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Multifocal Glioblastoma Multiforme

Year 2012, Volume: 9 Issue: 4, - , 01.12.2012

Abstract

Multicentric gliomas are uncommon lesions but a fascinating clinical and scientific issue. Current opinion ranges from rejection of surgical treatment to its recommendation. We report a case of young adult who presented with one episode of generalized tonic clonic seizures and mild weakness of right hand. Imaging findings were suggestive multiple lesions in the left temporo-parietal area. Surgical decompression was performed for the larger lesion and histopathology was suggestive of glioblastoma multiforme. Based on these findings a diagnosis of multifocal glioblasotma was made. Patient was submitted for radiotherapy. In patients with multiple lesions tissue analysis is critical for treatment planning and to determine the prognosis.

References

  • Chadduck WM, Roycroft D, Brown MW. Multicentric glio- ma as a cause of multiple cerebral lesions. Neurosurgery 1983;13:170-5.
  • Rao KC, Levine H, Itani A, Sajor E, Robinson W. CT find- ings in multicentric glioblastoma: diagnostic-pathologic correlation. J Comput Tomo 1980;4:187-92.
  • Bussone G, Sinatra MG, Boiardi A, Lazzaroni M, Mariani C, Allegranza A. A case of glioblastoma with multiple centers above and below the tentorium. J Neurol 1979;221:187-92.
  • Van Tassel P, Lee YY, Bruner JM. Synchronous and meta- chronous malignant gliomas: CT findings. AJNR Am J Neuroradiol 1988;9:725-32.
  • Djalilian HR, Shah MV, Hall WA. Radiographic incidence of multicentric malignant gliomas. Surg Neurol 1999;51:554-7.
  • Batzdorf U, Malamud N. The problem of multicentric glio- mas. J Neurosurg 1963;20:122-36.
  • Budka H, Podreka I, Reisner T, Zeiler K. Diagnostic and pathomorphological aspects of glioma multiplicity. Neurosurg Rev 1980;3:233-41.
  • Salvati M, Caroli E, Orlando ER, Frati A, Artizzu S, Ferrante L. Multicentric glioma: our experience in 25 pa- tients and critical review of the literature. Neurosurg Rev 2003;26:275-9.
  • Burger PC, Vogel FS, Green SB, Strike TA. Glioblastoma multiforme and anaplastic astrocytoma. Pathologic crite- ria and prognostic implications. Cancer 1985;56:1106-111.
  • Forsyth PA, Kelly PJ, Cascino TL, et al. Radiation necrosis or glioma recurrence: is computer-assisted stereotactic biopsy useful? J Neurosurg 1995;82:436-44.
  • Lafitte F, Morel-Precetti S, Martin-Duverneuil N, et al. Multiple glioblastomas: CT and MR features. Eur Radiol 2001;11:131-6.
  • Kyritsis AP, Levin VA, Yung WK, Leeds NE. Imaging patterns of multifocal gliomas. Eur J Radiol 1993;16:163-70.
  • Balériaux D, Parizel PM, Matos C, David P, Bank WO. Stereotactic indications for neuroradiological differen- tial diagnosis. Acta neurochirurgica 1993;124:31-3.

Multifocal Glioblastoma Multiforme

Year 2012, Volume: 9 Issue: 4, - , 01.12.2012

Abstract

-

References

  • Chadduck WM, Roycroft D, Brown MW. Multicentric glio- ma as a cause of multiple cerebral lesions. Neurosurgery 1983;13:170-5.
  • Rao KC, Levine H, Itani A, Sajor E, Robinson W. CT find- ings in multicentric glioblastoma: diagnostic-pathologic correlation. J Comput Tomo 1980;4:187-92.
  • Bussone G, Sinatra MG, Boiardi A, Lazzaroni M, Mariani C, Allegranza A. A case of glioblastoma with multiple centers above and below the tentorium. J Neurol 1979;221:187-92.
  • Van Tassel P, Lee YY, Bruner JM. Synchronous and meta- chronous malignant gliomas: CT findings. AJNR Am J Neuroradiol 1988;9:725-32.
  • Djalilian HR, Shah MV, Hall WA. Radiographic incidence of multicentric malignant gliomas. Surg Neurol 1999;51:554-7.
  • Batzdorf U, Malamud N. The problem of multicentric glio- mas. J Neurosurg 1963;20:122-36.
  • Budka H, Podreka I, Reisner T, Zeiler K. Diagnostic and pathomorphological aspects of glioma multiplicity. Neurosurg Rev 1980;3:233-41.
  • Salvati M, Caroli E, Orlando ER, Frati A, Artizzu S, Ferrante L. Multicentric glioma: our experience in 25 pa- tients and critical review of the literature. Neurosurg Rev 2003;26:275-9.
  • Burger PC, Vogel FS, Green SB, Strike TA. Glioblastoma multiforme and anaplastic astrocytoma. Pathologic crite- ria and prognostic implications. Cancer 1985;56:1106-111.
  • Forsyth PA, Kelly PJ, Cascino TL, et al. Radiation necrosis or glioma recurrence: is computer-assisted stereotactic biopsy useful? J Neurosurg 1995;82:436-44.
  • Lafitte F, Morel-Precetti S, Martin-Duverneuil N, et al. Multiple glioblastomas: CT and MR features. Eur Radiol 2001;11:131-6.
  • Kyritsis AP, Levin VA, Yung WK, Leeds NE. Imaging patterns of multifocal gliomas. Eur J Radiol 1993;16:163-70.
  • Balériaux D, Parizel PM, Matos C, David P, Bank WO. Stereotactic indications for neuroradiological differen- tial diagnosis. Acta neurochirurgica 1993;124:31-3.
There are 13 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Amit Agrawal This is me

J H Makannavar This is me

J P Shetty This is me

Lathika Shetty This is me

Boby Varkey This is me

Publication Date December 1, 2012
Published in Issue Year 2012 Volume: 9 Issue: 4

Cite

APA Agrawal, A., Makannavar, J. H., Shetty, J. P., Shetty, L., et al. (2012). Multifocal Glioblastoma Multiforme. European Journal of General Medicine, 9(4).
AMA Agrawal A, Makannavar JH, Shetty JP, Shetty L, Varkey B. Multifocal Glioblastoma Multiforme. European Journal of General Medicine. December 2012;9(4).
Chicago Agrawal, Amit, J H Makannavar, J P Shetty, Lathika Shetty, and Boby Varkey. “Multifocal Glioblastoma Multiforme”. European Journal of General Medicine 9, no. 4 (December 2012).
EndNote Agrawal A, Makannavar JH, Shetty JP, Shetty L, Varkey B (December 1, 2012) Multifocal Glioblastoma Multiforme. European Journal of General Medicine 9 4
IEEE A. Agrawal, J. H. Makannavar, J. P. Shetty, L. Shetty, and B. Varkey, “Multifocal Glioblastoma Multiforme”, European Journal of General Medicine, vol. 9, no. 4, 2012.
ISNAD Agrawal, Amit et al. “Multifocal Glioblastoma Multiforme”. European Journal of General Medicine 9/4 (December 2012).
JAMA Agrawal A, Makannavar JH, Shetty JP, Shetty L, Varkey B. Multifocal Glioblastoma Multiforme. European Journal of General Medicine. 2012;9.
MLA Agrawal, Amit et al. “Multifocal Glioblastoma Multiforme”. European Journal of General Medicine, vol. 9, no. 4, 2012.
Vancouver Agrawal A, Makannavar JH, Shetty JP, Shetty L, Varkey B. Multifocal Glioblastoma Multiforme. European Journal of General Medicine. 2012;9(4).