The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study

Onur Ergün; Taner Yılmaz; Ayşegül Süzer; Sevda Fatma Müftüoğlu

doi:10.5152/ejra.2021.324

The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study

Abstract

Objective: The concept of compensatory turbinate hypertrophy (CTH) has found a frequent mention in research works. However, despite its clinical significance, there is a paucity in the research of regulatory mechanisms of CTH process at the cellular levels. The objective of this study is to assess the importance of apoptosis in the CTH process and understand nasal physiology. Material and Methods: In total, 23 adults who underwent septoplasty and partial turbinectomy for the management of unilateral nasal septal deviations (NSD) and CTH were included in this study. Turbinectomy specimens were immunohistochemically evaluated using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) stain and anti-human-activated pro-Caspase 3 monoclonal antibody stains. Percentages of apoptotic cells (apoptotic index [AI]) were determined at various cell types. The statistical analysis was based on the AI differences between the hypertrophic and non-hypertrophic turbinates of the same patient. A subgroup analysis was also performed to evaluate the effect of smoking on AIs. Results: No cell type had statistically significant AI differences between the hypertrophic and non-hypertrophic turbinates. Vascular smooth muscle cells of the CTH side had slightly lower AIs although this trend was statistically not significant (Caspase 3, p = 0.066). No difference in AIs was detected at the other cell types. Similarly, no AI difference related to smoking could be observed. Conclusions: Our results have not shown any significant differences among AIs of many cell types between opposite turbinates or between smokers and nonsmokers. Therefore, apoptosis has not found to be active as a mechanism of regulation for the CTH of adults with stable NSDs.

Keywords

References

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Onur Ergün This is me
0000-0002-9252-0462
Türkiye

Taner Yılmaz
0000-0001-8999-3237
Türkiye

Ayşegül Süzer
0000-0002-0899-6258
Türkiye

Sevda Fatma Müftüoğlu This is me
0000-0003-0664-0204
Türkiye

Publication Date

April 1, 2021

Submission Date

November 12, 2020

Acceptance Date

December 13, 2020

Published in Issue

Year 2021 Volume: 4 Number: 1

DOI

https://doi.org/10.5152/ejra.2021.324

IZ

https://izlik.org/JA39WL36TB

Cite

RIS / Bibtex

APA

Ergün, O., Yılmaz, T., Süzer, A., & Müftüoğlu, S. F. (2021). The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study. European Journal of Rhinology and Allergy, 4(1), 1-6. https://doi.org/10.5152/ejra.2021.324

AMA

1.Ergün O, Yılmaz T, Süzer A, Müftüoğlu SF. The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study. Eur J Rhinol Allergy. 2021;4(1):1-6. doi:10.5152/ejra.2021.324

Chicago

Ergün, Onur, Taner Yılmaz, Ayşegül Süzer, and Sevda Fatma Müftüoğlu. 2021. “The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study”. European Journal of Rhinology and Allergy 4 (1): 1-6. https://doi.org/10.5152/ejra.2021.324.

EndNote

Ergün O, Yılmaz T, Süzer A, Müftüoğlu SF (April 1, 2021) The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study. European Journal of Rhinology and Allergy 4 1 1–6.

IEEE

[1]O. Ergün, T. Yılmaz, A. Süzer, and S. F. Müftüoğlu, “The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study”, Eur J Rhinol Allergy, vol. 4, no. 1, pp. 1–6, Apr. 2021, doi: 10.5152/ejra.2021.324.

ISNAD

Ergün, Onur - Yılmaz, Taner - Süzer, Ayşegül - Müftüoğlu, Sevda Fatma. “The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study”. European Journal of Rhinology and Allergy 4/1 (April 1, 2021): 1-6. https://doi.org/10.5152/ejra.2021.324.

JAMA

1.Ergün O, Yılmaz T, Süzer A, Müftüoğlu SF. The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study. Eur J Rhinol Allergy. 2021;4:1–6.

MLA

Ergün, Onur, et al. “The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study”. European Journal of Rhinology and Allergy, vol. 4, no. 1, Apr. 2021, pp. 1-6, doi:10.5152/ejra.2021.324.

Vancouver

1.Onur Ergün, Taner Yılmaz, Ayşegül Süzer, Sevda Fatma Müftüoğlu. The Role of Apoptosis at the Compensatory Turbinate Hypertrophy Secondary to Nasal Septum Deviation: A Case Control Study. Eur J Rhinol Allergy. 2021 Apr. 1;4(1):1-6. doi:10.5152/ejra.2021.324