Tilmikosin Zehirliliği: Mini Derleme

Abstract

Tilmikosin sadece veteriner hekimlik için geliştirilmiş makrolid grubu antibiyotiktir. Ürünün kullanımı sığır, koyun, domuz, hindi ve tavuklarda onaylanmıştır. Etkili olduğu mikroorganizmalarda protein sentezini engelleyerek bakteriostatik etki gösterir. Bu hayvanlarda özellikle solunum sistemi enfeksiyonlarının tedavisinde kullanılır. Makrolid grubu antibiyotiklerin yan etkileri arasında tanımlanan kardiyotoksisite ise tilmikosinde oldukça belirgindir. Etiket dışı kullanımda veya kullanımı önerilen hayvanlarda deri altı dışı uygulamalarda ölüme kadar gidebilen kardiyotoksisiteye neden olabilmektedir. İnsanlar ise genellikle tilmikosine kazara maruz kalırlar ve ölümler gözlenebilmektedir. Veteriner ilaçlar arasında en fazla yan etki bildirilen ilaçlardan birisidir. Bu derlemede tilmikosinin insan ve hayvanlarda neden olduğu toksisitesi, mekanizması ve tedavi seçenekleri hakkında bilgi verilmeye çalışılmıştır.

Keywords

• Tilmikosin
• kardiyotoksisite
• zehirlilik

Tilmicosin Toxication: Mini Review

Abstract

Tilmicosin is a macrolide group antibiotic developed only for veterinary medicine. The use of the product is approved in cattle, sheep, pigs, turkeys and chickens. It shows bacteriostatic effect by inhibiting protein synthesis in microorganisms. They are especially used in the treatment of respiratory system infections in these animals. Cardiotoxicity, which is defined among the side effects of macrolide group antibiotics, is quite prominent in tilmicosin. It can cause cardiotoxicity and death, when non-subcutaneous applications in recommended animals or extra-label use. Humans can often be accidentally exposed to tilmikosin, and deaths can be observed. Tilmicosin is one of the most reported side effects among veterinary drugs. In this review, it could be tried to give information about the toxicity, mechanism and treatment options of tilmicosin in humans and animals.

Keywords

• Tilmicosin
• cardiotoxicity
• toxicity

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