Abstract
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Keywords
References
- Wilkins CE, Emmerson AJ. Extravasation injuries on regional neonatal units. Arch.Dis.Child Fetal Neonatal Ed 2004;F274-F275
- Lynch DJ, Key JC, White RR. Management and prevention of infiltration and extravasation injury. Surg Clin North Am 1979;939-49
- Upton J, Mulliken JB, Murray JE. Major intravenous extravasation injuries. Am J Surg 1979;497-506
- Brown AS, Hoelzer DJ, Piercy SA. Skin necrosis from extravasation of intravenous fluids in children. Plast Reconstr Surg 1979;145-50
- Kumar RJ, Pegg SP, Kimble RM. Management of extravasation injuries. ANZ J Surg 2001;285-9
- Monstrey SJ, Mullick P, Narayanan K, Ramasastry SS. Hyperbaric oxygen therapy and free radical production: an experimental study in doxorubicin (Adriamycin) extravasation injuries. Ann Plast Surg 1997;163-8
- Sommer NZ, Bayati S, Neumeister M, Brown RE. Dapsone for the treatment of doxorubicin extravasation injury in the rat. Plast Reconstr Surg 2002;2000-5
- Tiras U, Erdeve O, Karabulut AA, Dallar Y, Eksioglu HM. Debridement via collagenase application in two neonates. Pediatr Dermatol 2005;472-5 Aydınöz et al.
Abstract
Aim: Parenteral alimentation fluids containing calcium are widely used to treat sick neonates and children. Extravasation of calcium presents with local swelling, erythema, blistering and progresses to skin necrosis and skin loss. Several treatment modalities including hyperbaric oxygen therapy have been used for extravasation injuries. The role of hyperbaric oxygen therapy on extravasation injuries was investigated in this study by an experimental rat model based on facilitating effect of hyperbaric oxygen on wound healing. Methods: After shaving the dorsal side of 16 female Wistar rats, 1 ml of calcium chloride were injected intradermally. The rats were divided into two groups as control and hyperbaric oxygen. The control group received no treatment while the hyperbaric oxygen group received hyperbaric oxygen therapy for 7 days after injection. At the end of seventh day skin biopsy including all necrotic tissue and surrounding healthy tissue were obtained and histopathologic examination was performed for control and hyperbaric oxygen groups. Results: Hyperbaric oxygen group showed a statistically significant preservation of epidermis and dermis with minimal necrosing findings of skin injury. Conclusion: Although further research is required to develop management guidelines, we concluded that in this experimental study, hyperbaric oxygen therapy prevents dermal injury and may decrease the morbidity associated with calcium chloride extravasation injury
Keywords
References
- Wilkins CE, Emmerson AJ. Extravasation injuries on regional neonatal units. Arch.Dis.Child Fetal Neonatal Ed 2004;F274-F275
- Lynch DJ, Key JC, White RR. Management and prevention of infiltration and extravasation injury. Surg Clin North Am 1979;939-49
- Upton J, Mulliken JB, Murray JE. Major intravenous extravasation injuries. Am J Surg 1979;497-506
- Brown AS, Hoelzer DJ, Piercy SA. Skin necrosis from extravasation of intravenous fluids in children. Plast Reconstr Surg 1979;145-50
- Kumar RJ, Pegg SP, Kimble RM. Management of extravasation injuries. ANZ J Surg 2001;285-9
- Monstrey SJ, Mullick P, Narayanan K, Ramasastry SS. Hyperbaric oxygen therapy and free radical production: an experimental study in doxorubicin (Adriamycin) extravasation injuries. Ann Plast Surg 1997;163-8
- Sommer NZ, Bayati S, Neumeister M, Brown RE. Dapsone for the treatment of doxorubicin extravasation injury in the rat. Plast Reconstr Surg 2002;2000-5
- Tiras U, Erdeve O, Karabulut AA, Dallar Y, Eksioglu HM. Debridement via collagenase application in two neonates. Pediatr Dermatol 2005;472-5 Aydınöz et al.
Details
| Primary Language | English |
|---|---|
| Journal Section | Original Articles |
| Publication Date | December 1, 2007 |
| Published in Issue | Year 2007 Volume: 4 Issue: 4 |