Case Report

Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded

Volume: 7 Number: 2 August 20, 2024
  • Janakiram T N
  • Soumya Sampath
  • Mansi A. R. Venktaramanan
  • Arunkumar G
European Journal of Rhinology and Allergy Cover
European Journal of Rhinology and Allergy
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Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded

Abstract

Nasopharyngeal angiofibroma is a relatively rare tumor, which is locally aggressive and histologically benign with transformation to a malignant sarcomatous form in a previously irradiated candidate. Here we are reporting the second known case according to literature of a non irradiated case of nasopharyngeal angiofibroma who was previously operated 11 times for the excision of nasopharyngeal angiofibroma. All the previous biopsy reports were proven to be of nasopharyngeal angiofibroma, but for the last time, when he was operated at our center, biopsy showed malignant transformation of nasopharyngeal angiofibroma. The patient was then subjected to intensity modulated radiotherapy and is in close surveillance, doing well till date. Hence this case presentation gives an insight about malignant transformation of nasopharyngeal angiofibroma in absence of irradiation, which is a very rare entity.

Keywords

References

  1. Hodges JM, McDevitt AS, El-Sayed AI, Sebelik ME. Juvenile nasopharyngeal angiofibroma: current treatment modalities and future considerations. Indian J Otolaryngol Head Neck Surg. 2010;62(3):236-247.
  2. Glad H, Vainer B, Buchwald C, et al. Juvenile nasopharyngeal angiofibromas in Denmark 1981-2003: diagnosis, incidence, and treatment. Acta Otolaryngol. 2007;127(3):292-299.
  3. Hwang HC, Mills SE, Patterson K, Gown AM. Expression of androgen receptors in nasopharyngeal angiofibroma: an immunohistochemical study of 24 cases. Mod Pathol. 1998;11(11):1122-1126.
  4. Panda S, Rajeshwari M, Singh CA, Sharma SC, Sakthivel P. Radiation-induced sarcoma originating in recurrent juvenile nasopharyngeal angiofibroma. Case Rep Oncol Med. 2018;2018:5695803.
  5. Makek MS, Andrews JC, Fisch U. Malignant transformation of a nasopharyngeal angiofibroma. Laryngoscope. 1989;99(10 Pt 1):1088-1092.
  6. Donald PJ. Sarcomatous degeneration in a nasopharyngeal angiofibroma. Otolaryngol Head Neck Surg (1979). 1979;1979(87):42-46.
  7. Thiagarajan A, Iyer NG. Radiation-induced sarcomas of the head and neck. World J Clin Oncol. 2014;5(5):973-981.
  8. Pryor SG, Moore EJ, Kasperbauer JL. Endoscopic versus traditional approaches for excision of juvenile nasopharyngeal angiofibroma. Laryngoscope. 2005;115(7):1201-1207.

Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Case Report

Authors

Mansi A. R. Venktaramanan This is me
0000-0002-4423-5026
India

Publication Date

August 20, 2024

Submission Date

April 19, 2024

Acceptance Date

May 4, 2024

Published in Issue

Year 2024 Volume: 7 Number: 2

DOI

https://doi.org/10.5152/ejra.2024.24137

IZ

https://izlik.org/JA39JJ53YY

Cite

RIS / Bibtex
APA
T N, J., Sampath, S., Venktaramanan, M. A. R., & G, A. (2024). Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded. European Journal of Rhinology and Allergy, 7(2), 76-80. https://doi.org/10.5152/ejra.2024.24137
AMA
1.T N J, Sampath S, Venktaramanan MAR, G A. Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded. Eur J Rhinol Allergy. 2024;7(2):76-80. doi:10.5152/ejra.2024.24137
Chicago
T N, Janakiram, Soumya Sampath, Mansi A. R. Venktaramanan, and Arunkumar G. 2024. “Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-Irradiated Case: A Rarity Denuded”. European Journal of Rhinology and Allergy 7 (2): 76-80. https://doi.org/10.5152/ejra.2024.24137.
EndNote
T N J, Sampath S, Venktaramanan MAR, G A (August 1, 2024) Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded. European Journal of Rhinology and Allergy 7 2 76–80.
IEEE
[1]J. T N, S. Sampath, M. A. R. Venktaramanan, and A. G, “Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded”, Eur J Rhinol Allergy, vol. 7, no. 2, pp. 76–80, Aug. 2024, doi: 10.5152/ejra.2024.24137.
ISNAD
T N, Janakiram - Sampath, Soumya - Venktaramanan, Mansi A. R. - G, Arunkumar. “Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-Irradiated Case: A Rarity Denuded”. European Journal of Rhinology and Allergy 7/2 (August 1, 2024): 76-80. https://doi.org/10.5152/ejra.2024.24137.
JAMA
1.T N J, Sampath S, Venktaramanan MAR, G A. Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded. Eur J Rhinol Allergy. 2024;7:76–80.
MLA
T N, Janakiram, et al. “Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-Irradiated Case: A Rarity Denuded”. European Journal of Rhinology and Allergy, vol. 7, no. 2, Aug. 2024, pp. 76-80, doi:10.5152/ejra.2024.24137.
Vancouver
1.Janakiram T N, Soumya Sampath, Mansi A. R. Venktaramanan, Arunkumar G. Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded. Eur J Rhinol Allergy. 2024 Aug. 1;7(2):76-80. doi:10.5152/ejra.2024.24137

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