Antibiotic Susceptibility of Group A

Abstract

Tonsillopharyngitis is a common infectious disease in the pediatric age group. Group A Beta Hemolytic Streptococcus (GAS) is a main infectious agent of pharyngitis. Optimal therapeutic approach in these patients has been a matter of debate to avoid the complications of infection. The aim of this study was to investigate of antibiotic susceptibility for group A β-hemolytic Streptococci which isolated from tonsillar swab samples of 5-15 years old children. 2599 outpatient children who are 5-15 years old and have general infection symptoms like high fever, weakness, chills-shivering and observed hyperemia at tonsils and pharynx were included in the study. Tonsillopharyngeal culture and antimicrobial susceptibility tests were performed. 319 (12,3%) GAS isolates was obtained from tonsillopharyngeal cultures of the 2599 patients. Susceptibility to penicillin, vancomycin, linezolid, cefotaxime, erythromycin, chloramphenicol, and clindamycin were 100%, 100%, 100%, 100%, 97,2%, 98,3%, and 94,7% respectively.Resistance to penicillin was not yet observed, penicillin may safely be chosen to treatment of these infections for non-allergic patients to penicillin. It is considered that culture and antibiotic susceptibility testing may be more useful to for the diagnosis and treatment of these patients.

Keywords

• Streptococcus pyogenes, antibiotic, susceptibility, children

Antibiotic Susceptibility of Group A

Öz

Tonsillofarenjit pediatrik yaş grubunda sık görülen bir enfeksiyon hastalığıdır. A Grubu Beta Hemolitik Streptokokar (GAS) en sık farenjit etkenlerindendir. Bu enfeksiyonun komplikasyonlarını önlemek bakımından en uygun tedavi yaklaşımı tartışma konusu olmuştur. Bu çalışmanın amacı, 5-15 yaş grubu çocukların tonsiller sürüntü örneklerinden izole edilen A Grubu β-hemolitik Streptokokların antibiyotik duyarlılık oranlarının araştırılmasıdır. 5-15 yaş grubunda, yüksek ateş, halsizlik, üşüme-titreme gibi genel enfeksiyon belirtileri ile polikliniğe başvuran, bademcik ve farinkste hiperemi gözlemlenen 2599 çocuk hasta çalışmaya dahil edildi. Boğaz kültürü ve antibiyotik duyarlılık testleri yapıldı. 2599 hastanın tonsillo-faringial kültürlerinden 319’unda (12,3%) GAS izole edilmiştir. Penisilin, vankomisin, linezolid, sefotaksim, eritromisin, kloramfenikol ve klindamisin duyarlılık oranları sırasıyla % 100, % 100,% 100,% 100,% 97,2, %98,3 ve % 94,7 olarak bulunmuştur. Bu enfeksiyonların tedavisinde, penisilin dienci bulunmadığından, penisilin alerjisi olmayan hastalar için güvenle seçilebilir. Bu hastaların tanı ve tedavisinde, kültür ve antibiyotik duyarlılık testlerinin yapılmasının daha yararlı olabileceği düşünülmektedir. Anahtar kelimeler: Streptococcus pyogenes, antibiyotik, duyarlılık, çocuklar

Anahtar Kelimeler

• Streptococcus pyogenes, antibiyotik, duyarlılık, çocuklar

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