Heart Failure: Discrepancy Between NYHA Functional Classification, Serum NT-pro Brain Natriuretic Peptide and Ejection Fraction

Abstract

This study aimed to look for the discrepancy between the laboratory investigation (determination of serum NT-proBNP), electrophysiological assessment (echocardiogram and Doppler study) and clinical assessment of known cases of congestive heart failure.This study conducted in the college teaching hospital from January to October 2011. This study is a cross-sectional in a cohort of patients with heart failure. Known cases of congestive heart failure and healthy subjects served as control group were enrolled in this study. Patients were assessed clinically according to the New York Heart Association (NYHA) functional classification, echocardiography by ejection fraction and laboratory by determination of NT-proBNP).Student&#39;s &quot;t&quot; test (one paired, two tailed) and simple correlation test were used in data analysis. The results of 169 patients enrolled in this study showed that serum levels of NT-proBNP did not match the NYHA functional classification of heart failure. Serum NT-proBNP was significantly inversed-correlated (r = -0.339, p < 0.001) with the ejection fraction and inconsistently related to the E/A ratio assessed by Doppler study. It concludes that serum NT-proBNP level is well correlated with ejection fraction and not well matched the functional disabilities of longstanding heart failure.

Keywords

• NT-proBNP, Heart failure, ejection fraction

Heart Failure: Discrepancy Between NYHA Functional Classification, Serum NT-pro Brain Natriuretic Peptide and Ejection Fraction

Öz

Bu çalışma konjestif kalp yetmezliği bilinen olgularda laboratuar inceleme (serum NT-pro BNP değerlendirmesi), elektrofizyolojik değerlendirme (ekokardiyografi ve Doppler çalışması) ve klinik değerlendirme arasındaki tutarsızlığı araştırmayı amaçlamıştır. Bu çalışma Ocak-Ekim 2011 tarihleri arasında üniversite araştırma hastanesinde yapılmıştır. Bu, kalp yetmezliği olan hastalardan oluşan bir kohortta kesitsel bir çalışmadır. Konjestif kalp yetmezliği bilinen vakalar ve sağlıklı bireyler bu çalışmaya kontrol grubu olarak katılmışlardır. Hastalar, klinik olarak New York Kalp birliğinin (NYHA) fonksiyonel sınıflaması, ekokardiyografik olarak ejeksiyon fraksiyonu ve laboratuar inceleme olarak NT-pro BNP değerine göre değerlendirilmişlerdir. Veri analizi Student’s t testi (bir çift, iki uçlu) ve basit korelasyon testi kullanılarak yapılmıştır. Çalışmaya alınan 169 hastanın sonuçları göstermiştir ki serum NT- pro BNP düzeyleri kalp yetmezliğinin NYHA fonksiyonel sınıflaması ile uyumlu değildir. Serum NT-pro BNP düzeyleri anlamlı şekilde ejeksiyon fraksiyonu ile ters orantılıdır (r = -0.339, p < 0.001) ve Doppler çalışması ile değerlendirilen E/A oranı ile tutarsız şekilde ilişkilidir. Sonuç olarak serum NT-pro BNP düzeyleri ejeksiyon fraksiyonu ile iyi koreledir ve uzun süren kalp yetmezliğinin fonksiyonel kısıtlamaları ile iyi uyum göstermemektedir

Anahtar Kelimeler

• NT-pro BNP, kalp yetmezliği, ejeksiyon fraksiyonu

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