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HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER

Year 2005, Volume: 2 Issue: 2, 56 - 61, 01.06.2005

Abstract

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References

  • Breteler MMB, van Swieten JC, Bots ML et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994;44: 1246-52
  • Yamanishi T. Urinary function in elderly
  • people with and without leukoaraiosis:
  • relation to cognitive and gait function. J Neurol Neurosurg Psychiatry 1999;67: 658-60
  • Inzitari D.Leukoaraiosis: an independent risk factor for stroke?Stroke 2003;34: 2067-71
  • Vermeer SE, Hollander M, van Dijk EJ et al. Rotterdam Scan Study.Silent brain infarcts and white matter lesions increase stroke risk in the general population : the Rotterdam Scan Study. Stroke 2003;34: 1126-9
  • Wiszniewska M, Devuyst G, Bogousslavsky J, Ghika J, van Melle G. What is the significance of leukoaraiosis in patients with acute ischemic stroke? Arch Neurol 2000;57(7):967-73
  • Meyer JS, Rauch GM, Rauch RA, Haque A, Crawford K. Cardiovascular and other risk factors for Alzheimer’s disease and vascular dementia. Ann NY Acad Sci 2000;903:411-23
  • Yamauchi H, Fukuda H, Oyanagi C. Significance of white matter high intensity lesions as a predictor of stroke from arteriolosclerosis. J Neurol Neurosurg Psychiatry 2002 ;72:576-82
  • Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Leukoaraiosis in stroke patients. The Copenhagen Stroke Study. Stroke 1995;26:588-92
  • Streifler JY, Eliasziw M, Benavente OR et al. North American Symptomatic Carotid Endarterectomy Trial Group. Development and progression of leukoaraiosis in patients with brain ischemia and carotid artery disease. Stroke 2003;34:1913-6
  • Kohara K, Zhao B, Jiang Y et al. Relation of left ventricular hypertrophy and geometry to asymptomatic cerebro-vascular damage in essential hypertension. Am J Cardiol 1999;83:367-70
  • Gorter JW. Stroke Prevention In Reversible Ischemic Trial (SPIRIT) and European Atrial Fibrillation Trial (EAFT) study groups. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Neurology 1999 ;53:1319-27
  • Lip GY, Beevers DC, Singh SF, Watson RD. ABC of atrial fibrillation. Aetiology, pathophysiology, and clinical features. BMJ 1995;311:1425-28
  • Meyer JS, Terayama Y, Konno S, Akiyama H, Margishvili GM, Mortel KF. Risk factors for cerebral degenerative changes and dementia. Eur Neurol 1998;39(Suppl)1:7-16
  • Tarvonen-Schroder S, Roytta M, Raiha I, Kurki T, Rajala T, Sourander L.Clinical features of leuko-araiosis. J Neurol Neurosurg Psychiatry 1996;60:431-6
  • Tarvonen-Schroder S, Kurki T, Raiha I, Sourander L.Leukoaraiosis and cause of death: a five year follow up. J Neurol Neurosurg Psychiatry 1995;58:586-9

HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER

Year 2005, Volume: 2 Issue: 2, 56 - 61, 01.06.2005

Abstract

Aim: Diminished cardiac output can lead to the development of white matter lesions. White matter lesions are related to cognitive impairment, stroke risk and vascular death, yet the precise aetiology is uncertain. Methods: In this study we recruited 130 patients attending our medicine and neurology outpatient department, and divided them into those with a history of heart failure (n:24), atrial fibrillation (n:26), and those with atherosclerotic risk factors (n:80). The patients without low output heart failure and atrial fibrillation were grouped as control. We studied the magnetic resonance imaging (MRI) findings associated with low cardiac output and adjusted for confounding factors. Heart failure with low cardiac output was diagnosed by a cardiologist. Results: The presence of leukoaraiosis (LA) on MRI was assessed in 80 patients with modifiable atherosclerotic risk factors (control group) and 50 patients having heart failure or atrial fibrillation. Hyperintense lesions in T2 and proton weighted and non-hypotense lesions in T1 weighted sequences were considered as white matter abnormalities. MRIs of all cases were evaluated by means of a four grade scoring system -described previously in the literature- by the same neurologist. White matter lesions of patients with heart failure, atrial fibrillation or atherosclerotic risk factors were compared. Patients in the study group were divided into two groups according to the presence of heart failure due to etiologies other than atrial fibrillation (n:24) and atrial fibrillation (n:26). Leukoaraiosis was observed in 18 (75%) cases with heart failure, 18 (69.2%) cases with atrial fibrillation, and 61 (76.3%) patients in the control group. There was no difference between the three groups with respect to the presence of LA (x2:0.51, p: 0.77). Conclusion: This study demonstrated that there was no significant association between heart failure and white matter abnormalities independent of other risk factors despite the fact that cardiac disorders apparently manifested themselves as cases with severe leukoaraiosis. Key words: White matter, leukoaraiosis, risk factors, cardiac failure, atrial fibrilation

References

  • Breteler MMB, van Swieten JC, Bots ML et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994;44: 1246-52
  • Yamanishi T. Urinary function in elderly
  • people with and without leukoaraiosis:
  • relation to cognitive and gait function. J Neurol Neurosurg Psychiatry 1999;67: 658-60
  • Inzitari D.Leukoaraiosis: an independent risk factor for stroke?Stroke 2003;34: 2067-71
  • Vermeer SE, Hollander M, van Dijk EJ et al. Rotterdam Scan Study.Silent brain infarcts and white matter lesions increase stroke risk in the general population : the Rotterdam Scan Study. Stroke 2003;34: 1126-9
  • Wiszniewska M, Devuyst G, Bogousslavsky J, Ghika J, van Melle G. What is the significance of leukoaraiosis in patients with acute ischemic stroke? Arch Neurol 2000;57(7):967-73
  • Meyer JS, Rauch GM, Rauch RA, Haque A, Crawford K. Cardiovascular and other risk factors for Alzheimer’s disease and vascular dementia. Ann NY Acad Sci 2000;903:411-23
  • Yamauchi H, Fukuda H, Oyanagi C. Significance of white matter high intensity lesions as a predictor of stroke from arteriolosclerosis. J Neurol Neurosurg Psychiatry 2002 ;72:576-82
  • Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Leukoaraiosis in stroke patients. The Copenhagen Stroke Study. Stroke 1995;26:588-92
  • Streifler JY, Eliasziw M, Benavente OR et al. North American Symptomatic Carotid Endarterectomy Trial Group. Development and progression of leukoaraiosis in patients with brain ischemia and carotid artery disease. Stroke 2003;34:1913-6
  • Kohara K, Zhao B, Jiang Y et al. Relation of left ventricular hypertrophy and geometry to asymptomatic cerebro-vascular damage in essential hypertension. Am J Cardiol 1999;83:367-70
  • Gorter JW. Stroke Prevention In Reversible Ischemic Trial (SPIRIT) and European Atrial Fibrillation Trial (EAFT) study groups. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Neurology 1999 ;53:1319-27
  • Lip GY, Beevers DC, Singh SF, Watson RD. ABC of atrial fibrillation. Aetiology, pathophysiology, and clinical features. BMJ 1995;311:1425-28
  • Meyer JS, Terayama Y, Konno S, Akiyama H, Margishvili GM, Mortel KF. Risk factors for cerebral degenerative changes and dementia. Eur Neurol 1998;39(Suppl)1:7-16
  • Tarvonen-Schroder S, Roytta M, Raiha I, Kurki T, Rajala T, Sourander L.Clinical features of leuko-araiosis. J Neurol Neurosurg Psychiatry 1996;60:431-6
  • Tarvonen-Schroder S, Kurki T, Raiha I, Sourander L.Leukoaraiosis and cause of death: a five year follow up. J Neurol Neurosurg Psychiatry 1995;58:586-9
There are 17 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Abdulkadir Koçer This is me

Özlem Esen This is me

Nurhan İnce This is me

Eren Gözke This is me

Osman Karakaya This is me

İrfan Barutçu This is me

Publication Date June 1, 2005
Published in Issue Year 2005 Volume: 2 Issue: 2

Cite

APA Koçer, A., Esen, Ö., İnce, N., Gözke, E., et al. (2005). HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER. European Journal of General Medicine, 2(2), 56-61.
AMA Koçer A, Esen Ö, İnce N, Gözke E, Karakaya O, Barutçu İ. HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER. European Journal of General Medicine. June 2005;2(2):56-61.
Chicago Koçer, Abdulkadir, Özlem Esen, Nurhan İnce, Eren Gözke, Osman Karakaya, and İrfan Barutçu. “HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER”. European Journal of General Medicine 2, no. 2 (June 2005): 56-61.
EndNote Koçer A, Esen Ö, İnce N, Gözke E, Karakaya O, Barutçu İ (June 1, 2005) HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER. European Journal of General Medicine 2 2 56–61.
IEEE A. Koçer, Ö. Esen, N. İnce, E. Gözke, O. Karakaya, and İ. Barutçu, “HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER”, European Journal of General Medicine, vol. 2, no. 2, pp. 56–61, 2005.
ISNAD Koçer, Abdulkadir et al. “HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER”. European Journal of General Medicine 2/2 (June 2005), 56-61.
JAMA Koçer A, Esen Ö, İnce N, Gözke E, Karakaya O, Barutçu İ. HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER. European Journal of General Medicine. 2005;2:56–61.
MLA Koçer, Abdulkadir et al. “HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER”. European Journal of General Medicine, vol. 2, no. 2, 2005, pp. 56-61.
Vancouver Koçer A, Esen Ö, İnce N, Gözke E, Karakaya O, Barutçu İ. HEART FAILURE WITH LOW CARDIAC OUTPUT AND RISK OF DEVELOPMENT OF LESIONS IN THE CEREBRAL WHITE MATTER. European Journal of General Medicine. 2005;2(2):56-61.