Angiomyofibroblastoma of The Vulva

Year 2014, , - , 21.03.2016

Emel Kurtoglu Rabia Kaya Nevin Topak

https://doi.org/10.15197/sabad.1.11.29

Abstract

Anjiyomiyofibroblastom, genellikle orta yaş kadınlarda,pelviperianal bölgede ender olarak görülen,çok iyi sınırlı selim bir tümördür.Tümör hücreleri damarlar etrafında iğsi daireler şeklinde yerleşmişlerdir.Hemen her zaman desmin ve vimentin,sürekli olarak östrojen ve progesteron reseptörleri için olmakla birlikte bazen de CD 34 için immünreaktiftirler.Cerrahi tedavide tam ekzisyon gereklidir.Yetersiz tedaviden kaçınmak için,tümörü agresif anjiyomiksomdan ayırt etmek oldukça önemlidir.Burada,46 yaşında postmenopozal dönemdeki bir kadın hastada,farklı histopatolojik bulguları olan bir vulvar anjiyomiyofibroblastom olgusu sunulmaktadır.Tümör hücreleri fibrodipoz doku içermekte ve desmin ve aktin için negatif immünreaktivite göstermektedir

Keywords

Anjiyomiyofibroblastom, vulva, postmenopoz

Angiomyofibroblastoma of The Vulva

Abstract

Angiomyofibroblastoma is a rare,benign,well-circumscribed neoplasm predominantly occurring in the pelviperineal region of middle-aged women. The tumour cells are round-to-spindle shaped concentrated around vessels. They almost have immunoreactivity for desmin and vimentin,consistently positive for estrogen and progesteron receptors,occasionally positive for CD 34. The complete surgical excision of the tumour is necessary. It is important to distinguish this tumour from especially aggressive angiomyxoma to avoid inadequate treatment. Here,we report a case of vulvar angiomyofibroblastoma in a 46-year old postmenopausal woman whose findings were differentiating from others. Histologically,the tumour involved fibroadipose tissue and immunoreactivity for desmin and actin was negative.

Keywords

Angiomyofibroblastoma, vulva, postmenopause

References

• Fletcher CDM, Angiomyofibroblastoma. In Fletcher CDM, Unni KK, Mertens F, eds.WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Chapter 2: Fibroblastic/myofibroblastic tumours. Lyon: IARC Press 2002: 71-2
• Fletcher CD, Tsang WY, Fisher C, Lee KC, Chan JK. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggresive angiomyxoma. Am J Surg Pathol 1992;16:373-82
• Fukunaga M, Nomura K, Matsumoto K, Doi K, Endo Vulvar Y, Clinicopathologic analysis of six cases. Am J Clin Pathol 1997;107:45-51
• angiomyofibroblastoma.
• Laskin WB, Fetsch JF, Tavassoli FA. Angiomyofibroblastoma of the female genital tract: analysis of 17 cases including a lipomatous variant. Hum Pathol 1997;28:1046-55
• Nielsen GP, Rosenberg AE, Young RH, Dickersin GR, Clement PB, Scully RE. Angiomyofibroblastoma of the vulva and vagina. Mod Pathol 1996;9:284-91
• Ockner DM, Sayadi H, Swanson PE, Ritter JH, Wick MR. Genital angiomyofibroblastoma. Comparison with aggres- sive angiomyxoma and other myxoid neoplasms of skin and soft tissue. Am J Clin Pathol 1997;107:36-44
• Canales BK, Weiland D, Hoffman N, et al. Angiomyofibroblastoma-like tumors (cellular angiofibro- ma). Int J Urol 2006;13:177-9
• Perko Z, Durdov MG, Druzijanic N, Kraljevic D, Juricic J. Giant perianal angiomyofibroblastoma-a case report. Coll Antropol 2006;30:243-6
• Barat S, Tirgar-Tabari S, Shafaee S. Angiomyofibroblastoma of the vulva. Arch Iran Med, 2008;11:224-6
• Quintero C, Sasken H, Houck KL, Hernandez E. Angiomyofibroblastoma of the retroperitoneum:a case report. J Report Med 2007;52:741-4
• Micheletti AM, Silva AC, Nascimento AG, Da Silva CS, Murta EF, Adad SJ. Cellular angiofibroma of the vulva:case report with clinicopathological and immunohistochemis- try study. Sao Paulo Med J 2005;123:250-2
• Ito M, Yamaoka H, Sano K, Hotchi M. Angiomyofibroblastoma of the male inguinal region. Arch Pathol Lab Med 2000;124:1679-81
• Cetinkaya K, Al RA, Gursan N. Angiomyofibroblastoma of the vulva during pregnancy. J Obstet Gyneacol Res 2011;37: 1162-5
• Kobayashi T, Suzuki K, Arai T, Sugimura H. Angiomyofibroblastoma arising from the fallopian tube. Obstet Gynecol 1999;94:833-4
• Nagai K, Aadachi K, Saito H. Huge pedunculated angiomyo- fibroblastoma of the vulva. Int J Clin Oncol 2010;15:201-5
• Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis- Kindblom JM. Aggressive angiomyxoma: a clinicopatho- logic study of 29 female patients. Cancer 1996;78:79-90
• Granter SR, Nucci MR, Fletcher CD. Aggressive angiomyx- oma: reappraisal of its relationship to angiomyofibroblas- toma in a series of 16 cases. Histopathology 1997;30:3-10.