Inflammatory markers and blood gas analysis in determining the severity of Chronic Obstructive Pulmonary Disease

Abstract

Abstract Aim: This study aimed to evaluate the severity of the disease using inflammatory markers in patients with Chronic Obstructive Pulmonary Disease (COPD) who admitted to the emergency department. Materials and Methods: 193 COPD patients who applied to the emergency department were included in this retrospective study. Patients were divided into two groups according to the severity of COPD. The presence of type 1 and type 2 respiratory failure was used to create Group 2 (severe, very severe, life-threatening) and in the absence, Group 1 (mild, moderate). Inflammatory markers such as Neutrophil / lymphocyte ratio (NLR), Platelet / lymphocyte ratio (PLR), Lymphocyte / monocyte ratio (LMR) and disease severity were evaluated for both groups. Results: The high COPD severity group (Group 2) had higher NLR and PLR values (p <0.001, p <0.001, respectively), and LMR values were lower (p <0.001). There was infection in 46.2% of Group 2, while this rate was 13.5% in Group 1 (p <0.001). Conclusion: As the severity of the disease increases, NLR, PLR values increase, and LMR value decreases. This indicates that COPD attack will be severe in the presence of infection in COPD patients.

Keywords

• Blood gas analysis
• emergency medicine
• inflammatory markers
• chronic obstructive pulmonary disease (COPD)

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