Adjuvant therapies in mandibular distraction osteogenesis: Hormonal and pharmacological agents

Abstract

Distraction osteogenesis is a technique in which the callus formed between the bone segments removed by traction turns into new bone formation. It is used in the treatment of various defects in the maxillofacial region. The distraction technique has significant advantages over soft tissues. However, the long duration of treatment is an important disadvantage. In recent years, studies have been carried out on many materials and methods that can shorten the distraction process, and it has been shown that various hormonal proteins and pharmacological agents can be successful in distraction osteogenesis. In this review, we present a comprehensive review of hormonal proteins and pharmacological agents investigated in mandibular distraction osteogenesis.

Keywords

• distraction
• adjuvant therapy
• mandibular distraction osteogenesis

Mandibular Distraksiyon Osteogenezinde Adjuvan tedaviler: Hormonal ve Farmakolojik Ajanlar

Abstract

Distraksiyon osteogenezi traksiyon uygulanarak birbirinden uzaklaştırılan kemik segmentlerinin arasında oluşan kallusun yeni kemik formasyonuna dönüştüğü bir tekniktir ve maksillofasiyal bölgedeki çeşitli defektlerin tedavisinde kullanılır. Distraksiyon tekniğinin yumuşak dokular üzerinde önemli avantajlara sahiptir. Ancak tedavi süresinin uzun olması önemli bir dezavantajdır. Son yıllarda distraksiyon sürecini kısaltabilecek pek çok materyal ve metot üzerinde çalışmalar yapılmış, çeşitli hormonal proteinler, farmakolojik ajanların distraksiyon osteogenezinde başarılı olabileceği gösterilmiştir. Bu derlemede mandibular distraksiyon osteogenezinde araştırılan hormonal proteinlerin ve farmakolojik ajanların kapsamlı bir incelemesini sunduk.

Keywords

• distraksiyon
• adjuvan tedavi
• mandibular distraksiyon osteogenezi

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