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Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize

Year 2014, Volume: 11 Issue: 12, - , 21.03.2016
https://doi.org/10.15197/sabad.1.11.31

Abstract

Nodular liver lesions commonly represent solid tumour metastases. However, haematological neoplasms should also be considered as primary cause. Extramedullary infiltration of multiple myeloma with hepatic invasion at diagnosis is uncommon. We describe an unusual case of a woman presenting with multiple liver lesions initially suggesting disseminated solid tumour disease. She appeared to have widespread plasmablastic myeloma, an aggressive subtype of multiple myeloma, instead.

References

  • Palumbo A, Anderson K. Multiple myeloma. N Engl J Med 2011;364:1046-60.
  • Raab MS, Podar K, Breitkreutz I, Richardson PG, Anderson KC. Multiple myeloma. Lancet 2009;374:324-39.
  • Rajkumar SV, Fonseca R, Lacy MQ, et al. Plasmablastic morphology is an independent predictor of poor survival after autologous stem-cell transplantation for multiple myeloma. J Clin Oncol 1999;17:1551-7.
  • Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood 2008;111:2521-6.
  • Damaj G, Mohty M, Vey N, et al. Features of extramed- ullary and extraosseous multiple myeloma: a report of 19 patients from a single center. Eur J Haematol 2004;73:402-6.
  • Oshima K, Kanda Y, Nannya Y, et al. Clinical and patho- logic findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol 2001;67:1-5.
  • Patlas M, Khalili K, Dill-Macky MJ, Wilson SR. Spectrum of imaging findings in abdominal extraosseous myeloma. AJR Am J Roentgenol 2004;183:929-32.
  • Perez-Soler R, Esteban R, Allende E, Tornos Salomo C, Julia A, Guardia J. Liver involvement in multiple myelo- ma. Am J Hematol 1985;20:25-9.
  • Simmons MZ, Miller JA, Levine CD, Glucksman WJ, Wachsberg RH. Myelomatous involvement of the liv- er: unusual ultrasound appearance. J Clin Ultrasound 1997;25:145-8.
  • Wu XN, Zhao XY, Jia JD. Nodular liver lesions involving multiple myeloma: a case report and literature review. World J Gastroenterol 2009;15:1014-7.
  • Kapadia SB. Multiple myeloma: a clinicopathologic study of 62 consecutively autopsied cases. Medicine (Baltimore) 1980;59:380-92.
  • Talamo G, Cavallo F, Zangari M, et al. Clinical and biologi- cal features of multiple myeloma involving the gastroin- testinal system. Haematologica 2006;91:964-7.
  • Thiruvengadam R, Penetrante RB, Goolsby HJ, Silk YN, Bernstein ZP. Multiple myeloma presenting as space-occu- pying lesions of the liver. Cancer 1990;65:2784-6.
  • Yoon YS, Min YH, Chon CY, et al. Liver involvement in mul- tiple myeloma proven by peritoneoscopy--a case report. Yonsei Med J 1993;34:90-7.
  • Heckmann M, Uder M, Grgic A, Adrian N, Bautz W, Heinrich M. Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography--case re- port. Rontgenpraxis 2008;56:249-53.
  • Greipp PR, Raymond NM, Kyle RA, O'Fallon WM. Multiple myeloma: significance of plasmablastic subtype in mor- phological classification. Blood 1985;65:305-10.
  • Albarracin F, Fonseca R. Plasma cell leukemia. Blood Rev 2011;25:107-12.

Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize

Year 2014, Volume: 11 Issue: 12, - , 21.03.2016
https://doi.org/10.15197/sabad.1.11.31

Abstract

Nodüler karaciğer lezyonları genellikle solid tümör metastazını gösterir. Bununla birlikte, hematolojik neoplazmalar bunların ana nedeni olarak kabul edilmelidir. Tanıda hepatik invazyonlu multipl miyelomun ekstrameduller infiltrasyonu oldukça nadirdir. Biz başlangıçta yaygın solid tümör hastalığı olan multipl karaciğer lezyonları ile başvuran bir kadın olgu sunulmaktadır. Olguda yaygın plazmablastik miyelom tutulumu mevcuttur

References

  • Palumbo A, Anderson K. Multiple myeloma. N Engl J Med 2011;364:1046-60.
  • Raab MS, Podar K, Breitkreutz I, Richardson PG, Anderson KC. Multiple myeloma. Lancet 2009;374:324-39.
  • Rajkumar SV, Fonseca R, Lacy MQ, et al. Plasmablastic morphology is an independent predictor of poor survival after autologous stem-cell transplantation for multiple myeloma. J Clin Oncol 1999;17:1551-7.
  • Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood 2008;111:2521-6.
  • Damaj G, Mohty M, Vey N, et al. Features of extramed- ullary and extraosseous multiple myeloma: a report of 19 patients from a single center. Eur J Haematol 2004;73:402-6.
  • Oshima K, Kanda Y, Nannya Y, et al. Clinical and patho- logic findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol 2001;67:1-5.
  • Patlas M, Khalili K, Dill-Macky MJ, Wilson SR. Spectrum of imaging findings in abdominal extraosseous myeloma. AJR Am J Roentgenol 2004;183:929-32.
  • Perez-Soler R, Esteban R, Allende E, Tornos Salomo C, Julia A, Guardia J. Liver involvement in multiple myelo- ma. Am J Hematol 1985;20:25-9.
  • Simmons MZ, Miller JA, Levine CD, Glucksman WJ, Wachsberg RH. Myelomatous involvement of the liv- er: unusual ultrasound appearance. J Clin Ultrasound 1997;25:145-8.
  • Wu XN, Zhao XY, Jia JD. Nodular liver lesions involving multiple myeloma: a case report and literature review. World J Gastroenterol 2009;15:1014-7.
  • Kapadia SB. Multiple myeloma: a clinicopathologic study of 62 consecutively autopsied cases. Medicine (Baltimore) 1980;59:380-92.
  • Talamo G, Cavallo F, Zangari M, et al. Clinical and biologi- cal features of multiple myeloma involving the gastroin- testinal system. Haematologica 2006;91:964-7.
  • Thiruvengadam R, Penetrante RB, Goolsby HJ, Silk YN, Bernstein ZP. Multiple myeloma presenting as space-occu- pying lesions of the liver. Cancer 1990;65:2784-6.
  • Yoon YS, Min YH, Chon CY, et al. Liver involvement in mul- tiple myeloma proven by peritoneoscopy--a case report. Yonsei Med J 1993;34:90-7.
  • Heckmann M, Uder M, Grgic A, Adrian N, Bautz W, Heinrich M. Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography--case re- port. Rontgenpraxis 2008;56:249-53.
  • Greipp PR, Raymond NM, Kyle RA, O'Fallon WM. Multiple myeloma: significance of plasmablastic subtype in mor- phological classification. Blood 1985;65:305-10.
  • Albarracin F, Fonseca R. Plasma cell leukemia. Blood Rev 2011;25:107-12.
There are 17 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Dennis Boumans This is me

Ronald Hoekstra This is me

Anouk Krukkert-alberink This is me

Bart Schot This is me

Publication Date March 21, 2016
Published in Issue Year 2014 Volume: 11 Issue: 12

Cite

APA Boumans, D., Hoekstra, R., Krukkert-alberink, A., Schot, B. (2016). Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize. European Journal of General Medicine, 11(12). https://doi.org/10.15197/sabad.1.11.31
AMA Boumans D, Hoekstra R, Krukkert-alberink A, Schot B. Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize. European Journal of General Medicine. March 2016;11(12). doi:10.15197/sabad.1.11.31
Chicago Boumans, Dennis, Ronald Hoekstra, Anouk Krukkert-alberink, and Bart Schot. “Plasmablastic Myeloma Presenting With Nodular Liver Lesions: Rare But Important to Recognize”. European Journal of General Medicine 11, no. 12 (March 2016). https://doi.org/10.15197/sabad.1.11.31.
EndNote Boumans D, Hoekstra R, Krukkert-alberink A, Schot B (March 1, 2016) Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize. European Journal of General Medicine 11 12
IEEE D. Boumans, R. Hoekstra, A. Krukkert-alberink, and B. Schot, “Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize”, European Journal of General Medicine, vol. 11, no. 12, 2016, doi: 10.15197/sabad.1.11.31.
ISNAD Boumans, Dennis et al. “Plasmablastic Myeloma Presenting With Nodular Liver Lesions: Rare But Important to Recognize”. European Journal of General Medicine 11/12 (March 2016). https://doi.org/10.15197/sabad.1.11.31.
JAMA Boumans D, Hoekstra R, Krukkert-alberink A, Schot B. Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize. European Journal of General Medicine. 2016;11. doi:10.15197/sabad.1.11.31.
MLA Boumans, Dennis et al. “Plasmablastic Myeloma Presenting With Nodular Liver Lesions: Rare But Important to Recognize”. European Journal of General Medicine, vol. 11, no. 12, 2016, doi:10.15197/sabad.1.11.31.
Vancouver Boumans D, Hoekstra R, Krukkert-alberink A, Schot B. Plasmablastic Myeloma Presenting with Nodular Liver Lesions: Rare but Important to Recognize. European Journal of General Medicine. 2016;11(12).