Abstract
Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis in children. Mean platelet volume (MPV) is an indicator of platelet size and has been investigated as an inflammation marker in several diseases. This study was designed to investigate the MPV values in patients with JIA and healthy subjects, and determine the correlation between MPV, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The hospital records of a total of 40 children with JIA, diagnosed using the International League of Associations for Rheumatology (ILAR) criteria, and 40 healthy controls were enrolled into the study. White blood cell count (WBC), platelet count, CRP, ESR, and MPV levels were retrospectively recorded. Children with JIA had significantly higher MPV values (8.28±1.12 fL) compared to the control group (7.53±1.07 fL) (p=0.003). Significant correlations were found between MPV, ESR, and CRP in the JIA group (r=0.676, p
References
- Ravelli A, Martini A. Juvenile idiophatic arthritis. Lancet 2007; 369:767–78
- Colglazier CL, Sutej PG. Laboratory testing in the rheu- matic diseases: a practical review. South Med J 2005; 98:185-91
- Jednacz E, Rutkowska-Sak L. Atherosclerosis in juvenile idiopathic arthritis. Mediators Inflamm 2012;2012:714- 32.
- Coulson EJ, Ng WF, Goff I, Foster HE. Cardiovascular risk in juvenile idiopathic arthritis. Rheumatology (Oxford) 2013; 52:1163-71
- Gear, A.R., and D. Camerini. Platelet chemokines and chemokine receptors: Linking hemostasis, inflammation, and hostdefense. Microcirculation 2003; 10: 335–50
- Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol 2002; 118:787–93
- Kisacik B, Tufan A, Kalyoncu U, et al. Mean Platelet Volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008; 75:291–4
- Yuksel O, Helvaci K, Basar O, et al. An overlooked indica- tor of disease activity in ulcerative colitis: Mean platelet volume. Platelets 2009; 20:277–81
- Klovaite J, Benn M, Yazdanyar S, Nordestgaard BG. High platelet volume and increased risk of myocardial infarc- tion: 39531 participants from the general population. J Thromb Haemost 2011; 9:49–56
- Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovas- cular diseases. Int J Clin Pract 2009; 63:1509–15
- Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 3:390–2
- Alkady EA, Helmy HA, Mohamed-Hussein AA. Assessment of cardiac and pulmonary function in children with ju- venile idiopathic arthritis. Rheumatol Int 2012; 32:39-46
- Kavanaugh A. The role of the laboratory in the evaluation of rheumatic diseases. Clin Cornerstone 1999; 2:11–25
- Wu JF, Yang YH, Wang LC, Lee JH, Shen EY, Chiang BL. Comparative usefulness of C-reactive protein and eryth- rocyte sedimentation rate in juvenile rheumatoid arthri- tis. Clin Exp Rheumatol 2007; 25:782-5
- Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: A systemic review and meta-analysis. J Thromb Haemost 2010; 8:148–56
- Schmitt-Sody M, Metz P, Gottschalk O, et al. Platelet P-selectin is significantly involved in leukocyte-endothe- lial cell interaction in murine antigen-induced arthritis. Platelets 2007; 18:365–72
- Waguri-Nagaya Y, Otsuka T, Sugimura I, et al. Synovial inflammation and hyperplasia induced by gliostatin/ plateletderived endothelial cell growth factor in rabbit knees. Rheumatol Int 2000; 20:13–9
- Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volüme with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 2010; 9:45–50
- M. Yilmaz, S. G. Kendirli, D. Altintas, G. Bingol, and B. Antmen. Cytokine levels in serum of patients with juve- nile rheumatoid arthritis. Clinical Rheumatology 2001; 20: 30–5
- Gasparyan AY, Ayvazyan L, Mikhailidis DM, Kitas GD. Mean platelet volume: A link between thrombosis and inflam- mation? Curr Pharm Des 2011;17:47–58
- Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood 1988; 72:1–8
- Yazici S, Yazici M, Erer B, et al. The platelet indices in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity. Platelets 2010; 21:122–5.
Abstract
Juvenil idyopatik artrit (JİA) çocuklarda en sık görülen kronik enflamatuvar artrittir. Ortalama platelet hacmi (OPH) platelet büyüklüğünün bir göstergesidir ve çeşitli hastalıklarda bir enflamasyon belirteci olarak araştırılmıştır. Bu çalışma JİA’ lı hastalarda ve sağlıklı bireylerde OPH düzeylerini araştırmak ve OPH, C-reaktif protein (CRP) ve eritrosit sedimantasyon hızı (ESR) arasındaki ilişkiyi belirlemek için tasarlanmıştır. Bu çalışmaya Uluslararası Romatoloji Dernekleri Ligi (ILAR) kriterlerine göre JIA tanısı konan 40 çocuğun hastane kayıtları ve 40 sağlıklı kontrol grubu dahil edildi. Beyaz kan hücresi sayısı (WBC), trombosit sayısı, CRP, ESH ve OPH düzeyleri retrospektif kaydedildi. JIA'lı çocuklarda OPH değerleri (8.28±1.12 fL) kontrol grubuna(7.53±1.07 fL) göre anlamlı derecede yüksek idi (p=0.003). JIA grubunda OPH ile ESR ve CRP arasında anlamlı korelasyon bulunmuştur (r = 0.676, p <0.001 ve r = 0.430, p <0.006). Buna ek olarak, JİA’lı hastalarda OPH ile trombosit sayımı arasında negatif korelasyon bulunmuştur (r = -0,818, p <0.001). Hasta ve kontrol grubu arasında WBC değerleri açısından anlamlı bir fark yoktu (p> 0.05). Bizim sonuçlarımız, pediatrik JİA hastalarında OPH düzeylerinin yararlı bir enflamasyon belirteci ve ateroskleroz riski için bir prognostik faktör olabileceğini düşündürmektedir
References
- Ravelli A, Martini A. Juvenile idiophatic arthritis. Lancet 2007; 369:767–78
- Colglazier CL, Sutej PG. Laboratory testing in the rheu- matic diseases: a practical review. South Med J 2005; 98:185-91
- Jednacz E, Rutkowska-Sak L. Atherosclerosis in juvenile idiopathic arthritis. Mediators Inflamm 2012;2012:714- 32.
- Coulson EJ, Ng WF, Goff I, Foster HE. Cardiovascular risk in juvenile idiopathic arthritis. Rheumatology (Oxford) 2013; 52:1163-71
- Gear, A.R., and D. Camerini. Platelet chemokines and chemokine receptors: Linking hemostasis, inflammation, and hostdefense. Microcirculation 2003; 10: 335–50
- Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol 2002; 118:787–93
- Kisacik B, Tufan A, Kalyoncu U, et al. Mean Platelet Volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008; 75:291–4
- Yuksel O, Helvaci K, Basar O, et al. An overlooked indica- tor of disease activity in ulcerative colitis: Mean platelet volume. Platelets 2009; 20:277–81
- Klovaite J, Benn M, Yazdanyar S, Nordestgaard BG. High platelet volume and increased risk of myocardial infarc- tion: 39531 participants from the general population. J Thromb Haemost 2011; 9:49–56
- Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovas- cular diseases. Int J Clin Pract 2009; 63:1509–15
- Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 3:390–2
- Alkady EA, Helmy HA, Mohamed-Hussein AA. Assessment of cardiac and pulmonary function in children with ju- venile idiopathic arthritis. Rheumatol Int 2012; 32:39-46
- Kavanaugh A. The role of the laboratory in the evaluation of rheumatic diseases. Clin Cornerstone 1999; 2:11–25
- Wu JF, Yang YH, Wang LC, Lee JH, Shen EY, Chiang BL. Comparative usefulness of C-reactive protein and eryth- rocyte sedimentation rate in juvenile rheumatoid arthri- tis. Clin Exp Rheumatol 2007; 25:782-5
- Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: A systemic review and meta-analysis. J Thromb Haemost 2010; 8:148–56
- Schmitt-Sody M, Metz P, Gottschalk O, et al. Platelet P-selectin is significantly involved in leukocyte-endothe- lial cell interaction in murine antigen-induced arthritis. Platelets 2007; 18:365–72
- Waguri-Nagaya Y, Otsuka T, Sugimura I, et al. Synovial inflammation and hyperplasia induced by gliostatin/ plateletderived endothelial cell growth factor in rabbit knees. Rheumatol Int 2000; 20:13–9
- Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volüme with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 2010; 9:45–50
- M. Yilmaz, S. G. Kendirli, D. Altintas, G. Bingol, and B. Antmen. Cytokine levels in serum of patients with juve- nile rheumatoid arthritis. Clinical Rheumatology 2001; 20: 30–5
- Gasparyan AY, Ayvazyan L, Mikhailidis DM, Kitas GD. Mean platelet volume: A link between thrombosis and inflam- mation? Curr Pharm Des 2011;17:47–58
- Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood 1988; 72:1–8
- Yazici S, Yazici M, Erer B, et al. The platelet indices in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity. Platelets 2010; 21:122–5.
Details
| Primary Language | English |
|---|---|
| Journal Section | Original Articles |
| Authors | |
| Publication Date | December 1, 2014 |
| Published in Issue | Year 2014 Volume: 11 Issue: 4 |