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Laryngeal Carcinoma with Chronic Lymphocyter Leukemia

Year 2014, , - , 21.03.2016
https://doi.org/10.15197/sabad.1.11.25

Abstract

In this study, we report an extraordinary case in which a patient was diagnosed with laryngeal squamous cell carcinoma and simultaneous chronic lymphocytic leukemia. A 53-year-old male patient presented with hoarseness and a neck mass. Laryngeal examination revealed a lesion that had infiltrated the right band, cord, and ventricle, and the left cord and band. There were multiple bilateral lymphadenopathies in the supraclavicular, inguinal, and axillary regions, the largest of which was 4x4 cm. Following hematology consultation, a direct laryngoscopy and biopsy were performed. An excisional biopsy was taken from the neck mass. The postoperative histopathology reported an invasive squamous cell carcinoma in the larynx and a small B cell lymphoid leukemia in the neck. Following consultation with our oncology department, curative radiotherapy was applied to the neck region. Following this therapy, the mass was no longer detectable upon palpation, although no curative treatment was applied for leukemia. It is important to be aware that lymphadenopathy may be secondary to head or neck cancer or to a hematological malignancy. Thus, preoperative evaluation should be carefully performed, and hematological malignancy should be considered as a differential diagnosis when histopathologically evaluating neck dissection material.

References

  • Kalil N, Cheson BD. Chronic lymphocytic leukemia. The Oncologist 1999;4:352-69
  • Bannerdi R, Byrd JC. Update on biology of chronic lym- phocytic leukemia. Curr Opin Oncol 2000;12:222-9
  • Lin TS, Byrd JJ. Chronic Lymphocytic Leukemias And Related Leukemias. In Chang AF, Ganz PA, Kinsella TJ et al., ed. Oncology. New York: Springer, 2006: 1201-20
  • Greene MH, Hoover RN, Fraumani JF. Subsequent cancers in patients with chronic lymphocytic leukemia–a possible immunologic mechanism. J Natl Cancer Inst 978;61:337-40
  • Travis LB, Curtis RE, Hankey BF, Fraumani JF. Second Cancer in Patients With Chronic Lymphocytic Leukemia. J Cancer Inst 1992;84: 1422-7
  • Hisada M, Biggar RJ, Greene MH, Fraumani JF, Travis LB. Solid Tumors After Chronic Lymphocytic Leukemia. Blood 2001;98:1979-81
  • Uhlrich YM, Bordesseula D, Olivier J, et al. Association Leucemialymphoide Chronique-epidermoide de Plancher Buccal. Rev Stomatol Chir Maxillofac 1983; 84:298-301
  • Chow WH, Swanson CA, Lissowska J, et al. Risk of Stomach Cancer in Relation to Consumption Of Cigarettes, Alcohol, Tea and Coffee in Warsaw, Poland. Inst J Cancer 1998;81:871-6.
  • Baron JA, Rohan TE. Tobacco in. Schottenfeld D, Fraumani JF. Cancer Epidemiology and Prevention, 2nd ed. New York: Oxford University Press, 1996:269-89
  • Van Leeuveen FE, Klokman WJ, Stovall M, et al. Role Of Radiotherapy in Lung Cancer After Hodgkin’s Disease. J Natl Cancer Inst 1995;8:1530-7
  • Nigri PT, Kashgiwala CK. Unusual Presentation Of Head And Neck Cancer. Laryngoscope 1982;92:1245-6
  • Diguid JKM, Mackie MJ, McVerry BA. Skin Infiltration in Association With Chronic Myelocytic Leukemia. British J Heamatol 1983;53:257-64
  • Brito-Bappapule F, Lord JAD, Barbatis C, Whitmore ND. Laryngeal Infiltration in Chronic Myelomonocytic Leukemia. Clin Lab Heamatol 1989;11:403-6
  • Cheson BD. Chronic lymphoid leukemias. In Abeloff MD, Arbeloff JO, Lichter AS et al., ed. Clinical Oncology, First Edition, New York: Churchill Livingstone Inc. 1995; 1999- 2022
  • Robertson LE, Pugh W, O’Brien S, et al. Richter’s Syndrome: A Report on 39 Patients. J Clinic Oncol 1993;11:1985-9
  • Cheson BD. Therapy For Previously Untreated Chronic Lymphocytic Leukemia: A Reevaluation. Semin Hematol 1998;35 (suppl 3):14-21
  • Zinzani PL. Interferon in CLL. Hematol Cell Ther 1997;39:S61
  • Schindler A, Cuccarini V, Bottero A et al. Long Term Vocal Functional Results After Glottectomy: A Multidimensional Analysis. Eur Arch Otorhinolaryngol 2007;264:1039-44
  • Laudadio P, Pressuti Livio, Dall’olio D, et al. Supracricoid Laryngectomies: Long Term Oncological and Functional Results. Acta Otolaryngol 2006;126:640-9
  • Ferlito A, Recher G, Visona A. Laryngeal Cancer Metastatic to Lymph Nodes with Lymphocytic Leukemia. J Laryngol Otol 1986:100;233-7

Laryngeal Carcinoma with Chronic Lymphocyter Leukemia

Year 2014, , - , 21.03.2016
https://doi.org/10.15197/sabad.1.11.25

Abstract

Bu çalışmada larengeal yassı epitel hücreli karsinom ile kronik lenfositer lösemi tanılarının eş zamanlı olarak konulduğu sıradışı bir vakayı sunuyoruz. 53 yaşında erkek hasta ses kısıklığı ve boyunda kitle nedeni ile başvuruda bulundu. Larengeal muayenede sağ kord, sağ band ile ventrikül ve sol kord ile bandı tutan infiltratif lezyon saptandı. En büyüğü 4x4 cm boyutlarında ve bilateral supraklavikuler, inguinal ve aksiller çok sayıda lenf nodu mevcutu. Hematoloji konsültasyonunu takiben direk larengoskopi eşliğinde biyopsi alındı. boyundan da eksizyonel biyopsi alındı. Histopatolojik inceleme sonucu larenkste İnvazif yassı epitel hücreli karsinom ve boyunda B hücreli lenfoid lösemi tanıları konuldu. Onkoloji konsültasyonu sonucu hastaya küratif radyoterapi uygulanmasına karar verildi. Bu tedavinin sonunda kronik lenfositer lösemiye yönelik küratif tedavi uygulanmamasına rağmen boyundaki kitleler geriledi. Boyun bölgesinde saptanan lenfadenopatilerin baş boyun bölgesi malinitelerinin yanısıra hematolojik malinitelere de bağlı olabileceği unutulmamalıdır. Preoperatif boyun değerlendirmelerinde ve boyun disseksiyon materyallerinin incelenmesinde hematolojik maliniteler ayırıcı tanıda yer almalıdır

References

  • Kalil N, Cheson BD. Chronic lymphocytic leukemia. The Oncologist 1999;4:352-69
  • Bannerdi R, Byrd JC. Update on biology of chronic lym- phocytic leukemia. Curr Opin Oncol 2000;12:222-9
  • Lin TS, Byrd JJ. Chronic Lymphocytic Leukemias And Related Leukemias. In Chang AF, Ganz PA, Kinsella TJ et al., ed. Oncology. New York: Springer, 2006: 1201-20
  • Greene MH, Hoover RN, Fraumani JF. Subsequent cancers in patients with chronic lymphocytic leukemia–a possible immunologic mechanism. J Natl Cancer Inst 978;61:337-40
  • Travis LB, Curtis RE, Hankey BF, Fraumani JF. Second Cancer in Patients With Chronic Lymphocytic Leukemia. J Cancer Inst 1992;84: 1422-7
  • Hisada M, Biggar RJ, Greene MH, Fraumani JF, Travis LB. Solid Tumors After Chronic Lymphocytic Leukemia. Blood 2001;98:1979-81
  • Uhlrich YM, Bordesseula D, Olivier J, et al. Association Leucemialymphoide Chronique-epidermoide de Plancher Buccal. Rev Stomatol Chir Maxillofac 1983; 84:298-301
  • Chow WH, Swanson CA, Lissowska J, et al. Risk of Stomach Cancer in Relation to Consumption Of Cigarettes, Alcohol, Tea and Coffee in Warsaw, Poland. Inst J Cancer 1998;81:871-6.
  • Baron JA, Rohan TE. Tobacco in. Schottenfeld D, Fraumani JF. Cancer Epidemiology and Prevention, 2nd ed. New York: Oxford University Press, 1996:269-89
  • Van Leeuveen FE, Klokman WJ, Stovall M, et al. Role Of Radiotherapy in Lung Cancer After Hodgkin’s Disease. J Natl Cancer Inst 1995;8:1530-7
  • Nigri PT, Kashgiwala CK. Unusual Presentation Of Head And Neck Cancer. Laryngoscope 1982;92:1245-6
  • Diguid JKM, Mackie MJ, McVerry BA. Skin Infiltration in Association With Chronic Myelocytic Leukemia. British J Heamatol 1983;53:257-64
  • Brito-Bappapule F, Lord JAD, Barbatis C, Whitmore ND. Laryngeal Infiltration in Chronic Myelomonocytic Leukemia. Clin Lab Heamatol 1989;11:403-6
  • Cheson BD. Chronic lymphoid leukemias. In Abeloff MD, Arbeloff JO, Lichter AS et al., ed. Clinical Oncology, First Edition, New York: Churchill Livingstone Inc. 1995; 1999- 2022
  • Robertson LE, Pugh W, O’Brien S, et al. Richter’s Syndrome: A Report on 39 Patients. J Clinic Oncol 1993;11:1985-9
  • Cheson BD. Therapy For Previously Untreated Chronic Lymphocytic Leukemia: A Reevaluation. Semin Hematol 1998;35 (suppl 3):14-21
  • Zinzani PL. Interferon in CLL. Hematol Cell Ther 1997;39:S61
  • Schindler A, Cuccarini V, Bottero A et al. Long Term Vocal Functional Results After Glottectomy: A Multidimensional Analysis. Eur Arch Otorhinolaryngol 2007;264:1039-44
  • Laudadio P, Pressuti Livio, Dall’olio D, et al. Supracricoid Laryngectomies: Long Term Oncological and Functional Results. Acta Otolaryngol 2006;126:640-9
  • Ferlito A, Recher G, Visona A. Laryngeal Cancer Metastatic to Lymph Nodes with Lymphocytic Leukemia. J Laryngol Otol 1986:100;233-7
There are 20 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Güven Yıldırım This is me

Güler Berkiten This is me

Ziya Saltürk This is me

Demet Aydın This is me

Suzan Deniz Önol This is me

Ferhan Adatepe This is me

Filiz Filiz This is me

Publication Date March 21, 2016
Published in Issue Year 2014

Cite

APA Yıldırım, G., Berkiten, G., Saltürk, Z., Aydın, D., et al. (2016). Laryngeal Carcinoma with Chronic Lymphocyter Leukemia. European Journal of General Medicine, 11(12). https://doi.org/10.15197/sabad.1.11.25
AMA Yıldırım G, Berkiten G, Saltürk Z, Aydın D, Önol SD, Adatepe F, Filiz F. Laryngeal Carcinoma with Chronic Lymphocyter Leukemia. European Journal of General Medicine. March 2016;11(12). doi:10.15197/sabad.1.11.25
Chicago Yıldırım, Güven, Güler Berkiten, Ziya Saltürk, Demet Aydın, Suzan Deniz Önol, Ferhan Adatepe, and Filiz Filiz. “Laryngeal Carcinoma With Chronic Lymphocyter Leukemia”. European Journal of General Medicine 11, no. 12 (March 2016). https://doi.org/10.15197/sabad.1.11.25.
EndNote Yıldırım G, Berkiten G, Saltürk Z, Aydın D, Önol SD, Adatepe F, Filiz F (March 1, 2016) Laryngeal Carcinoma with Chronic Lymphocyter Leukemia. European Journal of General Medicine 11 12
IEEE G. Yıldırım, G. Berkiten, Z. Saltürk, D. Aydın, S. . D. Önol, F. Adatepe, and F. Filiz, “Laryngeal Carcinoma with Chronic Lymphocyter Leukemia”, European Journal of General Medicine, vol. 11, no. 12, 2016, doi: 10.15197/sabad.1.11.25.
ISNAD Yıldırım, Güven et al. “Laryngeal Carcinoma With Chronic Lymphocyter Leukemia”. European Journal of General Medicine 11/12 (March 2016). https://doi.org/10.15197/sabad.1.11.25.
JAMA Yıldırım G, Berkiten G, Saltürk Z, Aydın D, Önol SD, Adatepe F, Filiz F. Laryngeal Carcinoma with Chronic Lymphocyter Leukemia. European Journal of General Medicine. 2016;11. doi:10.15197/sabad.1.11.25.
MLA Yıldırım, Güven et al. “Laryngeal Carcinoma With Chronic Lymphocyter Leukemia”. European Journal of General Medicine, vol. 11, no. 12, 2016, doi:10.15197/sabad.1.11.25.
Vancouver Yıldırım G, Berkiten G, Saltürk Z, Aydın D, Önol SD, Adatepe F, Filiz F. Laryngeal Carcinoma with Chronic Lymphocyter Leukemia. European Journal of General Medicine. 2016;11(12).