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Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome

Year 2011, Volume: 8 Issue: 4, 273 - 279, 01.12.2011

Erdem Koçak Gülay Koçak Tacettin Örnek Hatice Bakırtaş Hulusi Atmaca Murat Can Taner Bayraktaroğlu Remzi Altın

Abstract

Keywords

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References

  • Guilleminault C. Clinical features and evaluation of ob- structive sleep apnea, In: Kryger MH, Roth T, Dement WC. (Eds.). Principles and practice of sleep medicine, W.B. Saunders, Philadelphia, 1994
  • Young T, Palta M, Dempsey J, Skatrud J, Weber S., Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-5
  • Peled N, Greenberg A, Pillar G Zinder O, Levi N, Lavie P. Contributions of hypoxia and respiratory disturbance index to sympathetic activation and blood pressure in ob- structive sleep apnea syndrome. Am J Hypertens 1998; 11:1284–9
  • Bjorntorp P. Body fat distribution, insulin resistance, and metabolic diseases. Nutrition 1997;13:795–803
  • Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA 1999;282:1523-9
  • Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med 1993;119:655-60
  • Auwerx J, Staels B. Leptin. Lancet 1998;351:737–42
  • Considine RV, Sinha MK, Heiman ML, et al. Serum immu- noreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292–5
  • Masuzaki H, Ogawa Y, Isse N, et al. Human obese gene expression, Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855–8
  • Masuzaki H, Ogawa Y, Sagawa N, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med 1997;100:1029–33
  • Sobhani I, Bado A, Vissuzaine C, et al. Leptin secretion and leptin receptor in the human stomach. Gut 2000;47: 178–83
  • Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition and menopause on plasma con- centrations of leptin. J Clin Endocrinol Metab 1996;81: 3424-7
  • Ip MS, Lam KS, Ho C, Tsang KW, Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 2000;118:580–6
  • Phillips BG, Kato M, Narkiewiczk K, Choe I, Somers WK. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea. Am J Physiol Heart Circ Physiol 2000;279:H234–7
  • Walder K, Lewandowski P, Morton G, et al. Leptin resis- tance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys Obesus. Int J Obes 1999; 23:83-9
  • Fitzpatrick M. Leptin end the obesity hypoventilation syndrome: A leap of faith? Thorax 2002;57:1–2
  • Zirlik S, Hauck T, Fuchs FS, et al. Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome. Med Sci Monit 2011; 17: CR159-64
  • Tokuda F, Sando Y, Matsui H, Koike H, Yokoyama T. Serum levels of adipocytokines, adiponectin and leptin, in pa- tients with obstructive sleep apnea syndrome. Inter Med 2008;47:1843-9
  • Vgontzas AN, Papanicolaou DA, Bixler EO et al. Sleep ap- nea and daytime sleepiness and fatigue: Relation to vis- ceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 2000;85:1151–8
  • Ozturk L, Unal M, Tamer L, Celikoglu F. The association of the severity of obstructive sleep apnea with plasma leptin levels. Arch Otolaryngol Head Neck Surg 2003;129: 538-40
  • Sanner BM, Kollhosser P, Buechner N, Zidek W, Tepel M. Influence of treatment on leptin levels in patients with obstructive sleep apnea. Eur Respir J 2004;23:601-4
  • Harsch IA, Konturek PC, Koebnick C, et al. Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. Eur Respir J 2003;22:251-7
  • Schafer H, Pauleit D, Sudhop T, Gouni-Berthold I, Ewig S, Berthold HK. Body fat distribution, serum Leptin, and cardiovascular risk factors in men with obstructive sleep apne. Chest 2002;122:829-39
  • Barceló A, Barbé F, LIompart E, et al. Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome: Role of Obesity. Am J Respir Crit Care Med 2004;171:183-7
  • Kapsimalis F, Varouchakis G, Manousaki A, et al. Association of sleep apnea severity and obesity with in- sulin resistance, C-Reactive Protein, and Leptin levels in male patients with obstructive sleep apnea. Lung 2008; 186: 209-17
  • Yki-Järvinen H. Glucose toxicity. Endocrine Reviews 1992; 3:415-31
  • Banno K, Walld R, Kryger MH. Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center. J Clin Sleep Med 2005;3:364-6
  • Tassone F, Lanfranco F, Gianotti L, et al. Obstructive sleep apnoea syndrome impairs insulin sensitivity inde- pendently of anthropometric variables. Clin Endocrinol 2003;59:374-6
  • Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, Smith PL. Sleep-disordered breathing and insulin re- sistance in middle-aged and overweight men. Am J Respir Crit Care Med 2002;165:677-82
  • Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002;165: 670-6
  • Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elavation of cortisol levels the next eve- ning. Sleep 1997;20:865-70
  • Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on matabolic and endocrine function. Lancet 1999;354: 1435-9
  • Hjalmarsen A, Aasebİ U, Birkeland K, Sager G, Jorde R. Impaired glucose tolerance in patients with chronic hipoxic pulmonary disease. Diabetes Metab 1996;22:37-42
  • Rajala R, Partinen M, Sane T, Pelkonen R, Huikuri K. Seppäläinen AM. Obstructive sleep apnoea syndrome in morbidly obese patients. J Intern Med 1991;230:125-9
  • Richman RM, Elliott LM, Burns CM, Bearpark HM, Steinbeck KS, Caterson ID. The prevalence of obstructive sleep apnea in an obese female population. Int J Obes Relat Metab Disord 1994;18:173-7
  • Stoohs RA, Facchini F, Guilleminault C. Insulin resistance and sleep-disordered breathing in healthy humans. Am J Respir Crit Care Med 1996;154:170-4
  • Somers VK, Dyken ME, Clary MP, Abbound FM. Sympathetic neural mechanism in obstructive sleep apnea. J Clin Invest 1995;96:1897-904
  • Sharma SK, Kumpawat S, Coel A, Banga A, Ramakrishnan L, Chaturvedi P. Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleepdisordered breathing. Sleep Med 2008;8:12–7
  • Lara Fernández A, Escolar Castellón JL, Aguilar Cuevas R Fernández Ruiz A, Lara Fernández AL, González Santos P. Obesity and distribution of body fat. Correlation between anthropometric and tomographic data on areas at the ab- dominal level. Rev Clin Esp 1996;196:437-45
  • Jensen MD, Kanaley JA, Reed JE, Sheedy PF. Measurement of abdominal and visceral fat with computed tomogra- phy and dual-energy x-ray absorptiometry. Am J Clin Nutr 1995;61:274-8

Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome

Year 2011, Volume: 8 Issue: 4, 273 - 279, 01.12.2011

Erdem Koçak Gülay Koçak Tacettin Örnek Hatice Bakırtaş Hulusi Atmaca Murat Can Taner Bayraktaroğlu Remzi Altın

Abstract

-

Keywords

-

References

  • Guilleminault C. Clinical features and evaluation of ob- structive sleep apnea, In: Kryger MH, Roth T, Dement WC. (Eds.). Principles and practice of sleep medicine, W.B. Saunders, Philadelphia, 1994
  • Young T, Palta M, Dempsey J, Skatrud J, Weber S., Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-5
  • Peled N, Greenberg A, Pillar G Zinder O, Levi N, Lavie P. Contributions of hypoxia and respiratory disturbance index to sympathetic activation and blood pressure in ob- structive sleep apnea syndrome. Am J Hypertens 1998; 11:1284–9
  • Bjorntorp P. Body fat distribution, insulin resistance, and metabolic diseases. Nutrition 1997;13:795–803
  • Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA 1999;282:1523-9
  • Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med 1993;119:655-60
  • Auwerx J, Staels B. Leptin. Lancet 1998;351:737–42
  • Considine RV, Sinha MK, Heiman ML, et al. Serum immu- noreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292–5
  • Masuzaki H, Ogawa Y, Isse N, et al. Human obese gene expression, Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855–8
  • Masuzaki H, Ogawa Y, Sagawa N, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med 1997;100:1029–33
  • Sobhani I, Bado A, Vissuzaine C, et al. Leptin secretion and leptin receptor in the human stomach. Gut 2000;47: 178–83
  • Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition and menopause on plasma con- centrations of leptin. J Clin Endocrinol Metab 1996;81: 3424-7
  • Ip MS, Lam KS, Ho C, Tsang KW, Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 2000;118:580–6
  • Phillips BG, Kato M, Narkiewiczk K, Choe I, Somers WK. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea. Am J Physiol Heart Circ Physiol 2000;279:H234–7
  • Walder K, Lewandowski P, Morton G, et al. Leptin resis- tance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys Obesus. Int J Obes 1999; 23:83-9
  • Fitzpatrick M. Leptin end the obesity hypoventilation syndrome: A leap of faith? Thorax 2002;57:1–2
  • Zirlik S, Hauck T, Fuchs FS, et al. Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome. Med Sci Monit 2011; 17: CR159-64
  • Tokuda F, Sando Y, Matsui H, Koike H, Yokoyama T. Serum levels of adipocytokines, adiponectin and leptin, in pa- tients with obstructive sleep apnea syndrome. Inter Med 2008;47:1843-9
  • Vgontzas AN, Papanicolaou DA, Bixler EO et al. Sleep ap- nea and daytime sleepiness and fatigue: Relation to vis- ceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 2000;85:1151–8
  • Ozturk L, Unal M, Tamer L, Celikoglu F. The association of the severity of obstructive sleep apnea with plasma leptin levels. Arch Otolaryngol Head Neck Surg 2003;129: 538-40
  • Sanner BM, Kollhosser P, Buechner N, Zidek W, Tepel M. Influence of treatment on leptin levels in patients with obstructive sleep apnea. Eur Respir J 2004;23:601-4
  • Harsch IA, Konturek PC, Koebnick C, et al. Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. Eur Respir J 2003;22:251-7
  • Schafer H, Pauleit D, Sudhop T, Gouni-Berthold I, Ewig S, Berthold HK. Body fat distribution, serum Leptin, and cardiovascular risk factors in men with obstructive sleep apne. Chest 2002;122:829-39
  • Barceló A, Barbé F, LIompart E, et al. Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome: Role of Obesity. Am J Respir Crit Care Med 2004;171:183-7
  • Kapsimalis F, Varouchakis G, Manousaki A, et al. Association of sleep apnea severity and obesity with in- sulin resistance, C-Reactive Protein, and Leptin levels in male patients with obstructive sleep apnea. Lung 2008; 186: 209-17
  • Yki-Järvinen H. Glucose toxicity. Endocrine Reviews 1992; 3:415-31
  • Banno K, Walld R, Kryger MH. Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center. J Clin Sleep Med 2005;3:364-6
  • Tassone F, Lanfranco F, Gianotti L, et al. Obstructive sleep apnoea syndrome impairs insulin sensitivity inde- pendently of anthropometric variables. Clin Endocrinol 2003;59:374-6
  • Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, Smith PL. Sleep-disordered breathing and insulin re- sistance in middle-aged and overweight men. Am J Respir Crit Care Med 2002;165:677-82
  • Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002;165: 670-6
  • Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elavation of cortisol levels the next eve- ning. Sleep 1997;20:865-70
  • Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on matabolic and endocrine function. Lancet 1999;354: 1435-9
  • Hjalmarsen A, Aasebİ U, Birkeland K, Sager G, Jorde R. Impaired glucose tolerance in patients with chronic hipoxic pulmonary disease. Diabetes Metab 1996;22:37-42
  • Rajala R, Partinen M, Sane T, Pelkonen R, Huikuri K. Seppäläinen AM. Obstructive sleep apnoea syndrome in morbidly obese patients. J Intern Med 1991;230:125-9
  • Richman RM, Elliott LM, Burns CM, Bearpark HM, Steinbeck KS, Caterson ID. The prevalence of obstructive sleep apnea in an obese female population. Int J Obes Relat Metab Disord 1994;18:173-7
  • Stoohs RA, Facchini F, Guilleminault C. Insulin resistance and sleep-disordered breathing in healthy humans. Am J Respir Crit Care Med 1996;154:170-4
  • Somers VK, Dyken ME, Clary MP, Abbound FM. Sympathetic neural mechanism in obstructive sleep apnea. J Clin Invest 1995;96:1897-904
  • Sharma SK, Kumpawat S, Coel A, Banga A, Ramakrishnan L, Chaturvedi P. Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleepdisordered breathing. Sleep Med 2008;8:12–7
  • Lara Fernández A, Escolar Castellón JL, Aguilar Cuevas R Fernández Ruiz A, Lara Fernández AL, González Santos P. Obesity and distribution of body fat. Correlation between anthropometric and tomographic data on areas at the ab- dominal level. Rev Clin Esp 1996;196:437-45
  • Jensen MD, Kanaley JA, Reed JE, Sheedy PF. Measurement of abdominal and visceral fat with computed tomogra- phy and dual-energy x-ray absorptiometry. Am J Clin Nutr 1995;61:274-8
There are 40 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Erdem Koçak This is me

Gülay Koçak This is me

Tacettin Örnek This is me

Hatice Bakırtaş This is me

Hulusi Atmaca This is me

Murat Can This is me

Taner Bayraktaroğlu This is me

Remzi Altın This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 8 Issue: 4

Cite

APA Koçak, E., Koçak, G., Örnek, T., Bakırtaş, H., et al. (2011). Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome. European Journal of General Medicine, 8(4), 273-279.
AMA Koçak E, Koçak G, Örnek T, Bakırtaş H, Atmaca H, Can M, Bayraktaroğlu T, Altın R. Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome. European Journal of General Medicine. December 2011;8(4):273-279.
Chicago Koçak, Erdem, Gülay Koçak, Tacettin Örnek, Hatice Bakırtaş, Hulusi Atmaca, Murat Can, Taner Bayraktaroğlu, and Remzi Altın. “Insulin Resistance and Serum Leptin Levels in Men With Obstructive Sleep Apnea Syndrome”. European Journal of General Medicine 8, no. 4 (December 2011): 273-79.
EndNote Koçak E, Koçak G, Örnek T, Bakırtaş H, Atmaca H, Can M, Bayraktaroğlu T, Altın R (December 1, 2011) Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome. European Journal of General Medicine 8 4 273–279.
IEEE E. Koçak, G. Koçak, T. Örnek, H. Bakırtaş, H. Atmaca, M. Can, T. Bayraktaroğlu, and R. Altın, “Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome”, European Journal of General Medicine, vol. 8, no. 4, pp. 273–279, 2011.
ISNAD Koçak, Erdem et al. “Insulin Resistance and Serum Leptin Levels in Men With Obstructive Sleep Apnea Syndrome”. European Journal of General Medicine 8/4 (December 2011), 273-279.
JAMA Koçak E, Koçak G, Örnek T, Bakırtaş H, Atmaca H, Can M, Bayraktaroğlu T, Altın R. Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome. European Journal of General Medicine. 2011;8:273–279.
MLA Koçak, Erdem et al. “Insulin Resistance and Serum Leptin Levels in Men With Obstructive Sleep Apnea Syndrome”. European Journal of General Medicine, vol. 8, no. 4, 2011, pp. 273-9.
Vancouver Koçak E, Koçak G, Örnek T, Bakırtaş H, Atmaca H, Can M, Bayraktaroğlu T, Altın R. Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome. European Journal of General Medicine. 2011;8(4):273-9.