DEVELOPMENT OF PURULENT MENINGITIS IN A CHILD WITH NEPHROTIC SYNDROME WHILE RECEIVING CEPHTRIAXONE PLUS AMIKACIN

Abstract

-

Keywords

• -

DEVELOPMENT OF PURULENT MENINGITIS IN A CHILD WITH NEPHROTIC SYNDROME WHILE RECEIVING CEPHTRIAXONE PLUS AMIKACIN

Abstract

Malatya State Hospital1, Malatya, Dicle University Medical School, Department of Pediatrics2, Diyarbakır, Turkey A child with nephrotic syndrome (NS) presented with peritonitis caused by E. coli susceptible to both cephtriaxone and amikacin. Purulent meningitis developed in accompanying with clinical and laboratory findings at the 5th day of treatment. Pneumococcal antigen was detected in cerebro-spinal fluid and meningitis was treated with meropenem. Development of pneumococal meningitis while receiving broad-spectrum antibiotics for peritonitis is an unusual situation

Keywords

• Children, nephrotic syndrome, meningitis, peritonitis, meropenem

References

1. Tain YL, Lin G, Cher TW. Microbiological spectrum of septicemia and peritonitis in nephrotic children. Pediatr Nephrol 1999; 13: 835-7
2. McIntyre P, Craig JC. Prevention of serious bacterial infection in children with nephrotic syndrome. J Paediatr Child Health 1998;34:314-7
3. Gulati S, Kher V, Gupta A, Arora P, Rai PK, Sharma RK. Spectrum of infections in Indian children with nephrotic syndrome. Pediatr Nephrol 1995;9:431-4
4. Niaudet P. Steroid-resistant idiopathic nephrotic In: Barratt TM, Avner ED, Harmon WE, eds. Pediatric Nephrology, 4th edition, Williams&Wilkins, 1999:750-1 Lippincott
5. Overturf GD. American Academy of Pediatrics. Committee on Infectious Diseases. Technical report: prevention of pneumococcal infections, including the use of pneumococcal conjugate and polysaccharide vaccines and antibiotic prophylaxis. Pediatrics 2000;106:367-76
6. John CC, Aouad G, Berman B, Schreiber JR. Successful meropenem treatment of multiply resistant pneumococcal meningitis. Pediatr Infect Dis J 1997;6: 1009-11
7. Bradley JS; Scheld WM. The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: current antibiotic therapy in the 1990s. Clin Infect Dis 1997; 24 (suppl 2):S213-21 141