Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method

Abdullah Biçer; Gökhan Sevinç

doi:10.55971/EJLS.1896819

Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method

Abstract

In this study, the antioxidant properties of some thiazole compounds were investigated using the DPPH and CUPRAC methods. Urea, amide, and benzyl-substituted thiazole compounds (11, 12, 13) were synthesized from the reactions of 4-phenyl-2-aminothiazole with phenyl isocyanate, acetyl chloride, and benzyl chloride, respectively. In addition, compound (17) was obtained from 4-bromoacetophenone, and compound (15) was obtained from the formylation reactions of compounds (13) and (12). In addition, the synthesis strategies of thiazole compounds are outlined, with particular emphasis on product formation in formylation reactions. The measurement of antioxidant capacity plays an important role in the synthesis of bioactive heterocyclic compounds with therapeutic potential. Compound (17) (13.7% RSC) showed the best DPPH activity (Reference trolox 84 %). When the CUPRAC test was applied to compound (17), the TEAC value (Trolox equivalent antioxidant capacity) was found to be 1.75±0.018. The results reveal that compound (17) possesses poor radical scavenging ability while maintaining significant reducing strength.

Keywords

Project Number

2023- 01.BŞEÜ.35-04

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Details

Primary Language

English

Subjects

Medicinal and Biomolecular Chemistry (Other)

Journal Section

Research Article

Authors

Abdullah Biçer ^*
0000-0003-4648-1834
Türkiye

Gökhan Sevinç
0000-0002-7008-1067
Türkiye

Publication Date

August 31, 2026

Submission Date

February 24, 2026

Acceptance Date

May 15, 2026

Published in Issue

Year 2026 Volume: 5 Number: 2

DOI

https://doi.org/10.55971/EJLS.1896819

IZ

https://izlik.org/JA53AT64MB

Cite

RIS / Bibtex

APA

Biçer, A., & Sevinç, G. (2026). Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method. European Journal of Life Sciences, 5(2), 96-102. https://doi.org/10.55971/EJLS.1896819

AMA

1.Biçer A, Sevinç G. Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method. Eur J Life Sci. 2026;5(2):96-102. doi:10.55971/EJLS.1896819

Chicago

Biçer, Abdullah, and Gökhan Sevinç. 2026. “Determination of the Antioxidant Capacity of Some Thiazole Derivatives Using the CUPRAC and DPPH Method”. European Journal of Life Sciences 5 (2): 96-102. https://doi.org/10.55971/EJLS.1896819.

EndNote

Biçer A, Sevinç G (August 1, 2026) Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method. European Journal of Life Sciences 5 2 96–102.

IEEE

[1]A. Biçer and G. Sevinç, “Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method”, Eur J Life Sci, vol. 5, no. 2, pp. 96–102, Aug. 2026, doi: 10.55971/EJLS.1896819.

ISNAD

Biçer, Abdullah - Sevinç, Gökhan. “Determination of the Antioxidant Capacity of Some Thiazole Derivatives Using the CUPRAC and DPPH Method”. European Journal of Life Sciences 5/2 (August 1, 2026): 96-102. https://doi.org/10.55971/EJLS.1896819.

JAMA

1.Biçer A, Sevinç G. Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method. Eur J Life Sci. 2026;5:96–102.

MLA

Biçer, Abdullah, and Gökhan Sevinç. “Determination of the Antioxidant Capacity of Some Thiazole Derivatives Using the CUPRAC and DPPH Method”. European Journal of Life Sciences, vol. 5, no. 2, Aug. 2026, pp. 96-102, doi:10.55971/EJLS.1896819.

Vancouver

1.Abdullah Biçer, Gökhan Sevinç. Determination of the antioxidant capacity of some thiazole derivatives using the CUPRAC and DPPH method. Eur J Life Sci. 2026 Aug. 1;5(2):96-102. doi:10.55971/EJLS.1896819