Paraoxonase Activity In Patients With Chronic Obstructive Pulmonary Disease

Abstract

Aim: We aimed to study the Paraoxonase 1 (PON1) activity in chronic obstructive pulmonary disease (COPD) patients with stable condition, had acute attack and developed respiratory failure. Material and Method: Twenty-five patients with stable COPD (group1) (mean age 62.9±9.4), 25 cases with acute COPD attack (group2) (mean age 63.8±9.0), 25 patients with hypercapnic respiratory failure (group3) (mean age 65.0±12.9) and 25 healthy individuals for control group (mean age 34.8±9.8), totally 100 cases, were enrolled to the study. Cases with secondary lipid disorder, cardiovascular disease, diabetes mellitus, renal failure, malignancy, hepatic failure and patients who receive antilipidemic or antioxidant medicines were not included to the study. All cases enrolled to the study underwent routine biochemical analysis including PON1 activity and lipid profile. Results: There was significant difference between groups with respect to PON1 levels (p<0.0001). PON1 activities of COPD patient groups (group 1=96.8±57.4U/L; group 2=51.4±32.8U/L; group 3=47.1±27.5U/L) were lower than control group (185.4±110.1U/L) (p<0.0001). Also, PON1 activity of stable COPD patients was higher than the COPD cases admitted with acute attack or respiratory failure (group2 and 3) (p<0.05). Conclusion: These findings show that PON1 activity may have a role in COPD pathogenesis and endogen antioxidants might be depleted by increased oxidative stress in COPD. This also advocates that oxidative stress may have a role in acute COPD attacks.

Keywords

• COPD
• oxidative stress
• Paraoxonase

References

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