Genotype distribution of hepatitis C virus in Bolu province

Mustafa Behçet; Ayça Çisem Harre; Fatma Avcıoğlu; Hakan Burak Çelik; Elif Soysal; Yusuf Afşar; Muhammet Güzel Kurtoğlu

doi:10.55971/EJLS.1882801

Genotype distribution of hepatitis C virus in Bolu province

Abstract

Viral genotypes play a critical role in the clinical course and treatment planning of chronic liver disease caused by the hepatitis C virus (HCV). This study aimed to investigate the distribution of HCV genotypes and subtypes in patients from Bolu, thereby contributing to the understanding of HCV molecular epidemiology and supporting the development of treatment strategies. The HCV genotyping results of blood samples obtained from HCV RNA-positive patients and submitted to the Medical Microbiology Laboratory between 2017 and 2024 were retrospectively analyzed. HCV genotype determination was performed using a real-time polymerase chain reaction method. A total of 65 patients were included in the study, of whom 55.4% were female and 44.6% were male, with a mean age of 61.1 years (range: 25–96). The most frequently detected HCV genotype was 1b (69.2%), followed by 1a and 3 (13.8%), while 4 was detected in 3.1% of cases; genotype 2 was not observed. A significant association was found between gender and HCV genotype distribution, with genotype 1b being more prevalent in women and genotype 3 being more frequent in men. When evaluated according to age groups, the average age of patients with genotype 1b (67.6±14.6) was found to be higher than that of patients with genotype 3 (42.1±10.9). To our knowledge, this study is the first to report the distribution of HCV genotypes in Bolu province and supports the finding that genotype 1b is the dominant type. These findings may contribute to the development of treatment strategies and provide regional epidemiological data.

Keywords

References

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Details

Primary Language

English

Subjects

Virology

Journal Section

Research Article

Authors

Mustafa Behçet ^*
0000-0002-5676-6983
Türkiye

Ayça Çisem Harre
0009-0001-7708-8974
Türkiye

Fatma Avcıoğlu
0000-0002-6011-7775
Türkiye

Hakan Burak Çelik
0009-0008-9145-7191
Türkiye

Elif Soysal
0009-0007-4752-680X
Türkiye

Yusuf Afşar
0000-0003-3316-3618
Türkiye

Muhammet Güzel Kurtoğlu
0000-0002-7057-2501
Türkiye

Publication Date

August 31, 2026

Submission Date

February 6, 2026

Acceptance Date

May 3, 2026

Published in Issue

Year 2026 Volume: 5 Number: 2

DOI

https://doi.org/10.55971/EJLS.1882801

IZ

https://izlik.org/JA95NM49WK

Cite

RIS / Bibtex

APA

Behçet, M., Harre, A. Ç., Avcıoğlu, F., Çelik, H. B., Soysal, E., Afşar, Y., & Kurtoğlu, M. G. (2026). Genotype distribution of hepatitis C virus in Bolu province. European Journal of Life Sciences, 5(2), 89-95. https://doi.org/10.55971/EJLS.1882801

AMA

1.Behçet M, Harre AÇ, Avcıoğlu F, et al. Genotype distribution of hepatitis C virus in Bolu province. Eur J Life Sci. 2026;5(2):89-95. doi:10.55971/EJLS.1882801

Chicago

Behçet, Mustafa, Ayça Çisem Harre, Fatma Avcıoğlu, et al. 2026. “Genotype Distribution of Hepatitis C Virus in Bolu Province”. European Journal of Life Sciences 5 (2): 89-95. https://doi.org/10.55971/EJLS.1882801.

EndNote

Behçet M, Harre AÇ, Avcıoğlu F, Çelik HB, Soysal E, Afşar Y, Kurtoğlu MG (August 1, 2026) Genotype distribution of hepatitis C virus in Bolu province. European Journal of Life Sciences 5 2 89–95.

IEEE

[1]M. Behçet et al., “Genotype distribution of hepatitis C virus in Bolu province”, Eur J Life Sci, vol. 5, no. 2, pp. 89–95, Aug. 2026, doi: 10.55971/EJLS.1882801.

ISNAD

Behçet, Mustafa - Harre, Ayça Çisem - Avcıoğlu, Fatma - Çelik, Hakan Burak - Soysal, Elif - Afşar, Yusuf - Kurtoğlu, Muhammet Güzel. “Genotype Distribution of Hepatitis C Virus in Bolu Province”. European Journal of Life Sciences 5/2 (August 1, 2026): 89-95. https://doi.org/10.55971/EJLS.1882801.

JAMA

1.Behçet M, Harre AÇ, Avcıoğlu F, Çelik HB, Soysal E, Afşar Y, Kurtoğlu MG. Genotype distribution of hepatitis C virus in Bolu province. Eur J Life Sci. 2026;5:89–95.

MLA

Behçet, Mustafa, et al. “Genotype Distribution of Hepatitis C Virus in Bolu Province”. European Journal of Life Sciences, vol. 5, no. 2, Aug. 2026, pp. 89-95, doi:10.55971/EJLS.1882801.

Vancouver

1.Mustafa Behçet, Ayça Çisem Harre, Fatma Avcıoğlu, Hakan Burak Çelik, Elif Soysal, Yusuf Afşar, Muhammet Güzel Kurtoğlu. Genotype distribution of hepatitis C virus in Bolu province. Eur J Life Sci. 2026 Aug. 1;5(2):89-95. doi:10.55971/EJLS.1882801