Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration

Zişan Fatma Beyaz; Emre Öztürk; Adem Kara

Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration

Abstract

Cancer's standard treatment is generally based on cytotoxic drugs, radiotherapy, chemotherapy, and surgery. One treatment type in the study is phytotherapy, which uses plant components to treat diseases or improve health. Oleuropein, obtained from olive leaves, is active in olive leaves and fruit. It affects health, such as skin protection, anti-aging, antiviral, and antioxidants. Recent studies have proven that it positively affects humans, including cancer prevention and antimicrobial properties. The other substance to be combined with oleuropein is vitamin C, which has an essential function in the body, inactivates carcinogenic substances taken into the body, and is a known antioxidant that forms a shield against cancer. We will investigate the therapeutic effects of combining oleuropein and vitamin C on head-neck cancer cells (Fadu). We conducted cell viability and scratch (migration) analyses on Fadu cells treated with oleuropein and/or vitamin C at different doses for 24 hours. The cell viability analyses showed that oleuropein and vitamin C treatments significantly reduced cell viability. At the same time, the combined applications of oleuropein and vitamin C also considerably reduced cell viability. In the cell migration test, we observed that oleuropein or vitamin C alone increased the migration while the combined applications significantly reduced it. The results indicate that applying oleuropein or vitamin C leads to decreased cell viability. However, the combined applications of oleuropein and vitamin C offer an effective treatment option by reducing cell viability and migration.

Keywords

Oleuropein, Vitamin C, head and neck cancer, Cancer

References

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Details

Primary Language

English

Subjects

Plant Cell and Molecular Biology, Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Authors

Zişan Fatma Beyaz
0009-0008-0856-5133
Türkiye

Emre Öztürk ^*
0000-0002-5847-0721
Türkiye

Adem Kara
0000-0002-5766-6116
Türkiye

Early Pub Date

July 21, 2025

Publication Date

July 13, 2025

Submission Date

March 27, 2025

Acceptance Date

July 1, 2025

Published in Issue

Year 2025 Volume: 4 Number: 1

IZ

https://izlik.org/JA49FB44MJ

APA

Beyaz, Z. F., Öztürk, E., & Kara, A. (2025). Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration. Eurasian Journal of Molecular and Biochemical Sciences, 4(1), 11-17. https://izlik.org/JA49FB44MJ

AMA

1.Beyaz ZF, Öztürk E, Kara A. Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration. Eurasian Mol Biochem Sci. 2025;4(1):11-17. https://izlik.org/JA49FB44MJ

Chicago

Beyaz, Zişan Fatma, Emre Öztürk, and Adem Kara. 2025. “Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration”. Eurasian Journal of Molecular and Biochemical Sciences 4 (1): 11-17. https://izlik.org/JA49FB44MJ.

EndNote

Beyaz ZF, Öztürk E, Kara A (July 1, 2025) Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration. Eurasian Journal of Molecular and Biochemical Sciences 4 1 11–17.

IEEE

[1]Z. F. Beyaz, E. Öztürk, and A. Kara, “Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration”, Eurasian Mol Biochem Sci, vol. 4, no. 1, pp. 11–17, July 2025, [Online]. Available: https://izlik.org/JA49FB44MJ

ISNAD

Beyaz, Zişan Fatma - Öztürk, Emre - Kara, Adem. “Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration”. Eurasian Journal of Molecular and Biochemical Sciences 4/1 (July 1, 2025): 11-17. https://izlik.org/JA49FB44MJ.

JAMA

1.Beyaz ZF, Öztürk E, Kara A. Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration. Eurasian Mol Biochem Sci. 2025;4:11–17.

MLA

Beyaz, Zişan Fatma, et al. “Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration”. Eurasian Journal of Molecular and Biochemical Sciences, vol. 4, no. 1, July 2025, pp. 11-17, https://izlik.org/JA49FB44MJ.

Vancouver

1.Zişan Fatma Beyaz, Emre Öztürk, Adem Kara. Evaluating the Synergistic Effects of Oleuropein and Vitamin C on Head and Neck Cancer Cell Viability and Migration. Eurasian Mol Biochem Sci [Internet]. 2025 Jul. 1;4(1):11-7. Available from: https://izlik.org/JA49FB44MJ