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Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins

Year 2012, Volume: 9 Issue: 3, 183 - 186, 01.09.2012

Hayriye Sayarlıoğlu Reha Erkoç Ekrem Dogan Yasemin Soyoral Ahmet Faik Öner

Abstract

Epidemiological studies indicate that in chronic HD patients, bacterial and viral infection rank second place in mortality and morbidity, behind cardiovascular disease. Chronic hepatitis C virus (HCV) is very prevalent in some Hemodialysis (HD) centers. We have investigated lymphocyte subtype count and immunoglobulin levels in hemodialyzed patient with HCV. We studied 55 patients with end stage renal disease (ESRD) on chronic HD and 21 healty subjects. Patients group included 34 female and 21 male with mean age 46.5±16.1(18-77) years. Serum concentrations of IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. Lymphocyte and lymphocyte subgroups values of HD patients were significant lower than healty persons. IgG, IgM and ALT levels of HCV positive HD patients compared with significant higher than HCV negative HD patients. CD4/CD8 ratios within groups were no differences. Lymphocyte subtype count of between HCV positive and HCV negative HD patients was no differences. IgG and IgM levels of HCV positive HD patients were higher than HCV negative HD patients. High Ig levels were also associated with ALT levels Key words: HCV, hemodialysis, lymphocyte subtype, immunoglobulins

Keywords

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References

  • Neto MC, Draibe SA, Silva AEB, et al. Incidence of and risk factors for hepatitis B virus and hepatitis C virus infec- tion among hemodialysis and CAPD patients: evidence for environmental tranmission. Nephrol Dial Transplant 1995; 10:240-6.
  • Garcia G, Terrault N, Wright TL. Hepatitis C virus in- fection in the immunocomprimised patient. Semin Gastrointestinal Dis 1995; 6:35-45.
  • Bertoletti A and Ferrari C. Kinetics of immune response during HBV and HCV infection. Hepatology 2003; 38:4-13.
  • Weseslindtner L, Neumann-Haefelin C, Viazov S, et al. Acute infection with a single hepatitis C virus strain in dialysis patients: Analysis of adaptive immune response and viral variability. J Hepatol 2009;50:693-704.
  • Caramelo C, Ortiz A, Aguilera B, et al. Liver disease pat- terns in hemodialysis patients with antibodies to hepati- tis C virus. Am J Kidney Dis 1993;22:822-8.
  • Glicklich D, Thung SN, Kapoian T, et al. Comparison of clinical features and liver histology in hepatitis C posi- tive dialysis patients and renal transplant recipients. Am J Gastroenterol 1999; 94:159-63.
  • Niu MT, Coleman PJ, Alter MJ. Multicenter study of hepa- titis C virus infection in chronic hemodialysis patients and hemodialysis center staff members. Am J kidney Dis 1993; 22:568-73
  • Valderrabano F, Jones EHP, Mallick NP. Report of man- agement of renal failure in Europe 14 1993 Nephrol Dial Transplant 1995;10 (S 5):1-25.
  • Martin J, de Sequera P, quiroga JA, et al. Role of he- modialysis and hepatitis C virus infection in spontaneous and induced cytokine production of patients with chronic renal disease. Cytokine 2000; 12:1248-52.
  • Diepolder HM, Zachoval R, Hoffmann RM, et al. Possible mechanism involving T lenfocyte response to non struc- tural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995;346:1006-7.
  • Missale G, Bertoni R, Lamonaca V, et al. Different clinical behaviors of acut hepatitis C virus infection are associ- ated with different vigor of the anti viral celll mediated immune response. J Clin Invest 1996;98:706-14.
  • Lechner F, Wong DK, Dunbar PR, et al. Analysis of success- ful immune responses in persons infected with hepatitis C virus. J Exp Med 2000;191:1499-512.
  • Thimme R Oldach D, Chang KM, et al. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001;194:1395-406.
  • Morales JM, Campistol JM, Andres A, et al. Hepatitis C virus and renal transplantation. Curr Opin Nephrol Hypertens 1998;7:117-83
  • Rico MA, Ruiz S, Subirá D, Barril G, Cigarrán S, Castañón S, Quiroga JA, Selgas R, Carreño V. Virus-specific effector CD4+ T-cell responses in hemodialysis patients with hepa- titis C virus infection. J Med Virol 2004;72:66-74.
  • Rostaing L, Borde JS, Hasle C, et al. Lack of effect of chronic hepatitis C virus infection on T cell cytokine pro- duction in chronic hemodialysis patients. Am J Nephrol 2001, 21:194-9.
  • Sester U, Sester M, Hauk M, et al. T cell activation fol- lows Th1 rather than Th2 pattern in hemodialysis pa- tients. Nephrol Dial Transplant 2000;15:1217-23.
  • Watt K, Uhanova J, Gong Y, et al. Serum immunoglobu- lins predict the extent of hepatic fibrosis in patients with chronic hepatitis C virus infection. J Viral Hepatitis 2004;11:251–6
  • Wang S, Yang T, Zhang J, Xiao J, Peng X. C3/Ig and Ig/C3 two-component-determined circulating immune complex- es (TCIC) in patients with HCV infection. FEMS Immunol Med Microbiol 2003;36:77-82

Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins

Year 2012, Volume: 9 Issue: 3, 183 - 186, 01.09.2012

Hayriye Sayarlıoğlu Reha Erkoç Ekrem Dogan Yasemin Soyoral Ahmet Faik Öner

Abstract

-

Keywords

-

References

  • Neto MC, Draibe SA, Silva AEB, et al. Incidence of and risk factors for hepatitis B virus and hepatitis C virus infec- tion among hemodialysis and CAPD patients: evidence for environmental tranmission. Nephrol Dial Transplant 1995; 10:240-6.
  • Garcia G, Terrault N, Wright TL. Hepatitis C virus in- fection in the immunocomprimised patient. Semin Gastrointestinal Dis 1995; 6:35-45.
  • Bertoletti A and Ferrari C. Kinetics of immune response during HBV and HCV infection. Hepatology 2003; 38:4-13.
  • Weseslindtner L, Neumann-Haefelin C, Viazov S, et al. Acute infection with a single hepatitis C virus strain in dialysis patients: Analysis of adaptive immune response and viral variability. J Hepatol 2009;50:693-704.
  • Caramelo C, Ortiz A, Aguilera B, et al. Liver disease pat- terns in hemodialysis patients with antibodies to hepati- tis C virus. Am J Kidney Dis 1993;22:822-8.
  • Glicklich D, Thung SN, Kapoian T, et al. Comparison of clinical features and liver histology in hepatitis C posi- tive dialysis patients and renal transplant recipients. Am J Gastroenterol 1999; 94:159-63.
  • Niu MT, Coleman PJ, Alter MJ. Multicenter study of hepa- titis C virus infection in chronic hemodialysis patients and hemodialysis center staff members. Am J kidney Dis 1993; 22:568-73
  • Valderrabano F, Jones EHP, Mallick NP. Report of man- agement of renal failure in Europe 14 1993 Nephrol Dial Transplant 1995;10 (S 5):1-25.
  • Martin J, de Sequera P, quiroga JA, et al. Role of he- modialysis and hepatitis C virus infection in spontaneous and induced cytokine production of patients with chronic renal disease. Cytokine 2000; 12:1248-52.
  • Diepolder HM, Zachoval R, Hoffmann RM, et al. Possible mechanism involving T lenfocyte response to non struc- tural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995;346:1006-7.
  • Missale G, Bertoni R, Lamonaca V, et al. Different clinical behaviors of acut hepatitis C virus infection are associ- ated with different vigor of the anti viral celll mediated immune response. J Clin Invest 1996;98:706-14.
  • Lechner F, Wong DK, Dunbar PR, et al. Analysis of success- ful immune responses in persons infected with hepatitis C virus. J Exp Med 2000;191:1499-512.
  • Thimme R Oldach D, Chang KM, et al. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001;194:1395-406.
  • Morales JM, Campistol JM, Andres A, et al. Hepatitis C virus and renal transplantation. Curr Opin Nephrol Hypertens 1998;7:117-83
  • Rico MA, Ruiz S, Subirá D, Barril G, Cigarrán S, Castañón S, Quiroga JA, Selgas R, Carreño V. Virus-specific effector CD4+ T-cell responses in hemodialysis patients with hepa- titis C virus infection. J Med Virol 2004;72:66-74.
  • Rostaing L, Borde JS, Hasle C, et al. Lack of effect of chronic hepatitis C virus infection on T cell cytokine pro- duction in chronic hemodialysis patients. Am J Nephrol 2001, 21:194-9.
  • Sester U, Sester M, Hauk M, et al. T cell activation fol- lows Th1 rather than Th2 pattern in hemodialysis pa- tients. Nephrol Dial Transplant 2000;15:1217-23.
  • Watt K, Uhanova J, Gong Y, et al. Serum immunoglobu- lins predict the extent of hepatic fibrosis in patients with chronic hepatitis C virus infection. J Viral Hepatitis 2004;11:251–6
  • Wang S, Yang T, Zhang J, Xiao J, Peng X. C3/Ig and Ig/C3 two-component-determined circulating immune complex- es (TCIC) in patients with HCV infection. FEMS Immunol Med Microbiol 2003;36:77-82
There are 19 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Hayriye Sayarlıoğlu This is me

Reha Erkoç This is me

Ekrem Dogan This is me

Yasemin Soyoral This is me

Ahmet Faik Öner This is me

Publication Date September 1, 2012
Published in Issue Year 2012 Volume: 9 Issue: 3

Cite

APA Sayarlıoğlu, H., Erkoç, R., Dogan, E., Soyoral, Y., et al. (2012). Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins. European Journal of General Medicine, 9(3), 183-186.
AMA Sayarlıoğlu H, Erkoç R, Dogan E, Soyoral Y, Öner AF. Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins. European Journal of General Medicine. September 2012;9(3):183-186.
Chicago Sayarlıoğlu, Hayriye, Reha Erkoç, Ekrem Dogan, Yasemin Soyoral, and Ahmet Faik Öner. “Lymphocyte Subtype and Immunglobulins Levels in HCV Positive Hemodialysis Pateints HCV, Hemodialysis, Lymphocyte and Immunoglobulins”. European Journal of General Medicine 9, no. 3 (September 2012): 183-86.
EndNote Sayarlıoğlu H, Erkoç R, Dogan E, Soyoral Y, Öner AF (September 1, 2012) Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins. European Journal of General Medicine 9 3 183–186.
IEEE H. Sayarlıoğlu, R. Erkoç, E. Dogan, Y. Soyoral, and A. F. Öner, “Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins”, European Journal of General Medicine, vol. 9, no. 3, pp. 183–186, 2012.
ISNAD Sayarlıoğlu, Hayriye et al. “Lymphocyte Subtype and Immunglobulins Levels in HCV Positive Hemodialysis Pateints HCV, Hemodialysis, Lymphocyte and Immunoglobulins”. European Journal of General Medicine 9/3 (September 2012), 183-186.
JAMA Sayarlıoğlu H, Erkoç R, Dogan E, Soyoral Y, Öner AF. Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins. European Journal of General Medicine. 2012;9:183–186.
MLA Sayarlıoğlu, Hayriye et al. “Lymphocyte Subtype and Immunglobulins Levels in HCV Positive Hemodialysis Pateints HCV, Hemodialysis, Lymphocyte and Immunoglobulins”. European Journal of General Medicine, vol. 9, no. 3, 2012, pp. 183-6.
Vancouver Sayarlıoğlu H, Erkoç R, Dogan E, Soyoral Y, Öner AF. Lymphocyte subtype and immunglobulins levels in HCV positive hemodialysis pateints HCV, hemodialysis, lymphocyte and immunoglobulins. European Journal of General Medicine. 2012;9(3):183-6.