Acute Phase Response

Abstract

We have read the article titled “The Role of C-RP / Albumin Ratio in The Diagnosis of Stroke and an Overview of the Factors Affecting Hemispheres” prepared by Tataroğlu and Güven with great interest1. We thank the authors and the editorial board for their courage in publishing this negative article that is informative and successful manuscript. As mentioned in an article published in nature, highlighting negative results will improve science2. We also would like to mention a few important points about systemic effects of inflammation and acute phase reactants.

Keywords

• Acute-Phase Reaction
• C-Reactive Protein
• Albumin

References

1. 1. Tataroğlu Ö, Güven O. The Role of C-RP / Albumin Ratio in The Diagnosis of Stroke and an Overview of the Factors Affecting Hemispheres. Eurasian J Crit Care. 2021; 3(2): 56-60.
2. 2. Mehta D. Highlight negative results to improve science. Nature. 2019 Oct 4. doi: 10.1038/d41586-019-02960-3. Epub ahead of print. PMID: 33009522.
3. 3. Özdemir S, Akça HŞ, Algın A, Eroğlu SE. Can C-reactive protein-to-albumin ratio be a predictor of short-term mortality in community-acquired pneumonia? Ann Clin Anal Med 2021;12(9):1043-1048.
4. 4. Gruys E, Toussaint MJ, Niewold TA, Koopmans SJ. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B. 2005;6(11):1045-1056.
5. 5. Salini V, Conti P. Inflammatory markers: serum amyloid A, fibrinogen and C-reactive protein – a revisited study. Eur J Inflamm 2011; 9:95-102.
6. 6. Ceciliani F, Giordano A, Spagnolo V. The systemic reaction during inflammation: the acute-phase proteins. Protein Pept Lett. 2002 Jun;9(3):211-23.
7. 7. Choudhuri S, Chowdhury IH, Saha A, Mitra B, Dastidar R, Roy PK. Acute monocyte pro inflammatory response predicts higher positive to negative acute phase reactants ratio and severe hemostatic derangement in dengue fever. Cytokine. 2021 Oct;146:155644