The Effect of Sevoflurane and Desflurane on the Early Postoperative Cognitive Functions in Geriatric Patients

Abstract

Our aim was to compare the effects of desflurane and sevoflurane on cognitive functions of geriatric patients that were planned for elective surgery under general anestesia. After national ethical committee approval, 40 patients (aged 65-75 yr) were enrolled. Patients were allocated to either the desflurane (n=20) or the sevoflurane (n=20) group. In all patients anaesthesia will be induced with propofol and remifentanyl, and maintained with the anaesthetics desflurane, or sevoflurane, and remifentanyl. Emergence times from anaesthesia and Aldrete scores were recorded. Cognitive function will be evaluated with two cognitive test; Blessed Short Orientation Memory Concentration Test (BOMC) and standardized mini mental test (SMMT) preoperatively and postoperatively at 60, and 180 minute after extubation. The mean extubation time, eye opening time and Aldrete scores were similar in the desflurane and sevoflurane groups (p>0,05). There were no significant differences between the desflurane and the sevoflurane groups when the BOMC and MMST scores were compared preoperatively, and postoperatively at 60, and 180 min (p>0,05).The result of this study indicate that there is no difference between effects of desflurane and sevoflurane anesthesia on postoperatif cognitive functions in the elderly.

Keywords

• Aged, cognitive disorders, diagnosis, desflurane, sevoflurane

The Effect of Sevoflurane and Desflurane on the Early Postoperative Cognitive Functions in Geriatric Patients

Öz

Genel anestezi altında, elektif cerrahi girişim geçirecek geriatrik olgularda desfluran ve sevofluranın erken postoperatif kognitif fonksiyonlar üzerine etkilerini karşılaştırmayı amaçladık. Ulusal etik kurul izni alındıktan sonra, yaşları 65-75 arasında olan 40 hasta çalışmaya dahil edildi. Hastalar desfluran (n=20) ve sevofluran (n=20) olarak iki gruba ayrıldı. Tüm hastaların anestezi indüksiyonunda propofol ve remifantil kullanılırken, anestezi idamesinde remifentanil ile birlikte desfluran veya sevofluran kullanıldı. Anesteziden uyanma zamanları ve Aldrete derlenme skorları kaydedildi. Hastaların kognitif fonksiyonları iki kognitif test; Kısa Blessed Oryantasyon Bellek Konsantrasyon Testi (BOMC) ve Standardize Mini Mental Test (SMMT) ile preoperatif ve postoperatif ekstübasyon sonrası 60. ve 180. dakikalarda değerlendirildi. Ortalama ekstübasyon süreleri, göz açma süreleri ve Aldrete skorları desfluran ve sevofluran grubunda benzerdi (p>0,05). Preoperatif ve postoperatif 60. ile 180. dakikalarda BOMC ve MMST skorları karşılaştırıldığında sevofluran ve desfluran grupları arasında anlamlı fark yoktu (p>0,05). Geriatrik hastalarda desfluran ve sevofluran anestezisinin erken postoperatif kognitif fonksiyonlar üzerine benzer etkilere sahip olduğu sonucuna varıldı

Anahtar Kelimeler

• Yaşlılık, kognitif bozukluklar, tanı, desflurayin, sevoflurayin

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