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Ocular Surface Findings in Chronic Renal Failure

Year 2014, Volume: 11 Issue: 3, 148 - 152, 01.09.2014
https://doi.org/10.15197/sabad.1.11.60

Abstract

The purpose of this study was to describe the ocular surface findings in chronic renal failure (CRF). Sixty eyes of 30 patients with CRF group and 70 eyes of 35 healthy subjects were evaluated. Schirmer-I, tear film break-up time tests and conjunctival impression cytology were performed in addition to complete ophthalmologic examination. The presence of dry eye symptoms and conjunctival calcification were noted. The groups were age and gender matched. The mean break-up time was 10.3±3.1 in group-1 and 11.2±1.7 seconds in the group-2 (p=0.03). The mean Schirmer score was 11.2±2.8 mm and 12.0±1.7 mm in the CRF and control group (p=0.095), respectively. In CRF group, conjunctival impression cytology was revealed as grade-0 findings in 16 eyes, grade 1 findings in 41 eyes and grade 2 findings in 3 eyes, in control group, it was revealed grade-0 findings in 48 eyes, grade 1 findings in 22 eyes and showed no changed in grade 2 (p

References

  • Diaz-Couchoud P, Bordas FD, Garcia JRF, Camps EM, Carceller A. Corneal disease in patients with chronic renal insufficiency undergoing hemodialysis. Cornea 2001;20:695-702.
  • Porter R, Crombie AL. Corneal and conjunctival cal- cification in chronic renal failure. Br J Ophthalmol 1973;57:339-43.
  • Klaassen-Broekema N, van Bijsterveld OP. The red eye of renal failure: a crystal induced inflammation? Br J Ophthalmol 1992;76:578-581.
  • Dursun D, Demirhan B, Oto S, Aydin P. Impression cytolo- gy of the conjunctival epithelium in patients with chronic renal failure. Br J Ophthalmol 2000;84:1225–27.
  • Tomazzoli L, De Natale R, Lupo A, Parolini B. Visual acu- ity disturbances in chronic renal failure. Ophthalmologica 2000;214:403–5.
  • Ozdemir M, Bakaris S, Ozdemir G, Buyukbese MA, Cetinkaya A. Ocular surface disorders and tear function
  • Table Grading of conjunctival impression cytology
  • CIC Grades n(%) 1 2 p value Control group CRF group 16 (27) 41 (68) 3(5) changes in patients with chronic renal failure. Can J Ophthalmol 2004;39:526–32.
  • Komine N, Ohnari K, Murakami M, Kawata K, Suzuka K, Nakamata T. Ischemic ocular motor nerve palsy in three patients with end-stage renal disease. J UOEH 2006;28:57–64.
  • Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol 1977;84:798–801.
  • Paridaens ADA, McCartney ACE, Curling OM, Lyons CJ, Hungerford JL. Impression cytology of conjunctival mela- nosis and melanoma. Br J Ophthalmol 1992;76:198–201.
  • Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface: dry eye states. Arch Ophthalmol 1983;101:1869–72.
  • Kinoshita S, Kiorpes TC, Friend J, Thoft RA. Goblet cell density in ocular surface disease. A better indicator than tear mucin. Arch Ophthalmol 1983;101:1284-7.
  • Bron AJ, Evans VE, Smith JA. Grading of corneal and con- junctival staining in the context of other dry eye tests. Cornea 2003;22:640–50.
  • Nelson JD. Impression cytology. Cornea 1988;7:71–81.
  • Abrams JD. Corneal and other findings in patients on in- termittent dialysis for renal failure. Proc Roy Soc Med 1966;59:533-4.
  • Chestler RJ, De Venecia G. Calcific eyelid margin lesions in chronic renal failure. Am J Ophthalmol 1989;107:556–7.
  • Aktaş Z, Ozdek S, Asli Dinç U, et al. Alterations in ocu- lar surface and corneal thickness in relation to metabolic control in patients with chronic renal failure. Nephrology 2007;12:380-5.
  • Demco TA, McCormick AQ, Richards JSF. Conjunctival and corneal changes in chronic renal failure. Can J Ophthalmol 1974;9:208–13.
  • Hsiao CH, Chao A, Chu SY, et al. Association of severity of conjunctival and corneal calcification with all-cause 1-year mortality in maintenance haemodialysis patients. Nephrol Dial Transplant 2011;26:1016-23.
  • Manning FJ, Wehrly SR, Foulks GN. Patient tolerance and ocular surface staining characteristics of lissamine green versus rose bengal. Ophthalmology 1995;102:1953–7.
  • Feenstra RP, Tseng SC. What’s actually stained by rose bengal? ArchOphthalmol 1992;110:984–93.
  • Feenstra RP, Tseng SC. Comparison of fluorescein and rose bengal staining. Ophthalmology 1995;102:1953–7.
  • Norn MS. Lissamine green. Vital staining of cornea and conjunctiva. Acta Ophthalmol 1973;51:483–91.

Ocular Surface Findings in Chronic Renal Failure

Year 2014, Volume: 11 Issue: 3, 148 - 152, 01.09.2014
https://doi.org/10.15197/sabad.1.11.60

Abstract

Çalışmamızdaki amacımız kronik böbrek yetmezliği (KBY)’nde oküler yüzey bulgularını tanımlamaktır. KBY bulunan 30 hastanın 60 gözü ve sağlıklı 35 olgunun 70 gözü değerlendirildi. Tam bir oftalmolojik muayenenin yanında Schirmer I testi, göz yaşı kırılma zamanı ve konjunktival impresyon sitolojisi yapıldı. Konjunktival kalsifikasyon ve kuru göz bulguları kaydedildi. Gruplar yaş ve cinsiyet uyumlu idi. Ortalama göz yaşı kırılma zamanı KBY grubunda 10.3±3.1 ve kontrol grubunda 11.2±1.7 saniye idi (p=0.03). Schirmer skoru KBY grubunda 11.2±2.8 ve kontrol grubunda 12.0±1.7 mm olarak ölçüldü (p=0.095). İmpresyon sitolojisi bulguları KBY grubunda 16 gözde grade 0, 41 gözde grade 1 ve 3 gözde grade 2 iken kontrol grubunda 48 gözde grade 0, 22 gözde grade 1 olarak izlendi (p<0.001). Konjunktival kalsifikasyon değişimleri KBY grubunda 18 gözde grade 0, 34 gözde grade 1 ve 8 gözde grade 2 iken kontrol grubunda tüm olgular grade 0 olarak tespit edildi (p<0.001). Kaşıntı (%45), kızarıklık (%95) ve yabancı cisim hissi (%83) KBY grubunda konjunktival kalsifikasyon olan olgularda daha sık olarak görüldü (p<0.001). Kronik böbrek yetmezliğinde göz yaşı üretimi normal olmasına rağmen kalsifikasyonlar ve göz yaşı kalitesinin bozulmasına bağlı olarak normal bireylere göre oküler yüzey şikayetleri daha fazla olmaktadır

References

  • Diaz-Couchoud P, Bordas FD, Garcia JRF, Camps EM, Carceller A. Corneal disease in patients with chronic renal insufficiency undergoing hemodialysis. Cornea 2001;20:695-702.
  • Porter R, Crombie AL. Corneal and conjunctival cal- cification in chronic renal failure. Br J Ophthalmol 1973;57:339-43.
  • Klaassen-Broekema N, van Bijsterveld OP. The red eye of renal failure: a crystal induced inflammation? Br J Ophthalmol 1992;76:578-581.
  • Dursun D, Demirhan B, Oto S, Aydin P. Impression cytolo- gy of the conjunctival epithelium in patients with chronic renal failure. Br J Ophthalmol 2000;84:1225–27.
  • Tomazzoli L, De Natale R, Lupo A, Parolini B. Visual acu- ity disturbances in chronic renal failure. Ophthalmologica 2000;214:403–5.
  • Ozdemir M, Bakaris S, Ozdemir G, Buyukbese MA, Cetinkaya A. Ocular surface disorders and tear function
  • Table Grading of conjunctival impression cytology
  • CIC Grades n(%) 1 2 p value Control group CRF group 16 (27) 41 (68) 3(5) changes in patients with chronic renal failure. Can J Ophthalmol 2004;39:526–32.
  • Komine N, Ohnari K, Murakami M, Kawata K, Suzuka K, Nakamata T. Ischemic ocular motor nerve palsy in three patients with end-stage renal disease. J UOEH 2006;28:57–64.
  • Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol 1977;84:798–801.
  • Paridaens ADA, McCartney ACE, Curling OM, Lyons CJ, Hungerford JL. Impression cytology of conjunctival mela- nosis and melanoma. Br J Ophthalmol 1992;76:198–201.
  • Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface: dry eye states. Arch Ophthalmol 1983;101:1869–72.
  • Kinoshita S, Kiorpes TC, Friend J, Thoft RA. Goblet cell density in ocular surface disease. A better indicator than tear mucin. Arch Ophthalmol 1983;101:1284-7.
  • Bron AJ, Evans VE, Smith JA. Grading of corneal and con- junctival staining in the context of other dry eye tests. Cornea 2003;22:640–50.
  • Nelson JD. Impression cytology. Cornea 1988;7:71–81.
  • Abrams JD. Corneal and other findings in patients on in- termittent dialysis for renal failure. Proc Roy Soc Med 1966;59:533-4.
  • Chestler RJ, De Venecia G. Calcific eyelid margin lesions in chronic renal failure. Am J Ophthalmol 1989;107:556–7.
  • Aktaş Z, Ozdek S, Asli Dinç U, et al. Alterations in ocu- lar surface and corneal thickness in relation to metabolic control in patients with chronic renal failure. Nephrology 2007;12:380-5.
  • Demco TA, McCormick AQ, Richards JSF. Conjunctival and corneal changes in chronic renal failure. Can J Ophthalmol 1974;9:208–13.
  • Hsiao CH, Chao A, Chu SY, et al. Association of severity of conjunctival and corneal calcification with all-cause 1-year mortality in maintenance haemodialysis patients. Nephrol Dial Transplant 2011;26:1016-23.
  • Manning FJ, Wehrly SR, Foulks GN. Patient tolerance and ocular surface staining characteristics of lissamine green versus rose bengal. Ophthalmology 1995;102:1953–7.
  • Feenstra RP, Tseng SC. What’s actually stained by rose bengal? ArchOphthalmol 1992;110:984–93.
  • Feenstra RP, Tseng SC. Comparison of fluorescein and rose bengal staining. Ophthalmology 1995;102:1953–7.
  • Norn MS. Lissamine green. Vital staining of cornea and conjunctiva. Acta Ophthalmol 1973;51:483–91.
There are 24 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Fatih Mehmet Türkcü This is me

Gül Türkcü This is me

Gokhan Temiz This is me

Harun Yüksel This is me

Mehmet Taş This is me

Nuretttin Tunç This is me

Publication Date September 1, 2014
Published in Issue Year 2014 Volume: 11 Issue: 3

Cite

APA Türkcü, F. M., Türkcü, G., Temiz, G., Yüksel, H., et al. (2014). Ocular Surface Findings in Chronic Renal Failure. European Journal of General Medicine, 11(3), 148-152. https://doi.org/10.15197/sabad.1.11.60
AMA Türkcü FM, Türkcü G, Temiz G, Yüksel H, Taş M, Tunç N. Ocular Surface Findings in Chronic Renal Failure. European Journal of General Medicine. September 2014;11(3):148-152. doi:10.15197/sabad.1.11.60
Chicago Türkcü, Fatih Mehmet, Gül Türkcü, Gokhan Temiz, Harun Yüksel, Mehmet Taş, and Nuretttin Tunç. “Ocular Surface Findings in Chronic Renal Failure”. European Journal of General Medicine 11, no. 3 (September 2014): 148-52. https://doi.org/10.15197/sabad.1.11.60.
EndNote Türkcü FM, Türkcü G, Temiz G, Yüksel H, Taş M, Tunç N (September 1, 2014) Ocular Surface Findings in Chronic Renal Failure. European Journal of General Medicine 11 3 148–152.
IEEE F. M. Türkcü, G. Türkcü, G. Temiz, H. Yüksel, M. Taş, and N. Tunç, “Ocular Surface Findings in Chronic Renal Failure”, European Journal of General Medicine, vol. 11, no. 3, pp. 148–152, 2014, doi: 10.15197/sabad.1.11.60.
ISNAD Türkcü, Fatih Mehmet et al. “Ocular Surface Findings in Chronic Renal Failure”. European Journal of General Medicine 11/3 (September 2014), 148-152. https://doi.org/10.15197/sabad.1.11.60.
JAMA Türkcü FM, Türkcü G, Temiz G, Yüksel H, Taş M, Tunç N. Ocular Surface Findings in Chronic Renal Failure. European Journal of General Medicine. 2014;11:148–152.
MLA Türkcü, Fatih Mehmet et al. “Ocular Surface Findings in Chronic Renal Failure”. European Journal of General Medicine, vol. 11, no. 3, 2014, pp. 148-52, doi:10.15197/sabad.1.11.60.
Vancouver Türkcü FM, Türkcü G, Temiz G, Yüksel H, Taş M, Tunç N. Ocular Surface Findings in Chronic Renal Failure. European Journal of General Medicine. 2014;11(3):148-52.