Ruminantlarda Tildipirosin Kullanımı

Year 2020, Volume: 3 Issue: 1, 70 - 73, 22.06.2020

Devran Coşkun Enver Yazar

Abstract

Ruminantlarda solunum sistemi enfeksiyonları ciddi ekonomik kayıp ve ölüm nedenleri arasındadır. Hastalığın etkenleri olarak sıklıkla Mannheimia haemolytica, Pasteurella multocida ve Histophilus somni bulunur. Ruminantlarda en fazla antibiyotik kullanımı nedenleri arasında solunum sisitemi enfeksiyonları gelmektedir. Solunum sistemi enfeksiyonlarının tedavisinde farklı antibiyotik grupları kullanılabilmektedir. Bu antibiyotikler arasında amfenikoller, florokinolonlar, sefalosporinler ve makrolidler bulunur. Veteriner sahada makrolid antibiyotikler özellikle solunum sistemi enfeksiyonları ve ayak enfeksiyonları tedavisinde tercih edilir. Makrolid antibiyotiklerden tildipirosin sadece veteriner saha için üretilmiştir ve sığır ve domuzlarda solunum sistemi enfeksiyonlarının tedavisinde kullanımı için onaylanmıştır. Bu derlemede tildipirosinin ruminantlarda etkinliği, klinikte kullanımı ve yan etkileri hakkında bilgiler verilmeye çalışılmıştır.

Keywords

Tildipirosin, makrolid

References

• Akköse M, İzci C 2017. Koyun ve keçilerde digital dermatitis. Atatürk Üniversitesi Vet Bil Derg, 12(1):99-110.
• Anastasi E, Giguere S, Berghaus LJ, Hondalus MK, Willingham-Lane JM, MacArthur I, Cohen ND, Roberts MC, Vazquez-Boland JA 2015. Novel transferable erm(46) determinant responsible for emerging macrolide resistance in Rhodococcus equi. J Antimicrob Chemother, 70(12):3184-3190.
• Angell JW, Clegg SR, Sullivan LE, Duncan JS, Grove-White DH, Carter SD, Evans NJ 2015. In vitro susceptibility of contagious ovine digital dermatitis associated Treponema spp. isolates to antimicrobial agents in the UK. Vet Dermatol, 26(6):484-487.
• Bartram DJ, Moyaert H, Vanimisetti BH, Ramage CP, Reddick D, Stegemann MR 2016. Comparative efficacy of tulathromycin and tildipirosin for the treatment of experimental Mycoplasma bovis infection in calves. Vet Med Sci, 2(3):170-178.
• Berman J, Francoz D, Dubuc J, Buczinski S 2017. A randomised clinical trial of a metaphylactic treatment with tildipirosin for bovine respiratory disease in veal calves. BMC Vet Res, 13(1):176.
• Dik B, Bahcivan E, Faki HE, Uney K 2017. Tildipirosin may cause cardiotoxicity in sheep. Biomed Res, 28(19):8234-8239.
• Eckert E, Brown HE, Leslie KE, DeVries TJ, Steele MA 2015. Weaning age affects growth, feed intake, gastrointestinal development, and behavior in Holstein calves fed an elevated plane of nutrition during the preweaning stage. J Dairy Sci, 98:6315-6326.
• EMA (European Medical Agency) 2020a. https://www.ema.europa.eu/en/documents/mrl-report/tildipirosin-bovine-caprine-porcine-species-european-public-maximum-residue-limit-assessment-report_en.pdf, (erişim tarihi:10.03.20).
• EMA (European Medical Agency) 2020b. https://www.ema.europa.eu/en/documents/overview/zuprevo-epar-summary-public_en.pdf, (erişim tarihi:10.03.20).
• Hill TM, Quigley JD, Suarez-Mena FX, Dennis TS, Schlotterbeck RL 2018. Case Study: Control of respiratory disease in male Holstein calves with tildipirosin and effect on health and growth from 0 to 4 months of age. Profes Anim Sci, 34:118-123.
• Korkmaz Y 2019. Cardiac safety of macrolide antibiotics, 6th International Conference on Sustainable Agriculture and Environment October 3-5, 2019, City of Konya - Turkey.
• Lubbers BV, Turnidge J 2015. Antimicrobial susceptibility testing for bovine respiratory disease: getting more from diagnostic results. Vet J, 203(2):149-154.
• Magalhaes LQ, Baptista AL, Fonseca PA, Menezes GL, Nogueira GM, Headley SA, Fritzen JT, Alfieri AA, Saut JPE 2017. Use of metaphylactic protocols based on the risk to develop bovine respiratory diseases in feedlot cattle. Ciencia Rural, 47(8):1-6.
• Martin M, Kleinhenz M, Kleinhenz K, Reppert E, Blasi D, Parks T, Baysinger A, Hutcheson J, Coetzee J 2020. Comparison of the effect of tildipirosin administered alone or in combination with transdermal flunixin on the performance, health, activity, and well-being of transported feedlot calves on arrival at the feedlot. Transl Anim Sci, 4:452-459.
• Martin MS, Kleinhenz M, Kleinhenz K, Reppert E, Blasi D, Parks T, Baysinger A, Hutcheson J, Coetzee J 2019. A field study to investigate the effect of Zuprevo administered alone or in combination with banamine transdermal on the health and well-being of transported feedlot calves on arrival at the feedlot. J Anim Sci, 97(Supplement 2):1-6
• Mates CI, Spinu M, Sandru CD, Pall E, Niculae C, Niculae M 2016. Antimicrobial protocols in bovine respiratory disease complex – a review. Lucrari Stiintifice Medicina Veterinara, 49(3):100-106.
• Menge M, Rose M, Bohland C, Zschiesche E, Kilp S, Metz W, Allan M, Ropke R, Nurnberger M 2012. Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). J Vet Pharmacol Ther, 35(6):550-559.
• Michael GB, Eidam C, Kadlec K, Meyer K, Sweeney MT, Murray RW, Watts JL, Schwarz S 2012. Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica. J Antimicrob Chemother, 67(6):1555-1557.
• O'Connor AM, Hu D, Totton SC, Scott N, Winder CB, Wang B, Wang C, Glanville J, Wood H, White B, Larson R, Waldner C, Sargeant JM 2019. A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot. Anim Health Res Rev, 20(2):163-181.
• O'Connor AM, Wang C, Sargeant JM, White B, Larson R, Wang B, Waldner C, Wood H, Glanville JM 2018. What is the efficacy of metaphylaxis using antibiotics for the prevention of bovine respiratory disease in beef cattle? Veterinary Diagnostic and Production Animal Medicine Reports, 10.
• O'Connor AM, Yuan C, Cullen JN, Coetzee JF, da Silva N, Wang C 2016. A mixed treatment meta-analysis of antibiotic treatment options for bovine respiratory disease - An update. Prev Vet Med, 132:130-139.
• Olsen AS, Warrass R, Douthwaite S 2015. Macrolide resistance conferred by rRNA mutations in field isolates of Mannheimia haemolytica and Pasteurella multocida. J Antimicrob Chemother, 70(2):420-423.
• Pardona B, Alliet J,Boone R, Roelandt S, Valgaeren B, Depreza P 2015. Prediction of respiratory disease and diarrhea in veal calves based on immunoglobulin levels and the serostatus for respiratory pathogens measured at arrival. Prev Vet Med, 120:169-176.
• Politis AP, Vasileiou NGC, Ioannidi KS, Mavrogianni VS 2019. Treatment of bacterial respiratory infections in lambs. Small Rumin Res, 176:70-75.
• Pyorala S, Baptiste KE, Catry B, van Duijkeren E, Greko C, Moreno MA, Pomba MC, Rantala M, Ruzauskas M, Sanders P, Threlfall EJ, Torren-Edo J, Torneke K 2014. Macrolides and lincosamides in cattle and pigs: Use and development of antimicrobial resistance. Vet J, 200(2):230-923.
• Raghavan B, Erickson K, Kugadas A, Batra SA, Call DR, Davis MA, Foreyt WJ, Srikumaran S 2016. Role of carriers in the transmission of pneumonia in bighorn sheep (Ovis canadensis). Biol Open, 5(6):745-755.
• Stanford K, Zaheer R, Klima C, McAllister T, Peters D, Niu YD, Ralston B 2020. Antimicrobial resistance in members of the bacterial bovine respiratory disease complex isolated from lung tissue of cattle mortalities managed with or without the use of antimicrobials. Microorganisms, 8(2):E288.
• Teixeira AGV, McArt JAA, Bicalho RC 2017. Efficacy of tildipirosin metaphylaxis for the prevention of respiratory disease, otitis and mortality in pre-weaned Holstein calves. Vet J, 219:44-48.
• Theurer ME, Fox JT, Bryant LK, Nickell LS, Hutcheson JP 2018. Treatment efficacy of tildipirosin or tulathromycin for first treatment of naturally occurring bovine respiratory disease in a commercial feedlot. The Bovine Practitioner, 52(2):154-159.
• Windeyer MC, Timsit E, Barkema H 2017. Bovine respiratory disease in pre-weaned dairy calves: Are current preventative strategies good enough? Vet J, 224:16-17.
• Wood ME, Fox KA, Jennings-Gaines J, Killion HJ, Amundson S, Miller MW, Edwards WH 2017. How respiratory pathogens contribute to lamb mortality in a poorly performing bighorn sheep (ovis canadensis) herd. J Wildl Dis, 53(1):126-130.
• Yazar E 2018. Veteriner İlaç ve Aşı A’dan Z’ye, Nobel tıp yayınevi, Ankara, Türkiye.
• Yazar E, 2019. Kemoterapötikler, in: Veteriner İlaç Rehberi ve Tedavi El Kitabı, Ed: Yazar E, Nobel tıp kitabevi, Ankara, Türkiye.
• Zhao Y, Guo L, Li J, Fang B, Huang X, 2018. Molecular epidemiology, antimicrobial susceptibility, and pulsed-field gel electrophoresis genotyping of Pseudomonas aeruginosa isolates from mink. Can J Vet Res, 82(4):256-263.