Evaluation of Patients with Corona Disease in the City Hospital

Year 2025, Volume: 7 Issue: 1, 13 - 16, 04.05.2025

Ömer Canpolat

Abstract

Background: Monitoring the values of eosinophils in particular among the blood cell count (CBC) parameters of patients who experienced COVID-19 and then worsened and become ex, highlights the importance of the mortality caused by the disease, and by early diagnosis, the necessary measures can be taken.
Methods: Our study is retrospective case control study. The clinical and laboratory data of 1039 patients who received a diagnosis of COVID-19 between March 11th and September 11th, 2020.
Results: The study was completed with a total of 1039 patients. Of the participants, 378 (36.4%) were female and 661 (63.6%) were female. The number of people who died from the disease was 172 (16.6%). Of the deceased patients, 63 were female. The mortality rate was higher in male patients, at 63.37%. Severe eosinopenia was found in 77.02% of the deceased patients. The number of eosinophil cells in surviving patients were very weak compared to the others, while the number of monocytes and lymphocytes in deceased patients were correlated.
Conclusions: Close monitoring of CBC parameters, particularly eosinophils, can be helpful in the early screening, treatment, and follow up of critically ill COVID-19 patients in terms of mortality

Keywords

COVID-19, eosinopenia, mortality, early diagnosis

References

• 1. Al-Tawfiq, J.A. & Memish Z.A. 2014. Middle East respiratory syndrome coronavirus: epidemiology and disease control measures. Infect. Drug Resist. 7: 281–287.
• 2. Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19)and other viral outbreaks. Clin Chem Lab Med.2020; 58: 1063-9.
• 3. Shimoni Z, Glick J, Froom P. Clinical utility of the full blood count in identifying patients with pandemic influenza A (H1N1). J Infect. 2013; 66:545-7.
• 4. Rothenberg ME, Hogan SP. The eosinophil. Annual review of immunology. 2006;24.
• 5. Flores-Torres AS, Salinas-Carmona MC, Salinas E and Rosas-Taraco AG: Eosinophils and respiratory viruses. Viral Immunol 2019;32(5):198-207,. PMID: 31140942. DOI: 10.1089/vim.2018.0150
• 6. Phipps S, Lam CE, Mahalingam S, Newhouse M, Ramirez R, Rosenberg HF, Foster PS and Matthaei KI: Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus. Blood 2007;110(5):1578-1586,. PMID: 17495130. DOI: 10.1182/ blood-2007-01-071340
• 7. Samarasinghe AE, Melo RC, Duan S, LeMessurier KS, Liedmann S, Surman SL, Lee JJ, Hurwitz JL, Thomas PG and McCullers JA: Eosinophils promote antiviral immunity in mice infected with influenza A virus. J Immunol 2017;198(8):3214-3226,. PMID: 28283567. DOI:0.4049/ jimmunol.1600787
• 8. XieG, DingF, HanL, YinD, Lu Hand Zhang M: The role of peripheral blood eosinophil counts in COVID-19 patients. Allergy, 2020. PMID: 32562554. DOI: 10.1111/all.14465
• 9. Azkur AK, Akdiş M, Azkur D, Sookolowska M, van de Veen W, Brüggen MC. Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19. Allergy. 2020. https://doi.org/10.1111/all. 14364. Online ahead of print
• 10. Percopo CM, Dyer KD, Ochkur SI Active mouse eosinophils protect against deadly respiratory virus infection. Blood. 2014; 123 :743–752.
• 11. Sabogal Pineros YS, Bal SM, van de Pol MA In mild asthma, Anti-IL-5 modifies rhinovirus-induced macrophage, B-cell and neutrophil responses (material). A placebocontrolled, double-blind study. J Respir Crit Care Med. 2019; 199 :508–517.
• 12. Ravanetti L., Dijkhuis A., Sabogal Pineros YS An innate early response underlies severe influenza-induced exacerbations of asthma in a new steroid-insensitive and anti-IL-5- responsive mouse model. Allergy. 2017; 72 :737–753.
• 13. Sabogal Pineros YS, Bal SM, Dijkhuis A. Eosinophils capture viruses with a defective capacity in asthma. Allergy. 2019; 74 :1898–1909.
• 14. Chen R, Sang L, Jiang M, Yang Z, Jia N, Fu W, Xie J, Guan W, Liang W, Ni Z, Hu Y, Liu L, Shan H, Lei C, Peng Y, Wei L, Liu Y , Hu Y , Peng P , Wang J , Liu J , Chen Z , Li G, Zheng Z , Qiu S , Luo J , Ye C , Zhu S , Zheng J , Zhang N , Li Y , he J , Li J , Li S and Zhong, N; Medical Treatment Expert Group for COVID-19: Longitudinal hematological and immunolog- Eurasian Journal of Critical Care. 2024;6(3): 13-17 Evaluation of Patients with Corona Disease in the City Hospital 17 ical variations associated with progression of COVID-19 patients in China. J Allergy Clin Immunol 146 ( 1 ): 89 - 100, 2020 . PMID: 32407836. DOI: 10.1016/j.jaci.2020.05.003
• 15. Lu G and Wang J: Dynamic changes in routine blood parameters of a severe COVID-19 case. Clin Chim Acta 508: 98 - 102, 2020. PMID: 32405079. DOI: 10.1016/j. cca.2020.04.034
• 16. Wang C, Deng R, Gou L,Fu Z, Zhang X, Shao F, Wang G, Fu W, Xiao J, ding X, Li T, Xiao X, and Li C: Severe to moderate COVID-19 using combined hematology parameters preliminary study to identify cases. Ann Transl Med 8 ( 9 ): 593 , 2020 . PMID: 32566620. DOI: 10.21037/atm-20-3391
• 17. Zhao L, Zhang YP, Yang X, and Liu X: Eosinopenia is associated with greater severity in patients with 2019 coronavirus disease. Allergy , 2020 . PMID: 32544252. DOI: 10.1111/all.14455
• 18. Zhang JJ, Dong X., Cao YY Clinical characteristics of 140 patients infected with SARSCoV-2 in Wuhan, China. Allergy. 2020; 75 :1730–1741.
• 19. Zhang Y., Xiao M., Zhang S. Coagulopathy and antiphospholipid antibodies in Covid-19 patients. NEngl J Med. 2020; 382 :e38.
• 20. Todd R., Donoff BR, Chiang T. Eosinophils as a cellular source of transforming growth factor alpha in the healing of skin wounds. I am J Pathol. 1991; 138 :1307-1313
• 21. Gieseck RL, 3rd, Wilson MS, Wynn TA Tissue repair and Type 2 immunity in fibrosis. Nat Rev Immunol. 2018; 18 :62-76.
• 22. Furuta GT, Atkins FD, Lee NA, Lee JJ The changing roles of eosinophils in health and disease. Ann Allergy Asthma Immunol. 2014; 113 :3–8.
• 23. Tanni F, Akker E, Zaman MM, Figueroa N, Tharian B and Hupart KH: Eosinopenia and COVID-19. J Am Osteopath Assoc, 2020. PMID: 32672799. DOI: 10.7556/jaoa.2020.091
• 24. Sun S, cai X, Wang H, O G, Lin Y, Lu B, Chen C, Pan Y, and Hu X: Peripheral blood system abnormalities in patients with COVID-19 in Wenzhou, China. Clin Chim Acta 507:174 - 180, 2020. PMID: 32339487. DOI: 10.1016/j. cca.2020.04.024
• 25. Du Y, Tu L, Zhu P, mu M, Wang R, Yang P, Wang X, hu C, ping R, hu P, Li T, Cao F, Chiang Ç, Hu Q ,Jin Y and Xu G : Wuhan Clinical features of 85 fatal COVID-19 cases from A retrospective observational study. Am J Respir Crit Care Med 201 ( 11 ): 1372 - 1379, 2020 . PMID: 32242738. DOI: 10.1164/rccm.202003-0543OC
• 26. Vasiliki E., Kopoulou G., Garmpıs N., Damaskos C., Valsami S., Dimitroulis D. et al. The Impact of Peripheral Eosinophil Counts and Eosinophil to Lymphocyte Ratio (ELR) in the Clinical Course of COVID-19 Patients: A Retrospective Study. In Vivo 2021;35:641-648 doi:10.21873/invivo.12303.
• 27. Lindsley AW, Schwartz JT, Rothenberg ME Eosinophil responses during COVID-19 infections and coronavirus vaccine. J Allergy Clinic Immunol. 2020; 146 :1–7.28. Qian GQ, Yang NB, Ding F. Epidemiological and clinical features of 91 hospitalized COVID-19 patients in Zhejiang, China: a retrospective, multicenter case series. QJM. 2020;113 :474–481.
• 29. Qin C., Zhou L., Hu Z. Dysregulation of immune response in patients with COVID-19 in Wuhan, China; Clinical Infectious Diseases Dis. 2020; 71 :762–768.