Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status

Vandana Aravind; Nedha Joy; Thenmozhi Mani; Vedantam Rupa

doi:10.5152/ejra.2021.21317

Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status

Abstract

Objective: We aimed to correlate post-operative endoscopic disease status and reduction in serum total IgE levels in patients with allergic fungal rhinosinusitis (AFRS) and to ascertain whether this reduction has prognostic significance. Material and Methods: A prospective cohort of 50 patients with biopsy-proven AFRS underwent preoperative endoscopy and serum total IgE assessment. Following endoscopic excision of polyps and allergic mucin and postoperative steroid therapy, patients were re-evaluated at 3-6 months with nasal endoscopy with Kupferberg staging and serum total IgE levels. Results: There were 27 (54%) male and 23 (46%) female patients. Preoperative endoscopy showed grade 3 polyps in 33 (66%) patients and grade 2 polyps in 17 (34%) patients. Post-operatively, 37 (74%) patients had Stage 0, 11 (22%) had Stage 1, and two (4%) had Stage 2 diseases. Preoperative IgE levels ranged from 153.2 to 6,548.2 IU mL 1. Post operative IgE levels were reduced in 42 of 50 (84%) patients and ranged from 79.9 to 3,900 IU mL 1. There was a negative correlation between percentage change in IgE and post-operative endoscopic score, which was significant (r¼ 0.25; P¼ .032). Based on receiver operating characteristic analysis, a percentage reduction in IgE of 32% had a sensitivity of 69.2% (95% CI: 38.6-90.9) and specificity of 67.6% (95% CI: 50.2-82.0) in predicting endoscopic stage. Conclusion: Post-operative reduction in serum total IgE levels negatively correlates with endoscopic stage in AFRS patients who undergo surgery and post-operative steroid therapy. A cutoff of 32% in change in IgE levels is predictive of endoscopic Stage 0 disease.

Keywords

References

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Details

Primary Language

English

Subjects

Allergy, Otorhinolaryngology

Journal Section

Research Article

Authors

Vandana Aravind This is me
0000-0001-7313-709X
India

Nedha Joy This is me
0000-0003-2735-4207
India

Thenmozhi Mani This is me
0000-0002-3932-5625
India

Vedantam Rupa This is me
0000-0001-9892-0064
India

Publication Date

August 30, 2021

Submission Date

February 16, 2021

Acceptance Date

March 13, 2021

Published in Issue

Year 2021 Volume: 4 Number: 2

DOI

https://doi.org/10.5152/ejra.2021.21317

IZ

https://izlik.org/JA48AU77AC

Cite

RIS / Bibtex

APA

Aravind, V., Joy, N., Mani, T., & Rupa, V. (2021). Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status. European Journal of Rhinology and Allergy, 4(2), 58-61. https://doi.org/10.5152/ejra.2021.21317

AMA

1.Aravind V, Joy N, Mani T, Rupa V. Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status. Eur J Rhinol Allergy. 2021;4(2):58-61. doi:10.5152/ejra.2021.21317

Chicago

Aravind, Vandana, Nedha Joy, Thenmozhi Mani, and Vedantam Rupa. 2021. “Change in Serum IgE Levels Following Surgery in Patients With Allergic Fungal Rhinosinusitis Is Predictive of Disease Status”. European Journal of Rhinology and Allergy 4 (2): 58-61. https://doi.org/10.5152/ejra.2021.21317.

EndNote

Aravind V, Joy N, Mani T, Rupa V (August 1, 2021) Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status. European Journal of Rhinology and Allergy 4 2 58–61.

IEEE

[1]V. Aravind, N. Joy, T. Mani, and V. Rupa, “Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status”, Eur J Rhinol Allergy, vol. 4, no. 2, pp. 58–61, Aug. 2021, doi: 10.5152/ejra.2021.21317.

ISNAD

Aravind, Vandana - Joy, Nedha - Mani, Thenmozhi - Rupa, Vedantam. “Change in Serum IgE Levels Following Surgery in Patients With Allergic Fungal Rhinosinusitis Is Predictive of Disease Status”. European Journal of Rhinology and Allergy 4/2 (August 1, 2021): 58-61. https://doi.org/10.5152/ejra.2021.21317.

JAMA

1.Aravind V, Joy N, Mani T, Rupa V. Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status. Eur J Rhinol Allergy. 2021;4:58–61.

MLA

Aravind, Vandana, et al. “Change in Serum IgE Levels Following Surgery in Patients With Allergic Fungal Rhinosinusitis Is Predictive of Disease Status”. European Journal of Rhinology and Allergy, vol. 4, no. 2, Aug. 2021, pp. 58-61, doi:10.5152/ejra.2021.21317.

Vancouver

1.Vandana Aravind, Nedha Joy, Thenmozhi Mani, Vedantam Rupa. Change in Serum IgE Levels Following Surgery in Patients with Allergic Fungal Rhinosinusitis is Predictive of Disease Status. Eur J Rhinol Allergy. 2021 Aug. 1;4(2):58-61. doi:10.5152/ejra.2021.21317