Laryngopharyngeal Reflux and Eye: More Than a Hypothesis

Valerio Damiani; Antonio Schindler; Vitaliana Luccarelli; Giorgio Ciprandi

doi:10.5152/ejra.2023.222785

Laryngopharyngeal Reflux and Eye: More Than a Hypothesis

Abstract

Objective: Laryngopharyngeal reflux is a frequent medical condition affecting about 1/3 of the general population. Also, laryngopharyngeal reflux may involve the ocular surface. Dry eye disease is also a common disorder affecting any age. Dry eye disease is a multifactorial disease sustained by different causes. Methods: We reviewed the most recent evidence about the relationship between laryngopharyngeal reflux and eye. Results: There is documentation that pepsin may be detectable in the tears of laryngopharyngeal reflux patients. Notably, pepsin is produced only in the stomach, so it is a biomarker of gastric reflux. There is also the demonstration that patients with dry eye disease may have frequent laryngopharyngeal reflux comorbidity, and dry eye disease severity is associated with high odds of laryngopharyngeal reflux comorbidity. In addition, a preliminary trial suggested that treating also laryngopharyngeal reflux in dry eye disease patients with gastric reflux could be a promising strategy. As a result, it is conceivable to imagine that eye reflux could be a new nosologic entity. It seems reasonable to recommend that the management of laryngopharyngeal reflux patients should include the investigation of possible ocular comorbidity. Conclusions: Laryngopharyngeal reflux and dry eye disease are 2 common diseases that not rarely can be associated together. Thus, careful attention to these disorders should be paid to in clinical practice by otolaryngologists visiting patients with laryngopharyngeal reflux.

Keywords

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Review Article

Authors

Valerio Damiani This is me
0000-0002-9717-9275
Italy

Antonio Schindler This is me
0000-0002-8767-5179
Italy

Vitaliana Luccarelli This is me
0009-0004-7546-0092
Italy

Giorgio Ciprandi This is me
0000-0001-7016-8421
Italy

Publication Date

April 30, 2023

Submission Date

November 22, 2022

Acceptance Date

December 23, 2022

Published in Issue

Year 2023 Volume: 6 Number: 1

DOI

https://doi.org/10.5152/ejra.2023.222785

IZ

https://izlik.org/JA44SM37BX

Cite

RIS / Bibtex

APA

Damiani, V., Schindler, A., Luccarelli, V., & Ciprandi, G. (2023). Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. European Journal of Rhinology and Allergy, 6(1), 1-4. https://doi.org/10.5152/ejra.2023.222785

AMA

1.Damiani V, Schindler A, Luccarelli V, Ciprandi G. Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. Eur J Rhinol Allergy. 2023;6(1):1-4. doi:10.5152/ejra.2023.222785

Chicago

Damiani, Valerio, Antonio Schindler, Vitaliana Luccarelli, and Giorgio Ciprandi. 2023. “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”. European Journal of Rhinology and Allergy 6 (1): 1-4. https://doi.org/10.5152/ejra.2023.222785.

EndNote

Damiani V, Schindler A, Luccarelli V, Ciprandi G (April 1, 2023) Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. European Journal of Rhinology and Allergy 6 1 1–4.

IEEE

[1]V. Damiani, A. Schindler, V. Luccarelli, and G. Ciprandi, “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”, Eur J Rhinol Allergy, vol. 6, no. 1, pp. 1–4, Apr. 2023, doi: 10.5152/ejra.2023.222785.

ISNAD

Damiani, Valerio - Schindler, Antonio - Luccarelli, Vitaliana - Ciprandi, Giorgio. “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”. European Journal of Rhinology and Allergy 6/1 (April 1, 2023): 1-4. https://doi.org/10.5152/ejra.2023.222785.

JAMA

1.Damiani V, Schindler A, Luccarelli V, Ciprandi G. Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. Eur J Rhinol Allergy. 2023;6:1–4.

MLA

Damiani, Valerio, et al. “Laryngopharyngeal Reflux and Eye: More Than a Hypothesis”. European Journal of Rhinology and Allergy, vol. 6, no. 1, Apr. 2023, pp. 1-4, doi:10.5152/ejra.2023.222785.

Vancouver

1.Valerio Damiani, Antonio Schindler, Vitaliana Luccarelli, Giorgio Ciprandi. Laryngopharyngeal Reflux and Eye: More Than a Hypothesis. Eur J Rhinol Allergy. 2023 Apr. 1;6(1):1-4. doi:10.5152/ejra.2023.222785