Use of Fresh Frozen Plasma in a Dramatic Case of ACE-Inhibitor Associated Angioedema

Year 2024, Volume: 6 Issue: 2, 83 - 84, 05.09.2024

Sertaç Güler , Dilber Üçöz Kocaşaban , Mehmet Ali Ata , Secdegül Coşkun Yaş , Yahya Kemal Günaydın

https://doi.org/10.55994/ejcc.1469585

https://izlik.org/JA73BJ73MR

Abstract

Angioedema describes a non-dependent, non-pitting and transient edema caused by the accumulation of vasoactive substances in the circulation. These vasoactive substances increase vascular permeability, causing swelling of the deep dermal, submucosal or subcutaneous tissues of the face, lips, neck, extremities or gastrointestinal tract. Urticaria may or may not accompany this condition. Angioedema is generally mediated through two pathways: histamine-mediated and bradykinin-mediated. Histamine-mediated angioedema generally responds to standard therapeutic measures (such as antihistamines, steroids and epinephrine), whereas bradykinin-mediated angioedema can be more difficult to manage in emergency departments (ED). Here, we present a patient who presented to our ED with bradykinin-mediated ACE-I-associated dramatic angioedema clinic, did not respond to standard treatments, rapidly improved with fresh frozen plasma (FFP) administration and was discharged after 6 days of follow-up in the emergency critical intensive care unit.

Keywords

angioedema, fresh frozen plasma, emergency medicine

Ethical Statement

Disclaimer on financial support (grants): None All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. The authors indicate no financial support or financial conflict of interest. The authors have indicated they have no financial relationships with any company and no external funding.

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