Evaluation of Anaphylaxis Patients Admitted to the Emergency Department

Abstract

Anaphylaxis is a life-threatening allergic reaction requiring rapid diagnosis and treatment, with epinephrine being the first-line treatment to manage symptoms and prevent complications. This study aims to increase awareness by evaluating anaphylaxis cases in the emergency department to guide patients and physicians in managing the condition. This retrospective study, conducted at Bezmialem Vakıf University Hospital between 2018 and 2022, evaluated adult anaphylaxis patients using the National Institute of Allergy and Infectious Disease 2021 guideline. Patients' demographic and clinical data were analyzed, with ethics committee approval obtained for the study. Of the 77 patients studied, 9 required IV epinephrine treatment. More than half of the patients were started on epinephrine within 1 hour of exposure to the allergen. And the only person who was arrested had more than 1 hour to reach epinephrine treatment. When diagnosing anaphylaxis, we should not hesitate to start adrenaline and switch to IV infusion, and we should get the patient to the necessary care and treatment as soon as possible.

Keywords

• Anaphylaxis
• Emergency
• Epinephrine

Supporting Institution

nope

Project Number

yok

References

1. 1 Kelly McHugh, Zachary Repanshek, Anaphylaxis: Emergency Department Treatment Immunology and Allergy Clinics of North America Volume 43, Issue 3, 2023,Pages 453-466,ISSN 0889-8561,ISBN 9780443129759,https://doi.org/10.1016/j.iac.2022.10.002.
2. 2. Yocum MW, Butterfield JH, Klein JS, Volcheck GW, Schroeder DR, Silverstein MD. Epidemiology of anaphylaxis in Olmsted County: A population-based study. J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):452-6. doi: 10.1016/s0091-6749(99)70392-1. PMID: 10452770.
3. 3. Lieberman P. Biphasic anaphylactic reactions. Ann Allergy Asthma Immunol. 2005 Sep;95(3):217-26; quiz 226, 258. doi: 10.1016/S1081-1206(10)61217-3. PMID: 16200811.
4. 4. Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol. 2007 Apr;119(4):1016-8. doi: 10.1016/ j.jaci.2006.12.622. Epub 2007 Feb 15. PMID: 17306354.
5. 5. Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL. Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study. J Allergy Clin Immunol Pract. 2020 Apr;8(4):1230-1238. doi: 10.1016/j.jaip.2019.10.027. Epub 2019 Nov 6. PMID: 31704438.
6. 6. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy. 2000 Aug;30(8):1144-50. doi: 10.1046/j.1365-2222.2000.00864.x. PMID: 10931122.