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EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)

Year 2005, Volume: 2 Issue: 3, 100 - 109, 01.09.2005

Zuhal Altunkaynak

Abstract

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Keywords

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References

  • Akiyama T, Tachibana I, Shirohara H et al. High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diabetes Res and Clin Pract 1996;1:27-35
  • Abu-Abid S, Szold A, Klausner J. Obesity and cancer. J Med. 2002;33(1-4):73-86
  • Pi-Sunyer FX. The medical risks of obesity. Obes Surg 2002;12:6-11
  • Ramos EJ, Xu Y, Romanova I. Is obesity an inflamatuar disease? Surgery 2003; 134(2):329-35
  • Bailhache E, Ouguerram K, Gayet C. et al. An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique. J Anim Physiol Anim Nutr 2003;87(3-4):86-95
  • Arner P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones.Trends Endocrinol Metab 2003;14(3):137-45
  • Bugianesi E, Manzini P, D’Antico S. et al. Relative contribution of iron burden, HFE mutations and insulin resistance to fibrosis in non alcoholic fatty liver. Hepatology 2004;39:179-87
  • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346(16):1221-31
  • Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003;98(5): 960-7
  • Ioannou GN, Weiss NS, Kowdley KV, Dominitz JA. Is obesity a risk factor for cirrhosis-related death or hospitalization? A Gastroenterol 2003;125:1053–9 cohort study.
  • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625–38
  • Lam GM, Mobarhan S. Central obesity and elevated liver enzymes. Nutr Rev 2004;62(10):394-9
  • Nasrallah SM, Wills CEJ, Galambos JT. Hepatic morphology in obesity. Digestive Diseases and Sciences 1981;26:325-7
  • Braillon A, Capron JP, Herve MA et al. Liver in Obesity. Gut 1985;26:776-83
  • Wael IY, Arthur JM. Steatohepatitis in obese individuals. Best Pract Res Clin Gastroenterol 2002;16(5):733-47
  • Day P, James OF. Steatohepatitis: a tale of two hits? Gastroenterol 1998;114:842-5
  • Caldwell SH, Oelsner DH, Lezzoni JC, Hespenheide EE, Bantle EH., Driscoll CJ. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999; 29: 664-9
  • Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. Hepatol 2005;42(1):132-8
  • Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94(9): 2467-74
  • Altunkaynak BZ, Özbek E. Histological assesment of obesity induced NAFLD in female obese rats. 17th National Electron Microscopy Congress, 26-30 June 2005;Gebze- Turkey.
  • Harris RB. Factors influencing energy intake of rats fed either a high-fat or a fat mimetic diet. Int J Obes Metab Disord 1994;18:632-640
  • Bellinger LL, Bernardis LL. Effect of dorsomedial hypothalamic nuclei knife cuts on ingestive behavior. Am J Physiol 1999;276:1772-9
  • Kiernan AJ. Theory and practice In: Histological and Histochemical Methods. Oxford: Pergamon Press, 2003:35-6
  • Roden M, Anderwald C, Furnsinn C, Waldhausl W, Lohninger A. Effects of short-term leptin exposure on triglyceride deposition in rat liver. Hepatology 2000; 32(5):1045-9
  • Lieber CS, Leo MA, Mak KM et al. Model of nonalcoholic steatohepatitis. Am J Clin Nutr 2004;79(3):502-9
  • Brent A, Neuschwander-Tetri BA, Caldwell SH. Summary of an AASLD Single Topic Conference Hepatology 2003;37(5):1202- 19 steatohepatitis:
  • Gaiva MH, Couto RC, Oyama LM et al. Diets rich in polyunsaturated fatty acids: effect on hepatic metabolism in rats. Nutrition 2003;19(2):144-9
  • Abraham P, Wilfred G, Ramakrishna B. Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat. Clin Chim Acta 2002;325(1-2): 117-25
  • Koteish A, Mae Diehl A. Animal models of steatohepatitis.Best Pract Res Clin Gastroenterol 2002 Oct;16(5):679-90
  • Te Sligte K, Bourass I, Sels JP et al. Non-alcoholic steatohepatitis: review of a growing medical problem. Eur J Intern Med 2004;15(1):10-21
  • Denk H, Stumptner C, Fuchsbichler A, Zatloukal K. Alcoholic and nonalcoholic steatohepatitis. pathogenetic considerations Pathologe 2001;22(6):388-98 and
  • MacDonald GA, Bridle KR, Ward PJ. et al. Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3. J Gastroenterol Hepatol 2001;16(6): 599-606
  • Duvnjak M, Virovic L. Non-alcoholic steatohepatitis. Acta Med Croatica 2003; 57 (3):189-99

EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)

Year 2005, Volume: 2 Issue: 3, 100 - 109, 01.09.2005

Zuhal Altunkaynak

Abstract

Aim: Obesity is an important, complex and chronic disease. Fatty diet is a significant factor causing obesity. It is known that obesity is associated with many chronic disorders such as NonAlcoholic Fatty Liver Disease (NAFLD). However, mechanism of this event is yet unclear. In this study, it was purposed to examine histological effects of fatty diet induced obesity on liver from female obese rats. Methods: Within scope of this aim, the obesity model was performed on animals of the study group, (Sprague Dawley rats), by feeding them with a diet comprised highly of fat, for a duration of 2-3 months. After this controlled nutritional process, livers were removed from all sacrificed rats and viewed under light microscope. Results: In study groups\' slides; mononuclear cell infiltrations, foci of necrosis, vascular dilatation, an increase in hepatic connective tissue, hepatocellular steatosis and shrinkage, additional cytoplasmic acidophily and nuclear density in the hepatocytes were determined. Finally, it was observed that fat-rich diet (%30) had caused a liver damage. Conclusion: We think that our light microscopical finding would contribute clarifying the histopathological mechanism of obesity. Key words: Liver, Light microscopy, Fatty diet, Obesity.

Keywords

Liver Light microscopy Fatty diet Obesity

References

  • Akiyama T, Tachibana I, Shirohara H et al. High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diabetes Res and Clin Pract 1996;1:27-35
  • Abu-Abid S, Szold A, Klausner J. Obesity and cancer. J Med. 2002;33(1-4):73-86
  • Pi-Sunyer FX. The medical risks of obesity. Obes Surg 2002;12:6-11
  • Ramos EJ, Xu Y, Romanova I. Is obesity an inflamatuar disease? Surgery 2003; 134(2):329-35
  • Bailhache E, Ouguerram K, Gayet C. et al. An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique. J Anim Physiol Anim Nutr 2003;87(3-4):86-95
  • Arner P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones.Trends Endocrinol Metab 2003;14(3):137-45
  • Bugianesi E, Manzini P, D’Antico S. et al. Relative contribution of iron burden, HFE mutations and insulin resistance to fibrosis in non alcoholic fatty liver. Hepatology 2004;39:179-87
  • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346(16):1221-31
  • Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003;98(5): 960-7
  • Ioannou GN, Weiss NS, Kowdley KV, Dominitz JA. Is obesity a risk factor for cirrhosis-related death or hospitalization? A Gastroenterol 2003;125:1053–9 cohort study.
  • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625–38
  • Lam GM, Mobarhan S. Central obesity and elevated liver enzymes. Nutr Rev 2004;62(10):394-9
  • Nasrallah SM, Wills CEJ, Galambos JT. Hepatic morphology in obesity. Digestive Diseases and Sciences 1981;26:325-7
  • Braillon A, Capron JP, Herve MA et al. Liver in Obesity. Gut 1985;26:776-83
  • Wael IY, Arthur JM. Steatohepatitis in obese individuals. Best Pract Res Clin Gastroenterol 2002;16(5):733-47
  • Day P, James OF. Steatohepatitis: a tale of two hits? Gastroenterol 1998;114:842-5
  • Caldwell SH, Oelsner DH, Lezzoni JC, Hespenheide EE, Bantle EH., Driscoll CJ. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999; 29: 664-9
  • Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. Hepatol 2005;42(1):132-8
  • Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94(9): 2467-74
  • Altunkaynak BZ, Özbek E. Histological assesment of obesity induced NAFLD in female obese rats. 17th National Electron Microscopy Congress, 26-30 June 2005;Gebze- Turkey.
  • Harris RB. Factors influencing energy intake of rats fed either a high-fat or a fat mimetic diet. Int J Obes Metab Disord 1994;18:632-640
  • Bellinger LL, Bernardis LL. Effect of dorsomedial hypothalamic nuclei knife cuts on ingestive behavior. Am J Physiol 1999;276:1772-9
  • Kiernan AJ. Theory and practice In: Histological and Histochemical Methods. Oxford: Pergamon Press, 2003:35-6
  • Roden M, Anderwald C, Furnsinn C, Waldhausl W, Lohninger A. Effects of short-term leptin exposure on triglyceride deposition in rat liver. Hepatology 2000; 32(5):1045-9
  • Lieber CS, Leo MA, Mak KM et al. Model of nonalcoholic steatohepatitis. Am J Clin Nutr 2004;79(3):502-9
  • Brent A, Neuschwander-Tetri BA, Caldwell SH. Summary of an AASLD Single Topic Conference Hepatology 2003;37(5):1202- 19 steatohepatitis:
  • Gaiva MH, Couto RC, Oyama LM et al. Diets rich in polyunsaturated fatty acids: effect on hepatic metabolism in rats. Nutrition 2003;19(2):144-9
  • Abraham P, Wilfred G, Ramakrishna B. Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat. Clin Chim Acta 2002;325(1-2): 117-25
  • Koteish A, Mae Diehl A. Animal models of steatohepatitis.Best Pract Res Clin Gastroenterol 2002 Oct;16(5):679-90
  • Te Sligte K, Bourass I, Sels JP et al. Non-alcoholic steatohepatitis: review of a growing medical problem. Eur J Intern Med 2004;15(1):10-21
  • Denk H, Stumptner C, Fuchsbichler A, Zatloukal K. Alcoholic and nonalcoholic steatohepatitis. pathogenetic considerations Pathologe 2001;22(6):388-98 and
  • MacDonald GA, Bridle KR, Ward PJ. et al. Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3. J Gastroenterol Hepatol 2001;16(6): 599-606
  • Duvnjak M, Virovic L. Non-alcoholic steatohepatitis. Acta Med Croatica 2003; 57 (3):189-99
There are 33 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Zuhal Altunkaynak This is me

Publication Date September 1, 2005
Published in Issue Year 2005 Volume: 2 Issue: 3

Cite

APA Altunkaynak, Z. (2005). EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY). European Journal of General Medicine, 2(3), 100-109.
AMA Altunkaynak Z. EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY). European Journal of General Medicine. September 2005;2(3):100-109.
Chicago Altunkaynak, Zuhal. “EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)”. European Journal of General Medicine 2, no. 3 (September 2005): 100-109.
EndNote Altunkaynak Z (September 1, 2005) EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY). European Journal of General Medicine 2 3 100–109.
IEEE Z. Altunkaynak, “EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)”, European Journal of General Medicine, vol. 2, no. 3, pp. 100–109, 2005.
ISNAD Altunkaynak, Zuhal. “EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)”. European Journal of General Medicine 2/3 (September 2005), 100-109.
JAMA Altunkaynak Z. EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY). European Journal of General Medicine. 2005;2:100–109.
MLA Altunkaynak, Zuhal. “EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)”. European Journal of General Medicine, vol. 2, no. 3, 2005, pp. 100-9.
Vancouver Altunkaynak Z. EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY). European Journal of General Medicine. 2005;2(3):100-9.