EN
Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema
Abstract
Angioedema describes a non-dependent, non-pitting and transient edema caused by the accumulation of vasoactive substances in the circulation. These vasoactive substances increase vascular permeability, causing swelling of the deep dermal, submucosal or subcutaneous tissues of the face, lips, neck, extremities or gastrointestinal tract. Urticaria may or may not accompany this condition. Angioedema is generally mediated through two pathways: histamine-mediated and bradykinin-mediated. Histamine-mediated angioedema generally responds to standard therapeutic measures (such as antihistamines, steroids and epinephrine), whereas bradykinin-mediated angioedema can be more difficult to manage in emergency departments (ED). Here, we present a patient who presented to our ED with bradykinin-mediated ACE-I-associated dramatic angioedema clinic, did not respond to standard treatments, rapidly improved with fresh frozen plasma (FFP) administration and was discharged after 6 days of follow-up in the emergency critical intensive care unit.
Keywords
Ethical Statement
Disclaimer on financial support (grants): None
All authors have completed and submitted the ICMJE Form for Disclosure of Potential
Conflicts of Interest. The authors indicate no financial support or financial conflict of interest.
The authors have indicated they have no financial relationships with any company and no
external funding.
References
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- 2. Sangha L, Ravichander B, Egwom P, Mishagina I. What Is Next? - The Role of Fresh Frozen Plasma in Refractory Angioedema. Am J Respir Crit Care Med. 2023;207:A3061.
- 3. Karim MY, Masood A. Fresh-frozen plasma as a treatment for life-threatening ACE-inhibitor angioedema. Journal of Allergy and Clinical Immunology. 2002;109(2):370-1.
- 4. Kostis WJ, Shetty M, Chowdhury YS, Kostis JB. ACE Inhibitor-Induced Angioedema: a Review. Curr Hypertens Rep. 2018;20(7):55. doi: 10.1007/s11906-018-0859-x.
- 5. Beaudin J, Colancecco M, Dargin J, Hansen C. Administration of fresh frozen plasma in ACE inhibitor-induced angioedema does not reduce ICU or hospital length of stay. Chest. 2022;161(6):A12.
Details
Primary Language
English
Subjects
Emergency Medicine
Journal Section
Letter to Editor
Publication Date
September 5, 2024
Submission Date
April 17, 2024
Acceptance Date
September 2, 2024
Published in Issue
Year 2024 Volume: 6 Number: 2
APA
Güler, S., Üçöz Kocaşaban, D., Ata, M. A., Coşkun Yaş, S., & Günaydın, Y. K. (2024). Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema. Eurasian Journal of Critical Care, 6(2), 83-84. https://doi.org/10.55994/ejcc.1469585
AMA
1.Güler S, Üçöz Kocaşaban D, Ata MA, Coşkun Yaş S, Günaydın YK. Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema. Eurasian j Crit Care. 2024;6(2):83-84. doi:10.55994/ejcc.1469585
Chicago
Güler, Sertaç, Dilber Üçöz Kocaşaban, Mehmet Ali Ata, Secdegül Coşkun Yaş, and Yahya Kemal Günaydın. 2024. “Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema”. Eurasian Journal of Critical Care 6 (2): 83-84. https://doi.org/10.55994/ejcc.1469585.
EndNote
Güler S, Üçöz Kocaşaban D, Ata MA, Coşkun Yaş S, Günaydın YK (September 1, 2024) Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema. Eurasian Journal of Critical Care 6 2 83–84.
IEEE
[1]S. Güler, D. Üçöz Kocaşaban, M. A. Ata, S. Coşkun Yaş, and Y. K. Günaydın, “Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema”, Eurasian j Crit Care, vol. 6, no. 2, pp. 83–84, Sept. 2024, doi: 10.55994/ejcc.1469585.
ISNAD
Güler, Sertaç - Üçöz Kocaşaban, Dilber - Ata, Mehmet Ali - Coşkun Yaş, Secdegül - Günaydın, Yahya Kemal. “Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema”. Eurasian Journal of Critical Care 6/2 (September 1, 2024): 83-84. https://doi.org/10.55994/ejcc.1469585.
JAMA
1.Güler S, Üçöz Kocaşaban D, Ata MA, Coşkun Yaş S, Günaydın YK. Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema. Eurasian j Crit Care. 2024;6:83–84.
MLA
Güler, Sertaç, et al. “Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema”. Eurasian Journal of Critical Care, vol. 6, no. 2, Sept. 2024, pp. 83-84, doi:10.55994/ejcc.1469585.
Vancouver
1.Sertaç Güler, Dilber Üçöz Kocaşaban, Mehmet Ali Ata, Secdegül Coşkun Yaş, Yahya Kemal Günaydın. Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema. Eurasian j Crit Care. 2024 Sep. 1;6(2):83-4. doi:10.55994/ejcc.1469585