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An overview of leech saliva and cosmetic potential

Year 2024, Volume: 7 Issue: 2, 178 - 185, 31.12.2024
https://doi.org/10.46239/ejbcs.1569164

Abstract

The therapeutic benefits of leech secretion have been known for centuries, and the potential of this substance in modern cosmetics is now attracting increasing interest. Leech secretion contains various bioactive compounds, including enzymes, peptides, and proteins. The bioactive components found in leech saliva, including anticoagulants, growth factors, and antimicrobial peptides, are responsible for leech saliva's effectiveness in increasing skin hydration, reducing inflammation, and promoting wound healing. To utilize their potential, it is imperative to sift through the skin area. This study reviews the available literature and research studies on the chemical properties of leech saliva and its use in cosmetic formulations. It highlights the bioactive compounds, their potential mechanisms of action, and their efficacy in cosmetic applications. The sources consulted include peer-reviewed articles, clinical studies, and industry reports. Data from these studies are synthesized to provide a comprehensive overview of the current state of knowledge. The findings suggest that leech saliva has significant potential as an ingredient in cosmeceutical products and offers new benefits for skin rejuvenation and repair. The review highlights the need for further research to optimize extraction processes, ensure product safety, and investigate additional applications. By advancing our understanding of leech saliva's chemical properties and mechanisms, future studies may facilitate the development of innovative skincare solutions and increase the efficacy of cosmetic formulations.

References

  • Abdualkader AM, Ghawi AM, Alaama M, Awang M, Merzouk A. 2013. Leech therapeutic applications. Indian J Pharm Sci. 75(2):127-37.
  • Alaama M, Kucuk O, Bilir B, Merzouk A, Ghawi AM, Yerer MB, Ahmado MA, Abdualkader AM, Helaluddin ABM. 2024. Development of leech extract as a therapeutic agent: A chronological review. Pharmacol Res - Mod Chin Med. 10:100355.
  • Alharbi MB. 2015. Different Types of Leeches for Medical Use in Surgery, Described by Ibn al Quff (630-685AH). Journal of Research on History of Medicine. 4(3):129-132.
  • Al-Waili N, Salom K, Al-Ghamdi A. 2011. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. Sci World J. 11(1):766-787.
  • Amani L, Motamed N, Mirabzadeh Ardakani M, Dehghan Shasaltaneh M, Malek M, Shamsa F, Fatemi E, Amin M. 2021. Semi-Solid Product of Medicinal Leech Enhances Wound Healing in Rats. Jundishapur J Nat Pharm Prod. 16(4):e113910.
  • Amani L, Fadaei F, Shams Ardakani M, Mirabzadeh Ardakani M, Sadati Lamardi SN, Shirbeigi L. 2020. Leech therapy in skin conditions from the viewpoints of Avicenna and modern medicine: Historical review, current applications, and future recommendations. Iran. J. Dermatol. 23(4): 168-175.
  • Amani L, Fadaei F, Shams Ardakani M, Mirabzadeh Ardakani M, Shirbeigi L. 2020 Treatment of Diabetic Foot Ulcer (DFU) with Pharmaceutical Product using Hirudo orientalis: A Case Report. J Adv Med Biomed Res. 28(129):225-229.
  • Anoym. 2005. Health Ministry, Republic of Turkey. Cosmetics regulation. Official Gazette, 2005, 23.
  • Arabacı B. 2023. ‘Pearls’ of the nineteenth-century: from therapeutic actors to global commodities medicinal leeches in the Ottoman Empire. Med. Hist. 67(2):128–47.
  • Ayhan H, Mollahaliloğlu S. 2018. Tıbbi Sülük Tedavisi: Hirudoterapi. Ankara Med J. 18(1):141-8
  • Ayhan H. 2020. Leech disinfection and leech saliva secretion (bioactive compounds). In: Parlakpınar H, editor. Hirudotherapy (medical leech application). Türki̇ye Kli̇ni̇kleri, Ankara, pp. 22-29.
  • Baskova IP, Ferner Z, Balkina AS, Kozin SA, Kharitonova OV, Zavalova LL, Zgoda VG. 2008. Steroids, histamine, and serotonin in the medicinal leech salivary gland secretion. Biochem. (Mosc.) Suppl. B: Biomed Chem. 2:215-25.
  • Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, Faulkner E, Gould C, Gemmen E, Dall T. 2006. The burden of skin diseases: 2004. J Am Acad Dermatol. 55(3):490–500.
  • Bobrovsky P, Manuvera V, Baskova I, Nemirova S., Medvedev A, Lazarev V. 2021. Recombinant destabilase from Hirudo medicinalis is able to dissolve human blood clots in vitro. Curr Issues Mol Biol. 43(3): 2068-2081.
  • Brito AMM, Oliveira V, Icimoto MY, Nantes-Cardoso IL. 2021. Collagenase Activity of Bromelain Immobilized at Gold Nanoparticle Interfaces for Therapeutic Applications. Pharmaceutics. 13(8):1143.
  • Campos ITN, Silva MM, Azzolini SS, Souza AF, Sampaio CAM, Fritz H, Tanaka AS. 2004. Evaluation of phage display system and leech-derived tryptase inhibitor as a tool for understanding the serine proteinase specificities. Arch Biochem Biophys. 425(1):87–94.
  • Caughey GH. 2016. Mast cell proteases as pharmacological targets. Eur J Pharmacol. 778:44-55.
  • Folkers PJ, Clore GM, Driscoll PC, Dodt J, Koehler S, Gronenborn AM. 1989. Solution structure of recombinant hirudin and the Lys-47. fwdarw. Glu mutants: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Biochem. 28(6): 2601-2617.
  • Habeshian KA, Cohen BA. 2020. Current Issues in the Treatment of Acne Vulgaris. Pediatrics. 145(2):225–230.
  • Haycraft JB. 1883. Iv. on the action of a secretion obtained from the medicinal leech on the coagulation of the blood. Proc. R. Soc. Lond. 36(228–231):478–87.
  • Jayant DS, Chandurkar SV. 2018. Role of Jalaukavacharan and Mahamanjisthadi kwath in the management of mukhadushika wsr to Acne Vulgaris-a case study. Int. J. Res.Granthaalayah. 6:30-31.
  • Jung H. 2020. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 47(04):297-300.
  • Junren C, Xiaofang X, Huiqiong Z, Gangmin L, Yanpeng Y, Xiaoyu C, Yuqing G, Yanan L, Yue Z, Fu P, Cheng P. 2021. Pharmacological activities and mechanisms of hirudin and its derivatives - A Review. Front Pharmacol. 12:660757.
  • Kumari P. 2023. Effect Of Jaloka (Leech Therapy) In Acne Vulgaris. World J Pharm Res. 12(9):158-1584.
  • Lalitha S, Anavarathan V, Mahalakshmi V, Periyasami D, Muthukumar NJ, Banumathi V. 2018. Effectiveness of Attai Vidal (leech therapy) on Naala Vibatha Karappan (stasis eczema). World J Pharm Sci. 6(12):129-34.
  • Lemke S, Vilcinskas A. 2020. European medicinal leeches—new roles in modern medicine. Biomedicines. 8(5):99.
  • Lent CM, Zundel D, Freedman E, Groome JR. 1991. Serotonin in the leech central nervous system: anatomical correlates and behavioral effects. J Comp Physiol A. 168(2):191-200.
  • Lieberman P. 2011. The basics of histamine biology. Ann Allergy Asthma Immunol. 106(2):S2-S5.
  • Liu Z, Zhao F, Huang Z, He B, Liu K, Shi F. Zhao Z, Lin G. 2024. A chromosome-level genome assembly of the non-hematophagous leech Whitmania pigra (Whitman 1884): identification and expression analysis of antithrombotic genes. Genes. 15(2):164.
  • Marin E, Kornilov DA, Bukhdruker SS, Aleksenko VA, Manuvera VA, Zinovev EV. Kovalev KV, Shevtsov MB, Talyzina AA, Bobrovsky PA, Kuzmichev PK, Mishin AV, Gushchin IY, Lazarev VN, Borshchevskiy VI. 2023. Structural insights into thrombolytic activity of destabilase from medicinal leech. Sci Rep. 13(1):6641.
  • Milam, EC, Rieder EA. 2021. An approach to cosmeceuticals. In Essential Psychiatry for the Aesthetic Practitioner; Wiley Online Library: Hoboken, NJ, USA. pp. 42–48.
  • Mohammad‐Zadeh LF, Moses L, Gwaltney‐Brant SM. 2008. Serotonin: A Review. J Vet Pharmacol The. 31(3):187–99.
  • Moriguchi T, Takai J. 2020. Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms. Genes Cells. 25(7):443-449.
  • Peng, Liu, Xinyuan Pan, and Guoqian Yin. 2015. Natural Hirudin Increases Rat Flap Viability by Anti‐Inflammation via PARs/p38/NF‐κB Pathway. Biomed Res Int. 1:597264.
  • Pourrahimi M, Abdi M, Ghods R. 2020. Complications of leech therapy. Avicenna J Phytomed. 10(3):222-234.
  • Pratap Shankar K, Rao Sd, Umar S, Gopalakrishnaiah V. 2014. A clinical trial for evaluation of leech application in the management of Vicarcikā (eczema). Ancient Science of Life. 33(4):236.
  • Pratt CH, King LE, Messenger AG, Christiano AM, Sundberg JP. 2017. Alopecia areata. Nat Rev Dis Primers. 3(1):1-17.
  • Rados. 2004. Beyond bloodletting: FDA gives leeches a medical makeover, FDA Consum. 38(5):9.
  • Ren K, Gong H, Huang J, Liu Y, Dong Q, He K. Tian L, Zhang F, Yu A, Wu C. 2021. Thrombolytic and anticoagulant effects of a recombinant staphylokinase-hirudin fusion protein. Thromb Res. 208:26-34.
  • Ring J. 1991. Angewandte Allergologie MMV. Medizin, München.
  • Ring J. 2015. Eczema–in the focus between dermatology and allergology. Allergo J Int. 24:129-142.
  • Sandilands EA, Crowe J, Cuthbert H, Jenkins PJ, Johnston NR, Eddleston M, Bateman DN, Webb DJ. 2013. Histamine‐induced vasodilatation in the human forearm vasculature. Br J Clin Pharmacol. 76(5):699–707.
  • Sawyer RT. 1986. Leech Biology and behaviour. Clarendan, Oxford.
  • Sawyer RT. 2013. History of the Leech Trade in Ireland, 1750–1915: Microcosm of a Global Commodity. Med. Hist. 57(3):420–41.
  • Schnebli HP, Liersch MH. 2021. Properties and therapeutic potential of eglin c. Elastin and Elastases, Volume II. CRC Press. pp.137-143.
  • Siddall ME, Min GS, Fontanella FM, Phillips AJ, Watson SC. 2011. Bacterial symbiont and salivary peptide evolution in the context of leech phylogeny. Parasitology. 138(13):1815-27.
  • Siddiqui SA, Mohammad A, Shoaib M, Sultana A. 2024. Harnessing The Healing Power Of Leeches In Eczema Care: A Case Report. Eur J Pharm Med Res. 11(8):384-388
  • Sig AK, Guney M, Uskudar Guclu A, Ozmen E. 2017. Medicinal leech therapy—an overall perspective. Integr. Med. Res. 6(4):337–43.
  • Söllner C, Mentele R, Eckerskorn C, Fritz H, Sommerhoff C.P. 1994. Isolation and characterization of hirustasin, an antistasin‐type serine‐proteinase inhibitor from the medical leech Hirudo medicinalis. Eur J Biochem. 219(3):937-943.
  • Sundaresan S, Migden MR, Silapunt S. 2017. Stasis Dermatitis: Pathophysiology, Evaluation, and Management. Am J Clin Dermatol. 18(3):383-390.
  • Suter S, Chevallier I. 1998. The effect of Eglin C on the function of human neutrophils in vitro. Biol Chem. 369(2):573–8.
  • Taylor M, Gonzalez M, Porter R. 2011. Pathways to inflammation: acne pathophysiology. Eur J Dermatol. 21(3):323-33.
  • Ünal K, Erol ME, Ayhan H. 2023. Literature review on the effectiveness of medicinal leech therapy in the wound healing. Ank. Med. J. 23(1):151–64.
  • Utevsky S, Zagmajster M, Trontelj P. 2014. Hirudo medicinalis Linnaeus, 1758. The IUCN Red List of Threatened Species 2014: https://doi.org/10.2305/IUCN.UK.2014-1.RLTS.T10190A21415816.en
  • Waghmare G. 2019. Medicinal Leech Therapy in Alopecia areata patchy (Khalitya)-A Case Report. International Journal of AYUSH Case Reports. 23(3): 206-211.
  • Waycaster C, Carter MJ, Gilligan AM, Mearns ES, Fife CE, Milne CT. 2018. Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers. J Comp Eff Res . 7(2):149–65.
  • Weber GC, Buhren BA, Schrumpf H, Wohlrab J, Gerber PA. 2019. Clinical applications of hyaluronidase. Adv Exp Med Biol. 255–77.
  • Whitaker IS, Izadi D, Oliver DW, Monteath G, Butler PE. 2004. Hirudo medicinalis and the plastic surgeon. Br J Plast Surg. 57(4):348–53.
  • Wollina U, Heinig B, Nowak A. 2016. Medical Leech Therapy (Hirudotherapy). Our Dermatol. Online. 7:91–96
  • Xu H, Timares L, Elmets CA. 2019. Host defenses in Skin. Clin. Immunol. 1: 273-283.
  • Yadav CR, Guguloth RA. 2017. Case Study of Leech Therapy (Jalaukavacharana) in Khalitya W.S.R. Alopecia. Int J Pharmacogn ChineseMed. 1(3): 000115.
  • Zabkowska E, Piotrowska A. 2019. Hirudotherapy in selected dermatological applications. Aesthetic Cosm. Med. 8:779–786.
  • Ząbkowska E, Czerwińska-Ledwig O, Bartnicka M, Piotrowska A. 2022. Case reports and experts opinions about current use of leech therapy in dermatology and cosmetology. Cosmetics. 9(6): 137.
  • Zavalova LL, Baskova IP, Lukyanov SA, Sass AV, Snezhkov EV, Akopov SB, Artamonova II, Archipova VS, Nesmeyanov VA, Kozlov DG, Benevolensky SV, Kiseleva VI, Poverenny AM, Sverdlov ED. 2000. Destabilase from the medicinal leech is a representative of a novel family of lysozymes. Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol. 1478(1):69–77.
  • Zhao F, Huang Z, He B, Liu K, Li J, Liu Z, Lin G. 2024. Comparative genomics of two Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis: With emphasis on antithrombotic genes and their corresponding proteins. Int J Biol Macromol. 270: 132278.
Year 2024, Volume: 7 Issue: 2, 178 - 185, 31.12.2024
https://doi.org/10.46239/ejbcs.1569164

Abstract

References

  • Abdualkader AM, Ghawi AM, Alaama M, Awang M, Merzouk A. 2013. Leech therapeutic applications. Indian J Pharm Sci. 75(2):127-37.
  • Alaama M, Kucuk O, Bilir B, Merzouk A, Ghawi AM, Yerer MB, Ahmado MA, Abdualkader AM, Helaluddin ABM. 2024. Development of leech extract as a therapeutic agent: A chronological review. Pharmacol Res - Mod Chin Med. 10:100355.
  • Alharbi MB. 2015. Different Types of Leeches for Medical Use in Surgery, Described by Ibn al Quff (630-685AH). Journal of Research on History of Medicine. 4(3):129-132.
  • Al-Waili N, Salom K, Al-Ghamdi A. 2011. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. Sci World J. 11(1):766-787.
  • Amani L, Motamed N, Mirabzadeh Ardakani M, Dehghan Shasaltaneh M, Malek M, Shamsa F, Fatemi E, Amin M. 2021. Semi-Solid Product of Medicinal Leech Enhances Wound Healing in Rats. Jundishapur J Nat Pharm Prod. 16(4):e113910.
  • Amani L, Fadaei F, Shams Ardakani M, Mirabzadeh Ardakani M, Sadati Lamardi SN, Shirbeigi L. 2020. Leech therapy in skin conditions from the viewpoints of Avicenna and modern medicine: Historical review, current applications, and future recommendations. Iran. J. Dermatol. 23(4): 168-175.
  • Amani L, Fadaei F, Shams Ardakani M, Mirabzadeh Ardakani M, Shirbeigi L. 2020 Treatment of Diabetic Foot Ulcer (DFU) with Pharmaceutical Product using Hirudo orientalis: A Case Report. J Adv Med Biomed Res. 28(129):225-229.
  • Anoym. 2005. Health Ministry, Republic of Turkey. Cosmetics regulation. Official Gazette, 2005, 23.
  • Arabacı B. 2023. ‘Pearls’ of the nineteenth-century: from therapeutic actors to global commodities medicinal leeches in the Ottoman Empire. Med. Hist. 67(2):128–47.
  • Ayhan H, Mollahaliloğlu S. 2018. Tıbbi Sülük Tedavisi: Hirudoterapi. Ankara Med J. 18(1):141-8
  • Ayhan H. 2020. Leech disinfection and leech saliva secretion (bioactive compounds). In: Parlakpınar H, editor. Hirudotherapy (medical leech application). Türki̇ye Kli̇ni̇kleri, Ankara, pp. 22-29.
  • Baskova IP, Ferner Z, Balkina AS, Kozin SA, Kharitonova OV, Zavalova LL, Zgoda VG. 2008. Steroids, histamine, and serotonin in the medicinal leech salivary gland secretion. Biochem. (Mosc.) Suppl. B: Biomed Chem. 2:215-25.
  • Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, Faulkner E, Gould C, Gemmen E, Dall T. 2006. The burden of skin diseases: 2004. J Am Acad Dermatol. 55(3):490–500.
  • Bobrovsky P, Manuvera V, Baskova I, Nemirova S., Medvedev A, Lazarev V. 2021. Recombinant destabilase from Hirudo medicinalis is able to dissolve human blood clots in vitro. Curr Issues Mol Biol. 43(3): 2068-2081.
  • Brito AMM, Oliveira V, Icimoto MY, Nantes-Cardoso IL. 2021. Collagenase Activity of Bromelain Immobilized at Gold Nanoparticle Interfaces for Therapeutic Applications. Pharmaceutics. 13(8):1143.
  • Campos ITN, Silva MM, Azzolini SS, Souza AF, Sampaio CAM, Fritz H, Tanaka AS. 2004. Evaluation of phage display system and leech-derived tryptase inhibitor as a tool for understanding the serine proteinase specificities. Arch Biochem Biophys. 425(1):87–94.
  • Caughey GH. 2016. Mast cell proteases as pharmacological targets. Eur J Pharmacol. 778:44-55.
  • Folkers PJ, Clore GM, Driscoll PC, Dodt J, Koehler S, Gronenborn AM. 1989. Solution structure of recombinant hirudin and the Lys-47. fwdarw. Glu mutants: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Biochem. 28(6): 2601-2617.
  • Habeshian KA, Cohen BA. 2020. Current Issues in the Treatment of Acne Vulgaris. Pediatrics. 145(2):225–230.
  • Haycraft JB. 1883. Iv. on the action of a secretion obtained from the medicinal leech on the coagulation of the blood. Proc. R. Soc. Lond. 36(228–231):478–87.
  • Jayant DS, Chandurkar SV. 2018. Role of Jalaukavacharan and Mahamanjisthadi kwath in the management of mukhadushika wsr to Acne Vulgaris-a case study. Int. J. Res.Granthaalayah. 6:30-31.
  • Jung H. 2020. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 47(04):297-300.
  • Junren C, Xiaofang X, Huiqiong Z, Gangmin L, Yanpeng Y, Xiaoyu C, Yuqing G, Yanan L, Yue Z, Fu P, Cheng P. 2021. Pharmacological activities and mechanisms of hirudin and its derivatives - A Review. Front Pharmacol. 12:660757.
  • Kumari P. 2023. Effect Of Jaloka (Leech Therapy) In Acne Vulgaris. World J Pharm Res. 12(9):158-1584.
  • Lalitha S, Anavarathan V, Mahalakshmi V, Periyasami D, Muthukumar NJ, Banumathi V. 2018. Effectiveness of Attai Vidal (leech therapy) on Naala Vibatha Karappan (stasis eczema). World J Pharm Sci. 6(12):129-34.
  • Lemke S, Vilcinskas A. 2020. European medicinal leeches—new roles in modern medicine. Biomedicines. 8(5):99.
  • Lent CM, Zundel D, Freedman E, Groome JR. 1991. Serotonin in the leech central nervous system: anatomical correlates and behavioral effects. J Comp Physiol A. 168(2):191-200.
  • Lieberman P. 2011. The basics of histamine biology. Ann Allergy Asthma Immunol. 106(2):S2-S5.
  • Liu Z, Zhao F, Huang Z, He B, Liu K, Shi F. Zhao Z, Lin G. 2024. A chromosome-level genome assembly of the non-hematophagous leech Whitmania pigra (Whitman 1884): identification and expression analysis of antithrombotic genes. Genes. 15(2):164.
  • Marin E, Kornilov DA, Bukhdruker SS, Aleksenko VA, Manuvera VA, Zinovev EV. Kovalev KV, Shevtsov MB, Talyzina AA, Bobrovsky PA, Kuzmichev PK, Mishin AV, Gushchin IY, Lazarev VN, Borshchevskiy VI. 2023. Structural insights into thrombolytic activity of destabilase from medicinal leech. Sci Rep. 13(1):6641.
  • Milam, EC, Rieder EA. 2021. An approach to cosmeceuticals. In Essential Psychiatry for the Aesthetic Practitioner; Wiley Online Library: Hoboken, NJ, USA. pp. 42–48.
  • Mohammad‐Zadeh LF, Moses L, Gwaltney‐Brant SM. 2008. Serotonin: A Review. J Vet Pharmacol The. 31(3):187–99.
  • Moriguchi T, Takai J. 2020. Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms. Genes Cells. 25(7):443-449.
  • Peng, Liu, Xinyuan Pan, and Guoqian Yin. 2015. Natural Hirudin Increases Rat Flap Viability by Anti‐Inflammation via PARs/p38/NF‐κB Pathway. Biomed Res Int. 1:597264.
  • Pourrahimi M, Abdi M, Ghods R. 2020. Complications of leech therapy. Avicenna J Phytomed. 10(3):222-234.
  • Pratap Shankar K, Rao Sd, Umar S, Gopalakrishnaiah V. 2014. A clinical trial for evaluation of leech application in the management of Vicarcikā (eczema). Ancient Science of Life. 33(4):236.
  • Pratt CH, King LE, Messenger AG, Christiano AM, Sundberg JP. 2017. Alopecia areata. Nat Rev Dis Primers. 3(1):1-17.
  • Rados. 2004. Beyond bloodletting: FDA gives leeches a medical makeover, FDA Consum. 38(5):9.
  • Ren K, Gong H, Huang J, Liu Y, Dong Q, He K. Tian L, Zhang F, Yu A, Wu C. 2021. Thrombolytic and anticoagulant effects of a recombinant staphylokinase-hirudin fusion protein. Thromb Res. 208:26-34.
  • Ring J. 1991. Angewandte Allergologie MMV. Medizin, München.
  • Ring J. 2015. Eczema–in the focus between dermatology and allergology. Allergo J Int. 24:129-142.
  • Sandilands EA, Crowe J, Cuthbert H, Jenkins PJ, Johnston NR, Eddleston M, Bateman DN, Webb DJ. 2013. Histamine‐induced vasodilatation in the human forearm vasculature. Br J Clin Pharmacol. 76(5):699–707.
  • Sawyer RT. 1986. Leech Biology and behaviour. Clarendan, Oxford.
  • Sawyer RT. 2013. History of the Leech Trade in Ireland, 1750–1915: Microcosm of a Global Commodity. Med. Hist. 57(3):420–41.
  • Schnebli HP, Liersch MH. 2021. Properties and therapeutic potential of eglin c. Elastin and Elastases, Volume II. CRC Press. pp.137-143.
  • Siddall ME, Min GS, Fontanella FM, Phillips AJ, Watson SC. 2011. Bacterial symbiont and salivary peptide evolution in the context of leech phylogeny. Parasitology. 138(13):1815-27.
  • Siddiqui SA, Mohammad A, Shoaib M, Sultana A. 2024. Harnessing The Healing Power Of Leeches In Eczema Care: A Case Report. Eur J Pharm Med Res. 11(8):384-388
  • Sig AK, Guney M, Uskudar Guclu A, Ozmen E. 2017. Medicinal leech therapy—an overall perspective. Integr. Med. Res. 6(4):337–43.
  • Söllner C, Mentele R, Eckerskorn C, Fritz H, Sommerhoff C.P. 1994. Isolation and characterization of hirustasin, an antistasin‐type serine‐proteinase inhibitor from the medical leech Hirudo medicinalis. Eur J Biochem. 219(3):937-943.
  • Sundaresan S, Migden MR, Silapunt S. 2017. Stasis Dermatitis: Pathophysiology, Evaluation, and Management. Am J Clin Dermatol. 18(3):383-390.
  • Suter S, Chevallier I. 1998. The effect of Eglin C on the function of human neutrophils in vitro. Biol Chem. 369(2):573–8.
  • Taylor M, Gonzalez M, Porter R. 2011. Pathways to inflammation: acne pathophysiology. Eur J Dermatol. 21(3):323-33.
  • Ünal K, Erol ME, Ayhan H. 2023. Literature review on the effectiveness of medicinal leech therapy in the wound healing. Ank. Med. J. 23(1):151–64.
  • Utevsky S, Zagmajster M, Trontelj P. 2014. Hirudo medicinalis Linnaeus, 1758. The IUCN Red List of Threatened Species 2014: https://doi.org/10.2305/IUCN.UK.2014-1.RLTS.T10190A21415816.en
  • Waghmare G. 2019. Medicinal Leech Therapy in Alopecia areata patchy (Khalitya)-A Case Report. International Journal of AYUSH Case Reports. 23(3): 206-211.
  • Waycaster C, Carter MJ, Gilligan AM, Mearns ES, Fife CE, Milne CT. 2018. Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers. J Comp Eff Res . 7(2):149–65.
  • Weber GC, Buhren BA, Schrumpf H, Wohlrab J, Gerber PA. 2019. Clinical applications of hyaluronidase. Adv Exp Med Biol. 255–77.
  • Whitaker IS, Izadi D, Oliver DW, Monteath G, Butler PE. 2004. Hirudo medicinalis and the plastic surgeon. Br J Plast Surg. 57(4):348–53.
  • Wollina U, Heinig B, Nowak A. 2016. Medical Leech Therapy (Hirudotherapy). Our Dermatol. Online. 7:91–96
  • Xu H, Timares L, Elmets CA. 2019. Host defenses in Skin. Clin. Immunol. 1: 273-283.
  • Yadav CR, Guguloth RA. 2017. Case Study of Leech Therapy (Jalaukavacharana) in Khalitya W.S.R. Alopecia. Int J Pharmacogn ChineseMed. 1(3): 000115.
  • Zabkowska E, Piotrowska A. 2019. Hirudotherapy in selected dermatological applications. Aesthetic Cosm. Med. 8:779–786.
  • Ząbkowska E, Czerwińska-Ledwig O, Bartnicka M, Piotrowska A. 2022. Case reports and experts opinions about current use of leech therapy in dermatology and cosmetology. Cosmetics. 9(6): 137.
  • Zavalova LL, Baskova IP, Lukyanov SA, Sass AV, Snezhkov EV, Akopov SB, Artamonova II, Archipova VS, Nesmeyanov VA, Kozlov DG, Benevolensky SV, Kiseleva VI, Poverenny AM, Sverdlov ED. 2000. Destabilase from the medicinal leech is a representative of a novel family of lysozymes. Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol. 1478(1):69–77.
  • Zhao F, Huang Z, He B, Liu K, Li J, Liu Z, Lin G. 2024. Comparative genomics of two Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis: With emphasis on antithrombotic genes and their corresponding proteins. Int J Biol Macromol. 270: 132278.
There are 65 citations in total.

Details

Primary Language English
Subjects Medical Biotechnology (Other)
Journal Section Review Articles
Authors

Fatma Çoruk 0009-0007-4523-9962

Sibel Kaymak

Hüseyin Ayhan

Nilufer Vural

Salih Mollahaliloğlu

Early Pub Date December 27, 2024
Publication Date December 31, 2024
Submission Date October 18, 2024
Acceptance Date December 12, 2024
Published in Issue Year 2024 Volume: 7 Issue: 2

Cite

APA Çoruk, F., Kaymak, S., Ayhan, H., Vural, N., et al. (2024). An overview of leech saliva and cosmetic potential. Eurasian Journal of Biological and Chemical Sciences, 7(2), 178-185. https://doi.org/10.46239/ejbcs.1569164
AMA Çoruk F, Kaymak S, Ayhan H, Vural N, Mollahaliloğlu S. An overview of leech saliva and cosmetic potential. Eurasian J. Bio. Chem. Sci. December 2024;7(2):178-185. doi:10.46239/ejbcs.1569164
Chicago Çoruk, Fatma, Sibel Kaymak, Hüseyin Ayhan, Nilufer Vural, and Salih Mollahaliloğlu. “An Overview of Leech Saliva and Cosmetic Potential”. Eurasian Journal of Biological and Chemical Sciences 7, no. 2 (December 2024): 178-85. https://doi.org/10.46239/ejbcs.1569164.
EndNote Çoruk F, Kaymak S, Ayhan H, Vural N, Mollahaliloğlu S (December 1, 2024) An overview of leech saliva and cosmetic potential. Eurasian Journal of Biological and Chemical Sciences 7 2 178–185.
IEEE F. Çoruk, S. Kaymak, H. Ayhan, N. Vural, and S. Mollahaliloğlu, “An overview of leech saliva and cosmetic potential”, Eurasian J. Bio. Chem. Sci., vol. 7, no. 2, pp. 178–185, 2024, doi: 10.46239/ejbcs.1569164.
ISNAD Çoruk, Fatma et al. “An Overview of Leech Saliva and Cosmetic Potential”. Eurasian Journal of Biological and Chemical Sciences 7/2 (December 2024), 178-185. https://doi.org/10.46239/ejbcs.1569164.
JAMA Çoruk F, Kaymak S, Ayhan H, Vural N, Mollahaliloğlu S. An overview of leech saliva and cosmetic potential. Eurasian J. Bio. Chem. Sci. 2024;7:178–185.
MLA Çoruk, Fatma et al. “An Overview of Leech Saliva and Cosmetic Potential”. Eurasian Journal of Biological and Chemical Sciences, vol. 7, no. 2, 2024, pp. 178-85, doi:10.46239/ejbcs.1569164.
Vancouver Çoruk F, Kaymak S, Ayhan H, Vural N, Mollahaliloğlu S. An overview of leech saliva and cosmetic potential. Eurasian J. Bio. Chem. Sci. 2024;7(2):178-85.