Bellini Duct Carcinoma of the Kidney and Liver Metastasis

Year 2014, Volume: 11 Issue: 12, - , 21.03.2016

Suat Keskin

https://doi.org/10.15197/sabad.1.11.20

Abstract

We present clinical and radiological findings in a case of bellini duct carcinoma. This is a rare and aggressive kidney cancer originating from distal renal tubule. The patient underwent transperitoneal radical nephrectomy and the pathological report certified the diagnosis. Control computed tomography scan showed normal findings. But magnetic resonance imaging showed a heterogenous solid mass that is seen hypointense in T1 weighted imaging and hyperintensity in fat suppressed T2 weighted imaging in the liver. Microscopic examination revealed a deterioration structure, desmoplastic appearance and atypical cells with large hyperchromatic nucleus and evidence nucleolus. The histopathological diagnosis was a metastasis of bellini duct carcinoma.

Keywords

Bellini duct carcinoma, radical nephrectomy, heterogenous solid mass, fat suppressed T2 weighted imaging, desmoplastic appearance

Bellini Duct Carcinoma of the Kidney and Liver Metastasis

Abstract

Bu vakada Bellini ductus karsinomunun (BDC) klinik ve radyolojik bulgularını sunmaktayız. Bellini duktus karsinomu distal renal tübülden köken alan agresif seyirli bir böbrek tümörüdür. Hastaya transperitoneal radikal nefrektomi uygulandı ve patolojik bugular tanıyı destekledi. Kontrol bilgisayarlı tomografide (BT) normal bulgular izlendi. Fakat manyetik rezonans incelemede (MRI) karaciğerde T1 ağırlıklı sekanslarda hipointens ve yağ baskılı T2 ağırlıklı sekanslarda hiperintens görünümde heterojen solid kitle izlendi. Mikroskopik incelemede detoryasyon gösteren yapılar, dezmoplastik görünüm ve hiperkromatik büyük nükleuslu ve nükleouslu atipik hücreler izlendi. Histopatolojik tanı BDC matastazını doğruladı

Keywords

Bellini duktus karsinomu, radikal nefrektomi, heterojen solid kitle, yağ baskılanmış T2 ağırlıklı görüntüleme, dezmoplastik görünüm

References

• Milowsky MI, Rosmarin A, Tickoo SK, Papanicolau N, Nanus DM. Active chemotherapy for collecting duct carcinoma of the kidney: a case report and review of the leterature. Cancer 2002; 94: 111-6.
• Pickhardt PJ, Lonergan GJ, Davis CJ, Kashitani N, Wagner BJ. Infiltrative renal lesions: radiologic-pathologic corre- lation. RadioGraphics 2000; 20: 215–43.
• Srigley JR, Eble JN. Collecting duct carcinoma of kidney. Semin Diagn Pathol 1998; 15: 54-67.
• Verdorfer I, Culig Z, Hobisch A, et al. Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridization. Int J Oncol 1998; 13(3): 461–4.
• Auguet T, Molina JC, Lorenzo A, et al. Synchronous renal cell carcinoma and Bellini duct carcinoma: a case report on a rare coincidence. World J Urol 2000; 18(6): 449–51.
• Dobronski P, Czaplicki M, Kozminska E, Pykalo R. Collecting (Bellini) duct carcinoma of the kidney – clinical, radio- logic and immunohistochemical findings. Int Urol Nephrol 1999;31(5): 601–9.
• Kennedy SM, Merino MJ, Linehan WM. Collecting duct car- cinoma of the kidney. Hum Pathol 1990; 21: 449.
• Chao D, Zisman A, Pantuck AJ, et al. Collecting duct renal cell carcinoma: clinical study of a rare tumor. J Urol 2002; 167: 71–4.
• Gollob JA, Upton MP, DeWolf WC, Atkins MB. Long-term remission in a patient with metastatic collecting duct carcinoma treated with taxol/carboplatin and surgery. Urology 2001; 58: 1058.
• Vecchione A, Galetti TP, Gardiman M, et al. Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases. BMC Urol 2004; 4: 11.
• Peyromaure M, ThiounnN, Scotte F, Vieillefond A,Debre B,Oudard S. Collecting duct carcinoma of the kidney: aclinicopathological study of 9 cases. J Urol 2003;170: 1138–40.
• Kirkali Z, Celebi I, Akan G, Yorukoglu K. Bellini duct (col- lecting duct) carcinoma of the kidney. Urology 1996; 47: 921–3.
• Antonelli A, Portesi E, Cozzoli A, et al. The collecting duct carcinoma of the kidney: a cytogenetical study. Eur Urol 2003; 43: 680–5.
• Mejean A, Roupret M, Larousserie F, Hopirtean V, Thiounn N, Dufour B. Is there a place for radical nephrectomyin the presence of metastatic collecting duct (Bellini) carci- noma? J Urol 2003;169:1287–90.
• Matz LR, Latham BI, Fabian VA, Vivian JB. Collecting duct carcinoma of the kidney: a report of three cases and re- view of the literature. Pathology 1997; 29: 354–9.
• Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S, Igarashi T. Collecting duct (Bellini duct) renal cell car- cinoma: a nationwide survey in Japan. J Urol 2006; 176: 40–3.
• De Diego RE, Pascual SC, Gutierrez BJL, et al. Bellini’s carcinoma. Our experience. Arch Esp Urol 2000; 53(7): 611–6.
• Fukuya T, Honda H, Goto K, et al: Computed tomographic findings of Bellini duct carcinoma of the kidney. J Comput Assist Tomogr 1996; 20: 399–403.
• Dimopoulos MA, Logothetis CJ, Markowitz A, Sella A, Amato R, Ro J. Collecting duct carcinoma of the kidney. Br J Urol 1993; 71: 388–91.
• Nomura M, Nagaoka A, Ueno Y, et al. Bellini duct car- cinoma: a case report. Nishinihon Hinyokika 1994; 56: 1078–81.
• Staehler M, Schöppler G, Haseke N, et al. Carcinoma of the collecting ducts of Bellini of the kidney: adjuvant chemotherapy followed by multikinase inhibition with sunitinib. Clin Genitourin Cancer 2009; 7(1): 58-61.
• Natsume O, Ozono S, Futami T, Ohta M. Bellini Duct Carcinoma: a Case Report. Jpn J Clin Oncol 1997;27(2)107– 110.
• Argani P, Rosai J. Thymoma arising with a thymolipoma. Histopathology 1998;32: 5568-78.