The second saddle of a therapeutic tandem in rhinosinusitis treatment

Desiderio Passali; Luisa Maria Bellussi; Franceso Maria Passali

The second saddle of a therapeutic tandem in rhinosinusitis treatment

Abstract

Chronic rhinosinusitis (CRS) is associated with the failure of the mechanical and immunologic barriers across the nasal mucosa. Considering the innate immune barrier our attention has focused on HMGB1 a protein released actively by immunocompetent cells, under different stimuli, and passively by necrotic cells as danger signal. Once released, it acts at nuclear level on NF-kB attracting inflammatory cells, activating dendritic cells, promoting their functional maturation and increasing eosinophils activity and survival. We analysed HMGB1 characteristics and functions on the respiratory epithelium during rhinosinusal inflammation.

Keywords

References

Chen D, Bellussi LM, Passali D, Chen L. LPS may enhance expression and release of HMGB1 in human nasal epithelial cells in vitro. Acta Otorhinolaryngol Ital. 2013;33(6):398-404.
Chen D, Mao M, Bellussi LM, Passali D, Chen L. Increase of high mobility group box chromosomal protein 1 in eosinophilic chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014;4(6):453-462.
Bellussi LM, Iosif C, Sarafoleanu C, et al. Are HMGB1 protein expression and secretion markers of upper airways inflammatory diseases? J Biol Regul Homeost Agents. 2013;27(3):791-804.
Chen D, Bellussi LM, Cocca S, et al. Glycyrrhetinic acid suppressed HMGB1 release by up-regulation of Sirt6 in nasal inflammation. J Biol Regul Homeost Agents. 2017;31(2):269-277.
Passali D, Cappello C, Passali GC,Cingi C, Sarafoleanu C, Bellussi LM. Nasal muco-ciliary tran sport time alteration:efficacy of 18-β glycyrrhetic acid. Multidiscip Respir Med. 2017;29:12-29.

Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Editorial

Authors

Desiderio Passali This is me
0000-0002-4791-012X
Italy

Luisa Maria Bellussi This is me
0000-0001-6187-2855
Italy

Franceso Maria Passali This is me
0000-0003-4032-8230
Italy

Publication Date

April 1, 2022

Submission Date

January 1, 2022

Acceptance Date

January 2, 2022

Published in Issue

Year 2022 Volume: 5 Number: 1

IZ

https://izlik.org/JA94RP53DR

Cite

RIS / Bibtex

APA

Passali, D., Bellussi, L. M., & Passali, F. M. (2022). The second saddle of a therapeutic tandem in rhinosinusitis treatment. European Journal of Rhinology and Allergy, 5(1), 1-2. https://izlik.org/JA94RP53DR

AMA

1.Passali D, Bellussi LM, Passali FM. The second saddle of a therapeutic tandem in rhinosinusitis treatment. Eur J Rhinol Allergy. 2022;5(1):1-2. https://izlik.org/JA94RP53DR

Chicago

Passali, Desiderio, Luisa Maria Bellussi, and Franceso Maria Passali. 2022. “The Second Saddle of a Therapeutic Tandem in Rhinosinusitis Treatment”. European Journal of Rhinology and Allergy 5 (1): 1-2. https://izlik.org/JA94RP53DR.

EndNote

Passali D, Bellussi LM, Passali FM (April 1, 2022) The second saddle of a therapeutic tandem in rhinosinusitis treatment. European Journal of Rhinology and Allergy 5 1 1–2.

IEEE

[1]D. Passali, L. M. Bellussi, and F. M. Passali, “The second saddle of a therapeutic tandem in rhinosinusitis treatment”, Eur J Rhinol Allergy, vol. 5, no. 1, pp. 1–2, Apr. 2022, [Online]. Available: https://izlik.org/JA94RP53DR

ISNAD

Passali, Desiderio - Bellussi, Luisa Maria - Passali, Franceso Maria. “The Second Saddle of a Therapeutic Tandem in Rhinosinusitis Treatment”. European Journal of Rhinology and Allergy 5/1 (April 1, 2022): 1-2. https://izlik.org/JA94RP53DR.

JAMA

1.Passali D, Bellussi LM, Passali FM. The second saddle of a therapeutic tandem in rhinosinusitis treatment. Eur J Rhinol Allergy. 2022;5:1–2.

MLA

Passali, Desiderio, et al. “The Second Saddle of a Therapeutic Tandem in Rhinosinusitis Treatment”. European Journal of Rhinology and Allergy, vol. 5, no. 1, Apr. 2022, pp. 1-2, https://izlik.org/JA94RP53DR.

Vancouver

1.Desiderio Passali, Luisa Maria Bellussi, Franceso Maria Passali. The second saddle of a therapeutic tandem in rhinosinusitis treatment. Eur J Rhinol Allergy [Internet]. 2022 Apr. 1;5(1):1-2. Available from: https://izlik.org/JA94RP53DR