Review Article
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Laryngopharyngeal Reflux and Eye: More Than a Hypothesis

Year 2023, Volume: 6 Issue: 1, 1 - 4, 30.04.2023

Valerio Damiani Antonio Schindler Vitaliana Luccarelli Giorgio Ciprandi

https://doi.org/10.5152/ejra.2023.222785

Abstract

Objective: Laryngopharyngeal reflux is a frequent medical condition affecting about 1/3 of the general population. Also, laryngopharyngeal reflux may involve the ocular surface. Dry eye disease is also a common disorder affecting any age. Dry eye disease is a multifactorial disease sustained by different causes.

Methods: We reviewed the most recent evidence about the relationship between laryngopharyngeal reflux and eye.

Results: There is documentation that pepsin may be detectable in the tears of laryngopharyngeal reflux patients. Notably, pepsin is produced only in the stomach, so it is a biomarker of gastric reflux. There is also the demonstration that patients with dry eye disease may have frequent laryngopharyngeal reflux comorbidity, and dry eye disease severity is associated with high odds of laryngopharyngeal reflux comorbidity. In addition, a preliminary trial suggested that treating also laryngopharyngeal reflux in dry eye disease patients with gastric reflux could be a promising
strategy. As a result, it is conceivable to imagine that eye reflux could be a new nosologic entity. It seems reasonable to recommend that the management of laryngopharyngeal reflux patients should include the investigation of possible ocular comorbidity.

Conclusions: Laryngopharyngeal reflux and dry eye disease are 2 common diseases that not rarely can be associated together. Thus, careful attention to these disorders should be paid to in clinical practice by otolaryngologists visiting patients with laryngopharyngeal reflux.

Keywords

Laryngopharyngeal reflux eye reflux symptoms comorbidity treatment

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Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Review Article
Authors

Valerio Damiani This is me 0000-0002-9717-9275

Antonio Schindler This is me 0000-0002-8767-5179

Vitaliana Luccarelli This is me 0009-0004-7546-0092

Giorgio Ciprandi This is me 0000-0001-7016-8421

Publication Date April 30, 2023
Published in Issue Year 2023 Volume: 6 Issue: 1

Cite

APA Damiani, V., Schindler, A., Luccarelli, V., & Ciprandi, G. (2023). Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. European Journal of Rhinology and Allergy, 6(1), 1-4. https://doi.org/10.5152/ejra.2023.222785
AMA 1.Damiani V, Schindler A, Luccarelli V, Ciprandi G. Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. Eur J Rhinol Allergy. 2023;6(1):1-4. doi:10.5152/ejra.2023.222785
Chicago Damiani, Valerio, Antonio Schindler, Vitaliana Luccarelli, and Giorgio Ciprandi. 2023. “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”. European Journal of Rhinology and Allergy 6 (1): 1-4. https://doi.org/10.5152/ejra.2023.222785.
EndNote Damiani V, Schindler A, Luccarelli V, Ciprandi G (April 1, 2023) Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. European Journal of Rhinology and Allergy 6 1 1–4.
IEEE [1]V. Damiani, A. Schindler, V. Luccarelli, and G. Ciprandi, “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”, Eur J Rhinol Allergy, vol. 6, no. 1, pp. 1–4, Apr. 2023, doi: 10.5152/ejra.2023.222785.
ISNAD Damiani, Valerio - Schindler, Antonio - Luccarelli, Vitaliana - Ciprandi, Giorgio. “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”. European Journal of Rhinology and Allergy 6/1 (April 1, 2023): 1-4. https://doi.org/10.5152/ejra.2023.222785.
JAMA 1.Damiani V, Schindler A, Luccarelli V, Ciprandi G. Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. Eur J Rhinol Allergy. 2023;6:1–4.
MLA Damiani, Valerio, et al. “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”. European Journal of Rhinology and Allergy, vol. 6, no. 1, Apr. 2023, pp. 1-4, doi:10.5152/ejra.2023.222785.
Vancouver 1.Damiani V, Schindler A, Luccarelli V, Ciprandi G. Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. Eur J Rhinol Allergy [Internet]. 2023 Apr. 1;6(1):1-4. Available from: https://izlik.org/JA44SM37BX

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