Determination of the potential of 5-Hydroxy-L-tryptophan and L-tryptophan as therapeutic agents for prostate cancer

Year 2022, Volume: 1 Issue: 2, 19 - 25, 01.11.2022

Özlem Özdemir Nursena Yüksel Tuğba Gezmiş Arzugül Tanas

Abstract

Prostate cancer is the second leading cause of death from cancer in men. Androgen deprivation therapy (ADT) is used as the
standard treatment in prostate cancer, and this treatment has undesirable side effects over time. There is a need for more
effective, safe compounds that occur naturally under the influence of these undesirable limitations. In this study, the anticancer
potentials of 5-Hydroxy-L-tryptophan (5-HTP) and L-tryptophan, which are thought to have various inhibitory potential
on cancer and its mechanisms, were studied. The study results showed that 5-HTP has a significant inhibition in prostate cancer
cells. This study is an important preliminary screening for new and effective molecule trials. In order to develop a possible
treatment strategy and to use these molecules as new therapeutic agents, further studies are needed in order to obtain more
comprehensive data on the mechanisms of action of these molecules and to investigate their possible effects in other cancer
types, and the obtained data should be supported by these studies.

Keywords

Prostate cancer, 5-Hydroxy-L-tryptophan, L-tryptophan, MTT assay, LDH release