The Role of Platelet Levels in Emergency Department Assessment

Year 2024, Volume: 6 Issue: 2, 85 - 87, 05.09.2024

Bahaeddin Onur , Hakan Barış Demirbaş , Arif Gülmez

https://doi.org/10.55994/ejcc.1470621

Abstract

The assessment and management of platelet levels play a vital role in emergency medicine, particularly in the diagnosis and monitoring of various critical conditions such as trauma, sepsis, TTP, and HUS. Thrombocytopenia serves as a crucial indicator for identifying patients at risk of bleeding or coagulation disorders, guiding treatment decisions, and predicting clinical outcomes. By integrating platelet monitoring into the diagnostic and therapeutic algorithms of emergency care, healthcare providers can optimize patient management, improve outcomes, and enhance the overall quality of emergency medical services

Keywords

platelet; Emergency

References

• 1. Demirel ME, Kormaz UTK, Çetin Ö, Güldal H, Boğan M. The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm. Eurasian j Crit Care. 2023;5(2):56-62. doi:10.55994/ejcc.1323023.
• 2. Algın A, Özdemir S, Arslan E, Özkan A. Investigating the association between various platelet indices and different clinical sub-groups of severe malaria. Malawi Med J. 2023 Mar;35(1):3-8. doi: 10.4314/mmj.v35i1.2.
• 3. Algın A, Özdemir S. Evaluation of The Predictability of Platelet Mass Index for Short-Term Mortality in Patients with COVID 19: A Retrospective Cohort Study. J Contemp Med. September 2021;11(5):728-733. doi:10.16899/jcm.973825.
• 4. Blajchman MA, Slichter SJ, Heddle NM, Murphy MF. New strategies for the optimal use of platelet transfusions. Hematology Am Soc Hematol Educ Program. 2008:198-204. doi: 10.1182/asheducation-2008.1.198.
• 5. Zitek T, Weber L, Pinzon D, Warren N. Assessment and Management of Immune Thrombocytopenia (ITP) in the Emergency Department: Current Perspectives. Open Access Emerg Med. 2022 Jan 29;14:25-34. doi: 10.2147/OAEM.S331675.
• 6. Orak M, Karakoç Y, Ustundag M, Yildirim Y, Celen MK, Güloglu C. An investigation of the effects of the mean platelet volume, platelet distribution width, platelet/lymphocyte ratio, and platelet counts on mortality in patents with sepsis who applied to the emergency department. Niger J Clin Pract. 2018 May;21(5):667-671. doi: 10.4103/njcp.njcp_44_17.
• 7. Davenport RA, Brohi K. Coagulopathy in trauma patients: importance of thrombocyte function? Curr Opin Anaesthesiol. 2009 Apr;22(2):261-6. doi: 10.1097/ACO.0b013e328325a6d9.
• 8. Periayah MH, Halim AS, Mat Saad AZ. Mechanism Action of Platelets and Crucial Blood Coagulation Pathways in Hemostasis. Int J Hematol Oncol Stem Cell Res. 2017 Oct 1;11(4):319-327.
• 9. Kutcher ME, Redick BJ, McCreery RC, et al. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg. 2012 Jul;73(1):13-9. doi: 10.1097/TA.0b013e318256deab.
• 10. Hanes SD, Quarles DA, Boucher BA. Incidence and risk factors of thrombocytopenia in critically ill trauma patients. Ann Pharmacother. 1997 Mar;31(3):285-9. doi: 10.1177/106002809703100302.
• 11. Brown LM, Call MS, Margaret Knudson M, et al. A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma. 2011 Aug;71(2 Suppl 3):S337-42. doi: 10.1097/TA.0b013e318227f67c.
• 12. Bayraktar YŞ, Açıkgöz A, Eyiol H, et al. The Incidence of Thrombocytopenia and Its Association with Mortality in Patients with Sepsis Followed in Intensive Care Unit. Eurasian J Emerg Med. 2023;22(1): 24-7. DOI: 10.4274/eajem.galenos.2022.21549.
• 13. Vardon-Bounes F, Ruiz S, Gratacap MP, Garcia C, Payrastre B, Minville V. Platelets Are Critical Key Players in Sepsis. Int J Mol Sci. 2019 Jul 16;20(14):3494. doi: 10.3390/ijms20143494.
• 14. Shannon O. The role of platelets in sepsis. Res Pract Thromb Haemost. 2020 Dec 20;5(1):27-37. doi: 10.1002/rth2.12465.
• 15. Özdemir S, Algın A. The Role of Platelet Indices in Predicting Short-Term Mortality in Elderly Patients with Pulmonary Embolism. J Contemp Med. November 2021;11(6):833-837. doi:10.16899/jcm.988406.
• 16. Altunok İ, Özdemir S. Relationship Between Platelet Indices and Prolonged Hospitalization in Patients with Acute Pancreatitis: A Retrospective Observational Study. J Contemp Med. September 2022;12(5):743-748. doi:10.16899/jcm.1131462.
• 17. Özdemir S, Altunok I, Özkan A, et al. Relationship between platelet indices in acute cholecystitis: A case-control study. Rev Gastroenterol Mex (Engl Ed). 2023 Jul 5:S2255-534X(23)00070-1. doi: 10.1016/j.rgmxen.2023.04.012.
• 18. Santoshi RK, Patel R, Patel NS, Bansro V, Chhabra G. A Comprehensive Review of Thrombocytopenia With a Spotlight on Intensive Care Patients. Cureus. 2022 Aug 5;14(8):e27718. doi: 10.7759/cureus.27718.
• 19. He S, Fan C, Ma J, Tang C, Chen Y. Platelet Transfusion in Patients With Sepsis and Thrombocytopenia: A Propensity Score-Matched Analysis Using a Large ICU Database. Front Med (Lausanne). 2022 Feb 16;9:830177. doi: 10.3389/fmed.2022.830177.
• 20. Vardon-Bounes F, Ruiz S, Gratacap MP, Garcia C, Payrastre B, Minville V. Platelets Are Critical Key Players in Sepsis. Int J Mol Sci. 2019 Jul 16;20(14):3494. doi: 10.3390/ijms20143494.
• 21. Sukumar S, Lämmle B, Cataland SR. Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management. J Clin Med. 2021 Feb 2;10(3):536. doi: 10.3390/jcm10030536.
• 22. Öngören S, Salihoğlu A, Apaydın T, et al. Vincristine as an Adjunct to Therapeutic Plasma Exchange for Thrombotic Thrombocytopenic Purpura: A Single-Institution Experience. Balkan Med J. 2018 Nov 15;35(6):417-421. doi: 10.4274/balkanmedj.2017.1215.
• 23. Page EE, Kremer Hovinga JA, Terrell DR, Vesely SK, George JN. Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015. Blood Adv. 2017 Apr 6;1(10):590-600. doi: 10.1182/bloodadvances.2017005124.
• 24. Coppo P; French Reference Center for Thrombotic Microangiopathies. Management of thrombotic thrombocytopenic purpura. Transfus Clin Biol. 2017 Sep;24(3):148-153. doi: 10.1016/j.tracli.2017.05.015.
• 25. Elliott MA, Nichols WL. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Mayo Clin Proc. 2001 Nov;76(11):1154-62. doi: 10.4065/76.11.1154.
• 26. Shenkman B, Einav Y. Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: diagnosis and classification. Autoimmun Rev. 2014 Apr-May;13(4-5):584-6. doi: 10.1016/j.autrev.2014.01.004. Epub 2014 Jan 11.
• 27. Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001 Sep;60(3):831-46. doi: 10.1046/j.1523-1755.2001.060003831.x.