THE FILES OF PATIENTS WHO WERE DIAGNOSED WITH DRUG INTOXICATION, RESEARCH LABORATORY ANALYSIS

Abstract

Objective: In this study, we aimed to evaluate the relationship between laboratory electrolyte disturbances and drugs taken in poisoning cases who applied to the Emergency Department and took drugs for suicidal purposes. Materials and Methods: This study is a retrospective study. Patients aged 18 years and older who were diagnosed with drug poisoning in the Adult Emergency Clinic of Okmeydanı Training and Research Hospital Emergency Medicine Clinic were included in the study. Data analysis was done in SPSS 15.0 program. The significance level was taken as p<0.05. Results: 162 patients were included in the study. The mean age of the patients was 27 (range 18-61) years. Thirty-four (20.99%) of the patients were male. Considering the frequency of the drugs taken, 34 (21.1%) of the patients had NSAIDs (most common), 33 (20.5%) had paracetamol and/or its compounds, 29 (17.7%) had SSRI, had TCA, 149 (55.3%) had other drugs. It was observed that the serum Na values of the patients who took and did not take high-dose NSAIDs changed statistically (p=0.000). The laboratory test results of the patients who took and did not take these drugs were compared, and no statistically significant difference was found (p>0.05). Conclusion: According to our suicidal study findings, the amount of drugs taken by our patients is not correlated with their blood levels. Although more than half of our patients have taken toxic doses of the drugs, most of the poisonings are mild and our results can not be generalized to severe poisoning cases.

Keywords

• paracematol
• selective serotonin reuptake inhibitors
• nonsteroidal anti-inflammatory drugs
• tricyclic antidepressants
• drug intoxication

References

1. 1. Jayakrishnan B, Al Asmi A, Al Qassabi A, Nandhagopal R, Mohammed I. Acute drug overdose: clinical profile, etiologic spectrum and determinants of duration of intensive medical treatment. Oman Med J. 2012;27(6):501-504. doi:10.5001/omj.2012.120
2. 2. Akkose S, Bulut M, Armagan E, Cebicci H, Fedakar R. Acute poisoning in adults in the years 1996-2001 treated in the Uludag University Hospital, Marmara Region, Turkey. Clin Toxicol (Phila). 2005;43(2):105-109.
3. 3. Ozköse Z, Ayoglu F. Etiological and demographical characteristics of acute adult poisoning in Ankara, Turkey. Hum Exp Toxicol. 1999;18(10):614-618. doi:10.1191/096032799678839446
4. 4. Seydaoglu G, Satar S, Alparslan N. Frequency and mortality risk factors of acute adult poisoning in Adana, Turkey, 1997-2002. Mt Sinai J Med. 2005;72(6):393-401.
5. 5. Satar S, Seydaoglu G, Akpinar A, et al. Trends in acute adult poisoning in a ten-year period in Turkey: factors affecting the hazardous outcome. Bratisl Lek Listy. 2009;110(7):404-411.
6. 6. Saglam Z , Ataoglu E, Yenigün M, et al., Causes of acute poisoning in adults: a retrospective study, in a hospital in Istanbul, Turkey. Journal of Public Health, 2012. 20(1): p. 59-63.
7. 7. Anthony L, Kulkarni C. Patterns of poisoning and drug overdosage and their outcome among in-patients admitted to the emergency medicine department of a tertiary care hospital. Indian J Crit Care Med. 2012;16(3):130-135. doi:10.4103/0972-5229.102070
8. 8. Özayar, E.D. Semih; Güleç, Handan; Şahin, et all. Retrospective Analysis of Intoxication Cases in the ICU. Turkish Journal of Medical & Surgical Intensive Care Medicine, 2011(3): p. 59. doi:10.5152/dcbybd.2011.13

9. 9. Mak KK, Ho CS, Zhang MW,et all. Characteristics of overdose and non-overdose suicide attempts in a multi-ethnic Asian society. Asian Journal of Psychiatry. 2013 Oct;6(5):373-379. DOI: 10.1016/j.ajp.2013.03.011.
10. 10. Williams-Johnson J, Williams E, Gossell-Williams M, Sewell CA, Abel WD, Whitehorne-Smith PA. Suicide attempt by self-poisoning: characteristics of suicide attempters seen at the Emergency Room at the University Hospital of the West Indies. West Indian Med J. 2012;61(5):526-531. doi:10.7727/wimj.2012.209.
11. 11. Shah R, Uren Z, Baker A, Majeed A. Trends in suicide from drug overdose in the elderly in England and Wales, 1993-1999. Int J Geriatr Psychiatry. 2002;17(5):416-421. doi:10.1002/gps.625
12. 12. Akkas M, Coskun F, Ulu N, Sivri B. An epidemiological evaluation of 1098 acute poisoning cases from Turkey. Vet Hum Toxicol. 2004;46(4):213-215.
13. 13. Wharam PC, Speedy DB, Noakes TD, Thompson JM, Reid SA, Holtzhausen LM. NSAID use increases the risk of developing hyponatremia during an Ironman triathlon [published correction appears in Med Sci Sports Exerc. 2006 Jul;38(7):1364]. Med Sci Sports Exerc. 2006;38(4):618-622. doi:10.1249/01.mss.0000210209.40694.09
14. 14. Roche C, Ragot C, Moalic JL, Simon F, Oliver M. Ibuprofen can induce syndrome of inappropriate diuresis in healthy young patients. Case Rep Med. 2013;2013:167267. doi:10.1155/2013/167267.
15. 15. Page AJ, Reid SA, Speedy DB, Mulligan GP, Thompson J. Exercise-associated hyponatremia, renal function, and nonsteroidal antiinflammatory drug use in an ultraendurance mountain run. Clin J Sport Med. 2007;17(1):43-48. doi:10.1097/JSM.0b013e31802b5be9