One of the most important challenges in the fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by the ABCB1 gene in many organs, is one of the important factors involved in the development of drug resistance. P-gp is mainly involved in efflux of toxic substances such as xenobiotics from the cell. In addition to these, it also plays a role the efflux of drugs used in the treatment of cancer, the rate of success in cancer treatment reduces. Phenolic compounds are chemicals that are naturally synthesized in plants and have many biological activities, especially antioxidant and anticancer. In previous studies, it was determined that in addition to their anticancer activities, phenolics modulate the acquired drug resistance by inhibiting the expression and function of P-gp. In this review, phenolic compounds that play a role in breaking multi-drug resistance by inhibiting the activation and expression of P-gp are discussed.
Sikic, B. I., Fisher, G. A., Lum, B. L., Halsey, J., Beketic-Oreskovic, L., & Chen, G. (1997). Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer chemotherapy and pharmacology, 40(1), S13-S19.
Year 2022,
Volume: 5 Issue: (Ek sayı 1), 162 - 165, 30.12.2022
Sikic, B. I., Fisher, G. A., Lum, B. L., Halsey, J., Beketic-Oreskovic, L., & Chen, G. (1997). Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer chemotherapy and pharmacology, 40(1), S13-S19.
Yumrutaş, Ö., & Yumrutaş, P. (2022). Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1. Eurasian Journal of Biological and Chemical Sciences, 5((Ek sayı 1), 162-165. https://doi.org/10.46239/ejbcs.1130645
AMA
Yumrutaş Ö, Yumrutaş P. Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1. Eurasian J. Bio. Chem. Sci. December 2022;5((Ek sayı 1):162-165. doi:10.46239/ejbcs.1130645
Chicago
Yumrutaş, Önder, and Pınar Yumrutaş. “Phenolic Compounds That Modulate Multi Drug Resistance through Inhibiting of P-Glycoprotein Encoded by Gene ABCB1”. Eurasian Journal of Biological and Chemical Sciences 5, no. (Ek sayı 1) (December 2022): 162-65. https://doi.org/10.46239/ejbcs.1130645.
EndNote
Yumrutaş Ö, Yumrutaş P (December 1, 2022) Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1. Eurasian Journal of Biological and Chemical Sciences 5 (Ek sayı 1) 162–165.
IEEE
Ö. Yumrutaş and P. Yumrutaş, “Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1”, Eurasian J. Bio. Chem. Sci., vol. 5, no. (Ek sayı 1), pp. 162–165, 2022, doi: 10.46239/ejbcs.1130645.
ISNAD
Yumrutaş, Önder - Yumrutaş, Pınar. “Phenolic Compounds That Modulate Multi Drug Resistance through Inhibiting of P-Glycoprotein Encoded by Gene ABCB1”. Eurasian Journal of Biological and Chemical Sciences 5/(Ek sayı 1) (December 2022), 162-165. https://doi.org/10.46239/ejbcs.1130645.
JAMA
Yumrutaş Ö, Yumrutaş P. Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1. Eurasian J. Bio. Chem. Sci. 2022;5:162–165.
MLA
Yumrutaş, Önder and Pınar Yumrutaş. “Phenolic Compounds That Modulate Multi Drug Resistance through Inhibiting of P-Glycoprotein Encoded by Gene ABCB1”. Eurasian Journal of Biological and Chemical Sciences, vol. 5, no. (Ek sayı 1), 2022, pp. 162-5, doi:10.46239/ejbcs.1130645.
Vancouver
Yumrutaş Ö, Yumrutaş P. Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1. Eurasian J. Bio. Chem. Sci. 2022;5((Ek sayı 1):162-5.