Laryngeal Carcinoma with Chronic Lymphocyter Leukemia

Abstract

In this study, we report an extraordinary case in which a patient was diagnosed with laryngeal squamous cell carcinoma and simultaneous chronic lymphocytic leukemia. A 53-year-old male patient presented with hoarseness and a neck mass. Laryngeal examination revealed a lesion that had infiltrated the right band, cord, and ventricle, and the left cord and band. There were multiple bilateral lymphadenopathies in the supraclavicular, inguinal, and axillary regions, the largest of which was 4x4 cm. Following hematology consultation, a direct laryngoscopy and biopsy were performed. An excisional biopsy was taken from the neck mass. The postoperative histopathology reported an invasive squamous cell carcinoma in the larynx and a small B cell lymphoid leukemia in the neck. Following consultation with our oncology department, curative radiotherapy was applied to the neck region. Following this therapy, the mass was no longer detectable upon palpation, although no curative treatment was applied for leukemia. It is important to be aware that lymphadenopathy may be secondary to head or neck cancer or to a hematological malignancy. Thus, preoperative evaluation should be carefully performed, and hematological malignancy should be considered as a differential diagnosis when histopathologically evaluating neck dissection material.

Keywords

• Laryngeal carcinoma, chronic lymphocytic leukemia, neck, lymphadenopathy

Laryngeal Carcinoma with Chronic Lymphocyter Leukemia

Öz

Bu çalışmada larengeal yassı epitel hücreli karsinom ile kronik lenfositer lösemi tanılarının eş zamanlı olarak konulduğu sıradışı bir vakayı sunuyoruz. 53 yaşında erkek hasta ses kısıklığı ve boyunda kitle nedeni ile başvuruda bulundu. Larengeal muayenede sağ kord, sağ band ile ventrikül ve sol kord ile bandı tutan infiltratif lezyon saptandı. En büyüğü 4x4 cm boyutlarında ve bilateral supraklavikuler, inguinal ve aksiller çok sayıda lenf nodu mevcutu. Hematoloji konsültasyonunu takiben direk larengoskopi eşliğinde biyopsi alındı. boyundan da eksizyonel biyopsi alındı. Histopatolojik inceleme sonucu larenkste İnvazif yassı epitel hücreli karsinom ve boyunda B hücreli lenfoid lösemi tanıları konuldu. Onkoloji konsültasyonu sonucu hastaya küratif radyoterapi uygulanmasına karar verildi. Bu tedavinin sonunda kronik lenfositer lösemiye yönelik küratif tedavi uygulanmamasına rağmen boyundaki kitleler geriledi. Boyun bölgesinde saptanan lenfadenopatilerin baş boyun bölgesi malinitelerinin yanısıra hematolojik malinitelere de bağlı olabileceği unutulmamalıdır. Preoperatif boyun değerlendirmelerinde ve boyun disseksiyon materyallerinin incelenmesinde hematolojik maliniteler ayırıcı tanıda yer almalıdır

Anahtar Kelimeler

• Laringeal karsinoma, kronik lenfositer lösemi, boyun, lenfadenopati

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