The Assessment as Bone Mineral Density of Bone Damage in Radiology Workers Occupationally Exposed to Ionizing Radiation

Year 2013, Volume: 10 Issue: 4, 214 - 218, 01.12.2013

Halil Kunt Hayri Dayıoğlu Muhammet Kasım Çaycı Mehmet Korkmaz

Abstract

We examined the effects of occupational ionizing radiation exposure in radiology workers on bone mineral density and serum alkaline phosphates (ALP) levels. 49 subjects, aged between 21-48 years (33.86 years), working in the department of radiology were enrolled to this study. 26 subjects were female and 23 were male. Control group consisted of 40 healthy subjects aged between 22-49 years (mean 33.83) who had never been exposed to radiation; 21 of these were female and 19 male. Venous blood samples were obtained from the radiology workers and control group and serum alkaline phosphatase levels analysis of samples were performed. The bone mineral density (BMD) was assessed in the spine and the hip with a dual-energy x-ray absorptiometry (DEXA) instrument. T-scores of radiology workers was lower than control group significantly (P < 0.01). Serum ALP levels of radiology workers was lower than control group significantly (P < 0.01). T-scores and serum ALP levels of private sector workers were lower than state hospital workers but there was no significantly difference among them (P > 0.05). T-scores of the men at the control group were higher than the women\'s however the case was just the opposite for the work group. In radiology workers exposed to long-term low-dose ionizing radiation has negative effect on bone mineral density and serum ALP levels.

Keywords

Radiation, bone mineral density, serum ALP

The Assessment as Bone Mineral Density of Bone Damage in Radiology Workers Occupationally Exposed to Ionizing Radiation

Abstract

Biz radyoloji çalışanlarında mesleki iyonize radyasyon maruziyetinin kemik mineral yoğunluğu ve serum alkalin fosfotaz (ALP) seviyeleri üzerine etkilerini inceledik. Radyoloji departmanında çalışan, yaşları 21-48 (33.86) arasında değişen 26’sı kadın ve 23’ü erkek toplam 49 radyoloji çalışanı bu çalışma kapsamına alındı. Kontrol grubu, herhangi bir şekilde radyasyona maruz kalmamış sağlıklı, yaşları 22-49 (33.83) arasında değişen 21’i kadın ve 19’u erkek 40 kişiden oluşturuldu. Radyoloji çalışanı ve kontrol grubundaki kişilerin her birinden alınan venöz kan örneklerinden serum alkalin fosfotaz analizleri yapıldı. Omur ve kalça BMD’leri dual enerji x-ray absorptiometry (DEXA) cihazıyla ölçüldü. Radyoloji çalışanlarının T-skorları ve Serum ALP seviyeleri kontrol gruplarından anlamlı olarak düşük bulundu (p<0.01). Özel sektör çalışanlarının T-skorları ve serum ALP seviyeleri devlet hastanesi çalışanlarından düşük bulundu fakat aralarındaki fark anlamlı değildi (P > 0.05). Erkeklerin T-skorları kontrol gruplarında kadınlardan yüksek olmasına rağmen çalışma grubunda bu durumun tam tersi bulundu. Radyoloji çalışanlarında uzun dönem düşük doz iyonize radyasyon maruziyeti kemik mineral yoğunluğu ve serum ALP seviyeleri üzerinde olumsuz etkilidir

Keywords

İyonize radyasyon, kemik mineral yoğunluğu, serum ALP

References

• Tuncel E. Clinic Radiology. 2th. Ed. Bursa: Güneş Nobel Medicine Books, 2002: 25-30.
• McCann DGC. Radiation poisoning: Current concepts in the acute radiation syndrome. Am J Clin Med 2006;3:13-21.
• Fliedner TM, Graessle D, Paulsen C, Reimers K. Structure and function of bone marrow hemopoiesis: Mechanisms of response to ionizing radiation exposure. Cancer Biother Radiopharm 2002;17: 405-26.
• Baxter NN, Habermann EB, Teper JE, Durham SB, Virnig BA. Risk of pelvic fractures in older women following pel- vic irradiation. J Am Med Assoc 2005; 294: 2587-93.
• Ergun H, Howland WJ. Postradiation atrophy of mature bone. CRC Crit Rev Diagn Imaging 1980; 12: 225-43.
• Ogino I, Okamoto N, Ono Y, Kitamura T, Nakayama H. Pelvic insufficiency fractures in postmenopausal woman with advanced cervical cancer treated by radiotherapy. Radiother Oncol 2003; 68: 61-7.
• Yiğit Ş. Biological Effects Of Radiation. Radiation Health ve Safety Department TAEK, 2004.
• Baltas CS, Balanika AP, Raptou PD. Clinical practice guide- lines proposed by the Hellenic Foundation of Osteoporosis for the management of osteoporosis based on DXA re- sults. J Musculoskelet Neuronal Interact 2005; 5: 388-92.
• Kunt H, Dayıoğlu H. The Effects of Radiation on Bone Mineral Density of Radiology Workers Depending on The Device They Use. Eur J Gen Med 2011; 8: 318-22
• Davydova NG. Relation between the levels of mineral components and mechanical properties of the bones in dogs after a single acute whole-body irradiation. Kosm Biol Aviakosm Med 1990; 24: 51-3. p Value 0.000 97.88±37.66