Abstract
Chronic rhinosinusitis (CRS) is associated with the failure of the mechanical and immunologic barriers across the nasal mucosa. Considering the innate immune barrier our attention has focused on HMGB1 a protein released actively by immunocompetent cells, under different stimuli, and passively by necrotic cells as danger signal.
Once released, it acts at nuclear level on NF-kB attracting inflammatory cells, activating dendritic cells, promoting their functional maturation and increasing eosinophils activity and survival.
We analysed HMGB1 characteristics and functions on the respiratory epithelium during rhinosinusal inflammation.
Keywords
References
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Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Editorial |
| Authors | |
| Publication Date | April 1, 2022 |
| Published in Issue | Year 2022 Volume: 5 Issue: 1 |
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