Oküler Doku Yapıştırıcıları

Year 2020, Volume: 3 Issue: 1, 19 - 36, 30.07.2020

Rumeysa Tutar Ayça Bal Öztürk

Abstract

Kornea yaraları cerrahi, enfeksiyonlardan ve travmatik yaralanmalardan kaynaklanmaktadır. Bu yaralar geleneksel olarak naylon sütürler kullanılarak onarılmaktadır. Kornea bölgesindeki yaralanmanın şekline ve derecesine bağlı olarak, korneanın y apısal bütün lüğünü geri kazanması için genellikle birden fazla sütüre ihtiyaç vardır. Doku yapıştırıcıları, oftalmik cerrahide sütürlerin yerine kullanılabilmektedir. Doku yapıştırıcıları, sütür yardımcı maddeleri ve yaralı dokuların sızdırmazlığı için alternatif olar ak geliştirilmiştir. Doku yapıştırıcıları, çapraz bağlandıktan sonra bir dokuya yapışabilen ve dünya çapında hemen hemen tüm ameliyatlarda önemli bir element olan polimer temelli hidrojel sistemleridir. Uygulama koşullarına göre dahili ve harici olar ak sın ıflandırılırlar. Harici doku yapıştırıcları genellikle yara kapatma ve epidermal aşılama gibi topikal uygulamalarda uygulanır . Dahili doku yapıştırıcları ise dokular, organlar ve kronik organ sızıntısı onarımı ve kanama komplikasyonlarının azaltılması gibi vücut sıvıları dahil olmak üzere iç ortama doğrudan temas ile intrakorporal koşullarda kullanılmaktadır. Bu derleme çalışmasında, o küler uygulamalara yönelik literatürde geliştirilen doku yapıştırıcları, ticari uygulamaları ve uygulama teknikleri üzerine odaklanılmıştır. Kornea insizyonları için kullanılan mevcut doku yapıştırıcıları tartışılmış, komplikasyonları, güvenlik profilleri ve etkinli kleri, sentez yöntemleri ve içerikleri birlikte değerlendirilmiştir. 

Keywords

Doku yapıştırıcısı, oküler uygulamalar, kornea, biyomalzeme

Ocular Tissue Adhesives

Abstract

Corneal wounds are caused by surgical infections and traumatic injuries. Traditionally, the nylon sutures are used to repair these corneal wounds. In order for the cornea to regain its structural integrity, more than one suture is usually required, depending on the shape and degree of the injury in the corneal wound. In ophthalmic surgery, tissue adhesives can be used instead of sutur es. Tissue adhesives have been developed as an alterna tive for suturing aids and for sealing injured tissues. Polymer based hydrogel systems, which can adhere to a tissue after crosslinking and are an important element in almost all surgeries worldwide, are applied as tissue adhesives. They are classified as internal and external according to the application conditions. External tissue adhesives are generally applied in topical applications such as wound closure and epidermal vaccination. On the other hand, internal tissue adhesives are used in intracorporeal conditions with direct contact to the internal environment including tissues, organs and body fluids such as chronic organ leak repair and reduction of bleeding complications. In this review study, tissue adhesives deve loped in the literature for ocular ap plications, commercial applications and application techniques of these adhesives are focused. Existing
tissue adhesives used for corneal incisions are discussed and complications, safety profiles and efficacy, synthesis methods and contents of these adhes ives are evaluated together.

Keywords

Tissue adhesives, ocular applications, cornea, biomaterial

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