THE EFFECTS OF ALCOHOL EXPOSURE DURING INTRAUTERINE AND POSTNATAL PERIOD ON BONE MINERAL DENSITY AND BONE GROWTH AND BODY WEIGHT IN RATS' VIRGIN OFFSPRING
Abstract
-
Keywords
References
- Jones KL, Smith DW. The fetal alcohol syndrome. Teratology 1975;12(1):1-10
- Day NL, Leech SL, Richardson GA et al. Prenatal alcohol exposure predicts continued deficits in offspring size at 14 years of age. Alcohol Clin Exp Res 2002;26(10):1584-91
- Keiver K, Herbert L, Weinberg J. Effect of maternal ethanol consumption on maternal and fetal calcium metabolism. Alcohol Clin Exp Res 1996;20(7):1305- 12
- Schnitzler CM, Solomon L. Bone changes after alcohol abuse. S Afr Med J 1984;66(19):730-4
- Diamond T, Stiel D, Lunzer M et al. Ethanol reduces bone formation and may cause osteoporosis. Am J Med 1989;86(3):282-8
- Gonzalez-Calvin JL, Garcia-Sanchez A, Bellot V et al. Mineral metabolism, osteoblastic function and bone mass in chronic alcoholism. Alcohol 1993;28(5): 571-9
- Turner RT. Skeletal response to alcohol. Alcohol Clin Exp Res 2000;24(11):1693- 701
- Maran A, Zhang M, Spelsberg TC et al. The dose-response effects of ethanol on the human fetal osteoblastic cell line. J Bone Miner Res 2001;16(2):270-6
- Dai J, Lin D, Zhang J et al. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J Clin Invest 2000;106(7):887-95
- Yao Z, Zhang J, Dai J et al. Ethanol activates NFkappaB DNA binding and p56lck protein tyrosine kinase in human osteoblast-like cells. Bone 2001;28(2): 167-73
- Morii H, Genant HK. Statement on the diagnosis and management of osteoporosis from the Consensus Development Conference at the Second International Conference on Osteoporosis, Osaka 1997. J Bone Miner Metab 1998;16:206-14
- Wolf RL, Wehrli SL, Popescu AM et al. Mineral volume and morphology in carotid plaque specimens using high- resolution MRI and CT. Arterioscler Thromb Vasc Biol. 2005;25(8):1729-35
- Jarvinen M, Kannus P, Tampere F. Injury of an extremity as a risk factor for the development of osteoporosis. J Bone Joint Surg 1997;79-A:263-76
- Uzbay IT, Kayaalp SO. A modified liquid diet of chronic ethanol administration: validation syndrome in rats. Pharmacol Res 1995;31(1):37-42 withdrawal
- Murphy E, Bresnihan B, FitzGerald O. Validated measurement of periarticular bone mineral density at the knee joint by dual energy x ray absorptiometry. Ann Rheum Dis. 2001;60(1):8-13
- Santolaria F, Gonzalez-Reimers E, Perez- Manzano JL, et al. Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients. Alcohol 2000;22(3):147-57
- Norton S, Kotkoskie LA. Basic animal research. Recent Dev Alcohol 1991;9:95- 115
- Keiver K, Herbert L, Weinberg J. Effect of maternal ethanol consumption on maternal and fetal calcium metabolism. Alcohol Clin Exp Res 1996;20(7):1305- 12
- Keiver K, Ellis L, Anzarut A et al. Effect of prenatal ethanol exposure on fetal calcium metabolism. Alcohol Clin Exp Res 1997;21(9):1612-8
- Murillo-Fuentes L, Artillo R, Carreras O et al. Effects of maternal chronic alcohol administration in the rat: lactation performance and pup’s growth. Eur J Nutr 2001;40(4):147-54
THE EFFECTS OF ALCOHOL EXPOSURE DURING INTRAUTERINE AND POSTNATAL PERIOD ON BONE MINERAL DENSITY AND BONE GROWTH AND BODY WEIGHT IN RATS' VIRGIN OFFSPRING
Abstract
Aim: To investigate the effects of alcohol contained continuous modified liquid diet ingestion in rats\' offspring on bone length, bone mineral density and body weights. Methods: In Alcoholic group (n= 19), Wistar rats\' offspring were provided 7.2% ethanol during intrauterine and postnatal breast feeding period (4 weeks). These rats were fed by modified liquid diet without ethanol till 12 weeks of age after weaning. Control group (pair-fed control rats, n= 9) was fed an isocaloric Modified Liquid Diet without ethanol throughout the experiment (12 weeks). In the all rats, bone mineral density (BMD) of the bilateral tibias were measured with dual-energy X-ray absorptiometry (DEXA) and statistically compared. Results: Compared with control group, there was a significant fall in tibia length (p=0.02); but the mild loss of body weight and bone mineral density was not found statistically significant (p>0.05). Conclusion: Mild decrease in bone loss and body weights in offspring rats of provided alcohol during intrauterine life may be attributed the irregular feeding habits due to social factors in chronic alcohol consumption in human. Our findings related the significant short tibia length in chronic alcohol treated rats during pregnancy and lactation period were found correlated with the studies in human and animal models. Key words: Alcoholism, Intrauterine growth retardation, Bone mineral density.
References
- Jones KL, Smith DW. The fetal alcohol syndrome. Teratology 1975;12(1):1-10
- Day NL, Leech SL, Richardson GA et al. Prenatal alcohol exposure predicts continued deficits in offspring size at 14 years of age. Alcohol Clin Exp Res 2002;26(10):1584-91
- Keiver K, Herbert L, Weinberg J. Effect of maternal ethanol consumption on maternal and fetal calcium metabolism. Alcohol Clin Exp Res 1996;20(7):1305- 12
- Schnitzler CM, Solomon L. Bone changes after alcohol abuse. S Afr Med J 1984;66(19):730-4
- Diamond T, Stiel D, Lunzer M et al. Ethanol reduces bone formation and may cause osteoporosis. Am J Med 1989;86(3):282-8
- Gonzalez-Calvin JL, Garcia-Sanchez A, Bellot V et al. Mineral metabolism, osteoblastic function and bone mass in chronic alcoholism. Alcohol 1993;28(5): 571-9
- Turner RT. Skeletal response to alcohol. Alcohol Clin Exp Res 2000;24(11):1693- 701
- Maran A, Zhang M, Spelsberg TC et al. The dose-response effects of ethanol on the human fetal osteoblastic cell line. J Bone Miner Res 2001;16(2):270-6
- Dai J, Lin D, Zhang J et al. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J Clin Invest 2000;106(7):887-95
- Yao Z, Zhang J, Dai J et al. Ethanol activates NFkappaB DNA binding and p56lck protein tyrosine kinase in human osteoblast-like cells. Bone 2001;28(2): 167-73
- Morii H, Genant HK. Statement on the diagnosis and management of osteoporosis from the Consensus Development Conference at the Second International Conference on Osteoporosis, Osaka 1997. J Bone Miner Metab 1998;16:206-14
- Wolf RL, Wehrli SL, Popescu AM et al. Mineral volume and morphology in carotid plaque specimens using high- resolution MRI and CT. Arterioscler Thromb Vasc Biol. 2005;25(8):1729-35
- Jarvinen M, Kannus P, Tampere F. Injury of an extremity as a risk factor for the development of osteoporosis. J Bone Joint Surg 1997;79-A:263-76
- Uzbay IT, Kayaalp SO. A modified liquid diet of chronic ethanol administration: validation syndrome in rats. Pharmacol Res 1995;31(1):37-42 withdrawal
- Murphy E, Bresnihan B, FitzGerald O. Validated measurement of periarticular bone mineral density at the knee joint by dual energy x ray absorptiometry. Ann Rheum Dis. 2001;60(1):8-13
- Santolaria F, Gonzalez-Reimers E, Perez- Manzano JL, et al. Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients. Alcohol 2000;22(3):147-57
- Norton S, Kotkoskie LA. Basic animal research. Recent Dev Alcohol 1991;9:95- 115
- Keiver K, Herbert L, Weinberg J. Effect of maternal ethanol consumption on maternal and fetal calcium metabolism. Alcohol Clin Exp Res 1996;20(7):1305- 12
- Keiver K, Ellis L, Anzarut A et al. Effect of prenatal ethanol exposure on fetal calcium metabolism. Alcohol Clin Exp Res 1997;21(9):1612-8
- Murillo-Fuentes L, Artillo R, Carreras O et al. Effects of maternal chronic alcohol administration in the rat: lactation performance and pup’s growth. Eur J Nutr 2001;40(4):147-54
There are 20 citations in total.
Details
| Primary Language | English |
|---|---|
| Journal Section | Original Articles |
| Authors | |
| Publication Date | June 1, 2006 |
| Published in Issue | Year 2006 Volume: 3 Issue: 2 |