Natural Product Research, 18(5): 465-471.
  • Blois MS 1958. Antioxidant determinations by the use of a stable free radical. Nature, 181: 1119-1200.
  • Ellman GL, Courtney KD, Andres V, Featherstone RM 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2): 88-95.
  • Güner A, 2012. Iris L. In: Güner A, Aslan S, Vural M, Babaş MT (Eds.), Türkiye Bitkileri Listesi (Damarlı Bitkiler). İstanbul: Nezahat Gökyiğit Botanic Garden and Floristic Research Society, pp. 535-540.
  • Hacıbekiroğlu I, Kolak U 2011. Antioxidant and antiocholinesterase constituents from the petroleum ether and chloroform extracts of Iris suaveolens. Phytotherapy Research, 25: 522-529.
  • Hacıbekiroğlu I, Kolak U 2015. Screening antioxidant and anticholinesterase potential of Iris albicans extracts. Arabian Journal of Chemistry, 8: 264-268.
  • Hatano T 1995. Constituents of natural medicines with scavenging effects on active oxygen species – Tannins and related polyphenols. Nature Medicine, 49(4): 357-363.
  • Howes MJR, Houghton PJ, Perry NSL 2003. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotheraphy Research, 17: 1-18.
  • Kaya E 2014. Geophytes of Turkey. Yalova: Atatürk Central Horticultural Research Institute, pp. 1-96.
  • Mocan A, Zengin G, Mollica A, Uysal A, Gunes E, Crisan G, Aktumsek A 2018. Biological effects and chemical characterization of Iris schachtii Markgr. extracts - A new source of bioactive constituents. Food and Chemical Toxicology, 112: 448-457.
  • Orhan I, Şener B, Hashimoto T, Asakawa Y, Özgüven M, Ayanoğlu F 2002. Iristectorone K, a novel monocyclic triterpene ester from Iris germanica rhizomes growing in Turkey. Fitoterapia, 73: 316-319.
  • Orhan I, Nasim S, Şener B, Ayanoğlu F, Özgüven M, Choudhary MI, Atta-ur-Rahman 2003. Two isoflavones and bioactivity spectrum of the crude extracts of Iris germanica rhizomes. Phytotherapy Research, 17: 575-577.
  • Sevim D, Senol FS, Gulpinar AR, Erdogan Orhan I, Kaya E, Kartal M, Sener B 2013. Discovery of potent in vitro neuroprotective effect of the seed extracts from seven Paeonia L. (peony) taxa and their fatty acid composition. Industrial Crops and Products, 49: 240-246.
  • Sevim D 2018. Pharmacognosic studies on some Iris L. species. Ph. D. Thesis, Ankara: Gazi Üniversity Institute of Health Sciences, pp. 1-219.
  • Singab ANB, Ayoub IM, El-Shazyl M, Korinek M, Wu T, Cheng Y, Chang F, Wu Y 2016. Shedding the light on Iridaceae - Ethnobotany, phytochemistry and biological activity. Industrial Crops and Products, 92: 308-335.
  • Ullah F, Ayaz M, Sadiq A, Hussain A, Ahmad S, Imran M, Zeb A 2016. Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var. florentina. Natural Product Research, 30(12): 1440-1444.
  • Wang H, Cui Y, Zhao C 2010. Flavonoids of the genus Iris (Iridaceae). Mini-Reviews in Medicinal Chemistry, 10: 643-661.
Year 2020, , 1 - 5, 22.06.2020
https://doi.org/10.46239/ejbcs.602877

Abstract

Project Number

KAMAG-110G007

References

  • Atta-ur-Rahman, Nasım S, Baig I, Jahan IA, Sener B, Orhan I, Choudhary MI 2002. Isoflavonoid glycosides from the rhizomes of Iris germanica, Chemical and Pharmaceutical Bulletin, 50(8): 1100-1102.
  • Atta-ur-Rahman, Nasim S, Baig I, Orhan I, Sener B, Ayanoğlu F, Choudhary MI 2003. Isoflavonoid glycosides from the rhizomes of Iris germanica. Helvetica Chimica Acta, 86: 3354-3362.
  • Atta-ur-Rahman, Nasım S, Baig I, Sener B, Orhan I, Ayanoğlu F, Choudhary MI 2004. Two new isoflavonoids from the rhizomes of Iris soforana, Natural Product Research, 18(5): 465-471.
  • Blois MS 1958. Antioxidant determinations by the use of a stable free radical. Nature, 181: 1119-1200.
  • Ellman GL, Courtney KD, Andres V, Featherstone RM 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2): 88-95.
  • Güner A, 2012. Iris L. In: Güner A, Aslan S, Vural M, Babaş MT (Eds.), Türkiye Bitkileri Listesi (Damarlı Bitkiler). İstanbul: Nezahat Gökyiğit Botanic Garden and Floristic Research Society, pp. 535-540.
  • Hacıbekiroğlu I, Kolak U 2011. Antioxidant and antiocholinesterase constituents from the petroleum ether and chloroform extracts of Iris suaveolens. Phytotherapy Research, 25: 522-529.
  • Hacıbekiroğlu I, Kolak U 2015. Screening antioxidant and anticholinesterase potential of Iris albicans extracts. Arabian Journal of Chemistry, 8: 264-268.
  • Hatano T 1995. Constituents of natural medicines with scavenging effects on active oxygen species – Tannins and related polyphenols. Nature Medicine, 49(4): 357-363.
  • Howes MJR, Houghton PJ, Perry NSL 2003. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotheraphy Research, 17: 1-18.
  • Kaya E 2014. Geophytes of Turkey. Yalova: Atatürk Central Horticultural Research Institute, pp. 1-96.
  • Mocan A, Zengin G, Mollica A, Uysal A, Gunes E, Crisan G, Aktumsek A 2018. Biological effects and chemical characterization of Iris schachtii Markgr. extracts - A new source of bioactive constituents. Food and Chemical Toxicology, 112: 448-457.
  • Orhan I, Şener B, Hashimoto T, Asakawa Y, Özgüven M, Ayanoğlu F 2002. Iristectorone K, a novel monocyclic triterpene ester from Iris germanica rhizomes growing in Turkey. Fitoterapia, 73: 316-319.
  • Orhan I, Nasim S, Şener B, Ayanoğlu F, Özgüven M, Choudhary MI, Atta-ur-Rahman 2003. Two isoflavones and bioactivity spectrum of the crude extracts of Iris germanica rhizomes. Phytotherapy Research, 17: 575-577.
  • Sevim D, Senol FS, Gulpinar AR, Erdogan Orhan I, Kaya E, Kartal M, Sener B 2013. Discovery of potent in vitro neuroprotective effect of the seed extracts from seven Paeonia L. (peony) taxa and their fatty acid composition. Industrial Crops and Products, 49: 240-246.
  • Sevim D 2018. Pharmacognosic studies on some Iris L. species. Ph. D. Thesis, Ankara: Gazi Üniversity Institute of Health Sciences, pp. 1-219.
  • Singab ANB, Ayoub IM, El-Shazyl M, Korinek M, Wu T, Cheng Y, Chang F, Wu Y 2016. Shedding the light on Iridaceae - Ethnobotany, phytochemistry and biological activity. Industrial Crops and Products, 92: 308-335.
  • Ullah F, Ayaz M, Sadiq A, Hussain A, Ahmad S, Imran M, Zeb A 2016. Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var. florentina. Natural Product Research, 30(12): 1440-1444.
  • Wang H, Cui Y, Zhao C 2010. Flavonoids of the genus Iris (Iridaceae). Mini-Reviews in Medicinal Chemistry, 10: 643-661.
There are 19 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Research Articles
Authors

Duygu Sevim 0000-0003-3987-2466

Bilge Şener This is me

Project Number KAMAG-110G007
Publication Date June 22, 2020
Acceptance Date January 7, 2020
Published in Issue Year 2020

Cite

APA Sevim, D., & Şener, B. (2020). Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin. Eurasian Journal of Biological and Chemical Sciences, 3(1), 1-5. https://doi.org/10.46239/ejbcs.602877
AMA Sevim D, Şener B. Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin. Eurasian J. Bio. Chem. Sci. June 2020;3(1):1-5. doi:10.46239/ejbcs.602877
Chicago Sevim, Duygu, and Bilge Şener. “Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin”. Eurasian Journal of Biological and Chemical Sciences 3, no. 1 (June 2020): 1-5. https://doi.org/10.46239/ejbcs.602877.
EndNote Sevim D, Şener B (June 1, 2020) Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin. Eurasian Journal of Biological and Chemical Sciences 3 1 1–5.
IEEE D. Sevim and B. Şener, “Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin”, Eurasian J. Bio. Chem. Sci., vol. 3, no. 1, pp. 1–5, 2020, doi: 10.46239/ejbcs.602877.
ISNAD Sevim, Duygu - Şener, Bilge. “Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin”. Eurasian Journal of Biological and Chemical Sciences 3/1 (June 2020), 1-5. https://doi.org/10.46239/ejbcs.602877.
JAMA Sevim D, Şener B. Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin. Eurasian J. Bio. Chem. Sci. 2020;3:1–5.
MLA Sevim, Duygu and Bilge Şener. “Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin”. Eurasian Journal of Biological and Chemical Sciences, vol. 3, no. 1, 2020, pp. 1-5, doi:10.46239/ejbcs.602877.
Vancouver Sevim D, Şener B. Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin. Eurasian J. Bio. Chem. Sci. 2020;3(1):1-5.