THE RELATIONSHIP BETWEEN OXIDATIVE STRESS, NITRIC OXIDE, AND CORONARY ARTERY DISEASE

Year 2007, Volume: 4 Issue: 2, 62 - 66, 01.06.2007

Serdar Soydinç Ahmet Çelik Seniz Demiryürek Vedat Davutoğlu Mehmet Tarakçıoğlu Mehmet Aksoy

Abstract

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Keywords

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THE RELATIONSHIP BETWEEN OXIDATIVE STRESS, NITRIC OXIDE, AND CORONARY ARTERY DISEASE

Abstract

Aim: Oxidative stress and free radicals are known to have important roles in the development of atherosclerosis. Malondialdehyde (MDA), a carbonile group produced during lipid peroxidation, is used widely in determining oxidative stress. Nitric Oxide (NO) is a vasodilatator agent derived from the endothelium. The aim of our study was to investigate the relationship between MDA and NO in patient with coronary artery disease. Methods: Forty-five patients diagnosed with 50 % or more stenosis by coronary angiography were included in our study. Patients were separated as 1, 2 and 3 vessel-patients according to the number of vessels affected. Diabetics, smoking patients, patients with malignancy, renal and liver disease, and patients using nitrate preparation were excluded from the study. Fortyfive healthy individuals, who had cardiological evaluation in the last year were identified as the control group. MDA, NO, and lipid measurements were performed accordingly. Results: Serum MDA levels were significantly higher in the CAD group when compared to the controls (p0.05). No significant differences were observed in the comparison of NO levels between one, two and three vessel patients. NO levels were significantly higher in hypertensive CAD patients than the normotensive ones (p

Keywords

Coronary artery disease, malondialdehyde, nitric oxide, oxidative stress

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