EXAMINATION OF NEUTROPHIL/LYMPHOCYTE (NLR), MONOCYTE/LYMPHOCYTE (MLR), AND PLATELET/LYMPHOCYTE (PLR) RATIOS BETWEEN ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA

Year 2023, , 102 - 106, 27.12.2023

Taylan Yavuz Bulut , Ahmet Şair

https://doi.org/10.55994/ejcc.1394602

Cited By: 1

Abstract

Background: The present study aims to investigate whether proinflammatory marker ratios in whole blood differ in these two dementia diseases.
Materials and Methods:
This study will involve Alzheimer's disease (AD) and vascular dementia (VaD) patients who were treated as outpatients in the outpatient clinic and inpatients in the ward of the Neurology Department of Adnan Menderes University Hospital. The patients’ diagnoses will be scanned in the hospital information system. The admission blood results of patients who presented between January 2018 and September 2020 will be included, and the patients’ hemogram results will be scanned retrospectively. Neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratios in the hemogram results will be calculated and recorded.
Results:
In the AD-VaD comparison of the patients participating in the study, a significant difference was identified between the variability of platelet/lymphocyte (PLR) and NLRs (NLR) (p<0.001). Moreover, a significant difference was found between the mean ages of patients with vascular dementia and those with Alzheimer's dementia (p<0.0001).
Conclusion:
While proinflammatory markers obtained secondary to inflammation are significant in AD since it is a chronic and progressive process, the use of these markers is limited due to the gradual course after an acute event in vascular dementia. Furthermore, there is a need for additional studies on peripheral blood cells to identify the potential prodromal biomarkers of AD.

Keywords

Alzheimer, NLR, proinflammatory markers, vascular dementia

Ethical Statement

Bu çalışmanın etik kurul onayı Aydın Adnan Menderes Üniversitesi Rektörlüğü Tıp Fakültesi Dekanlığı Girişimsel Olmayan Klinik Araştırmalar Etik Kurulu'nun 14.01.2021 tarihli 2020/209 karar nolu yazısı ile alınmıştır.

Supporting Institution

none

Thanks

none

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