Type 1 Diabetes Mellitus Associated with Autoimmune Thyroid Disease, Celiac Disease and Facial Asymmetry

Abstract

Patients with type 1 diabetes mellitus are at a great risk of developing other autoimmune diseases.Ten -year-old girl was brought to our clinic with complaints of polydipsia, polyuria and weight loss and was diagnosed as diabetic ketoacidosis due to autoimmune type 1 DM. On physical examination, on the left side of her face mild facial asymmetry was noticed. She had the asymmetry since the birth. Elevated thyroid antibodies associated with diffuse goiter and hypothyroidism led to the diagnosis of autoimmune thyroid disease, and elevated antiendomysial antibodies, anti-gliadin antibodies and abnormal intestinal biopsy findings led to the diagnosis of celiac disease . To our knowledge, this is the first report on a child with a combination type 1 diabetes mellitus, autoimmune thyroid disease, celiac disease and facial asymmetry. Further research is clearly required both to study associations between autoimmune diseases and facial asymmetry and the link between autoimmune diseases and facial asymmetry.

Keywords

• Type 1 diabetes mellitus, autoimmune thyroid disease, coeliac disease, facial asymmetry

Type 1 Diabetes Mellitus Associated with Autoimmune Thyroid Disease, Celiac Disease and Facial Asymmetry

Abstract

Tip 1 diabetes mellitus (DM) lu hastalar diğer otoimmün hastalıklara yatkınlık açısından büyük bir risk altındadır.10 yaşındaki kız hasta polidipsi, poliüri ve kilo kaybı şikayetleri ile kliniğimize başvurdu ve diabetik ketoasidoz tanısı aldı. Hastaya insülin tedavisi başlandı. Diffüz guatr , hipotiroidi ve artmış tiroid antikorları ile otoimmün tiroid hastalığı (AITD) tanısını; yükselmiş antiendomisyum antikoru (EMA), anti-gliadin antikor (AGA) ve anormal barsak biyopsi bulguları ile çölyak hastalığı tanısını aldı.Hastaya L-tiroksin tedavisi ve glutensiz diyet başlandı. Hastanın yüzünün sol tarafında hafif bir asimetri vardı. Bildiğimiz kadarıyla, bu yazıda ilk defa tip 1 DM, AITD, CD ve sol yüz asimetrisinin birlikte olduğu bir hasta sunulmaktadır. Otoimmün hastalıklar ve fasiyal asimetri arasındaki ilişkiyi incelemek için ileri araştırmalar gereklidir

Keywords

• Tip 1 diabetes mellitus, otoimmün troid hastalığı, çölyak hastalığı, fasiyal asimetri

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