Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future

Yoko Takahashi; Ehab Y. Hanna

doi:10.5152/ejra.2023.23092

Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future

Abstract

Sinonasal undifferentiated carcinoma is a rare and aggressive tumor. Despite aggressive management of patients, their prognosis is still poor. To better understand the biological features of sinonasal undifferentiated carcinoma and develop reliable therapeutic strategies for this disease, molecular characterization of sinonasal undifferentiated carcinoma is crucial. However, even nearly a decade ago, sinonasal undifferentiated carcinoma was still a poorly understood malignancy on both the clinical and molecular levels. The advent of next-generation sequencing technologies has resulted in a significant increase in the identification of molecular markers, including diagnostic and predictive markers, as well as gene alterations, leading to emerging distinct entities and new therapeutic approaches for sinonasal undifferentiated carcinoma. As new technologies continue to develop, new molecular markers for sinonasal undifferentiated carcinoma are expected to be discovered. Nevertheless, regardless of the methodology employed, sample size remains a crucial factor for the success of such investigations. Therefore, it is essential to establish a centralized banking system through multi-institutional collaboration. Additionally, investigation of the tumor microenvironment, including spatial immunophenotyping, is necessary to develop successful immunotherapy approaches.

Keywords

References

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Review Article

Authors

Yoko Takahashi This is me
0000-0003-2390-1998
United States

Ehab Y. Hanna This is me
0000-0003-3241-2440
United States

Publication Date

August 28, 2023

Submission Date

June 1, 2023

Acceptance Date

July 7, 2023

Published in Issue

Year 2023 Volume: 6 Number: 2

DOI

https://doi.org/10.5152/ejra.2023.23092

IZ

https://izlik.org/JA59UF46SA

Cite

RIS / Bibtex

APA

Takahashi, Y., & Hanna, E. Y. (2023). Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future. European Journal of Rhinology and Allergy, 6(2), 37-41. https://doi.org/10.5152/ejra.2023.23092

AMA

1.Takahashi Y, Hanna EY. Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future. Eur J Rhinol Allergy. 2023;6(2):37-41. doi:10.5152/ejra.2023.23092

Chicago

Takahashi, Yoko, and Ehab Y. Hanna. 2023. “Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future”. European Journal of Rhinology and Allergy 6 (2): 37-41. https://doi.org/10.5152/ejra.2023.23092.

EndNote

Takahashi Y, Hanna EY (August 1, 2023) Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future. European Journal of Rhinology and Allergy 6 2 37–41.

IEEE

[1]Y. Takahashi and E. Y. Hanna, “Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future”, Eur J Rhinol Allergy, vol. 6, no. 2, pp. 37–41, Aug. 2023, doi: 10.5152/ejra.2023.23092.

ISNAD

Takahashi, Yoko - Hanna, Ehab Y. “Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future”. European Journal of Rhinology and Allergy 6/2 (August 1, 2023): 37-41. https://doi.org/10.5152/ejra.2023.23092.

JAMA

1.Takahashi Y, Hanna EY. Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future. Eur J Rhinol Allergy. 2023;6:37–41.

MLA

Takahashi, Yoko, and Ehab Y. Hanna. “Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future”. European Journal of Rhinology and Allergy, vol. 6, no. 2, Aug. 2023, pp. 37-41, doi:10.5152/ejra.2023.23092.

Vancouver

1.Yoko Takahashi, Ehab Y. Hanna. Molecular Characterization of Sinonasal Undifferentiated Carcinoma—Past, Present, and Future. Eur J Rhinol Allergy. 2023 Aug. 1;6(2):37-41. doi:10.5152/ejra.2023.23092