Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature

Mark B. Chaskes; Keonho Albert Kong; Brent Senior

doi:10.5152/ejra.2021.21050

Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature

Abstract

Chronic rhinosinusitis (CRS) is a common inflammatory syndrome of the paranasal sinuses. CRS with nasal polyposis (CRSwNP) is one of the two major phenotypes of CRS, with an estimated prevalence of 4.2% in the United States and 4.3% in Europe. While several inflammatory pathways may mediate this condition, an estimated 85% of patients with CRSwNP exhibit Th2 (Type 2) inflammation, characterized by an increase in local eosinophilia, total IgE, interleukin (IL)-4, IL-5, and IL-13. Biologic therapies have proven successful in the treatment of related, Th2-mediated inflammatory conditions, including asthma and atopic dermatitis. As such, there has been significant interest in the role of biologics in the treatment of CRSwNP. Biologics target specific immune cells or inflammatory mediators within the cascade, thus offering treatment efficacy while limiting side effects. There has been a rapid expansion of the literature regarding the role of biologics within the treatment paradigm of patients with medically and surgically recalcitrant CRSwNP. Currently, there are five biologics under investigation or approved for the treatment of CRSwNP by the US Food and Drug Administration. As the study of biologics in the role of CRSwNP management continues to grow at a rapid pace, remaining to date on all aspects of these novel treatment modalities will be critical for the otolaryngologist. Herein, we review the current literature regarding biologic therapy options and offer perspective on the future.

Keywords

References

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Review Article

Authors

Mark B. Chaskes This is me
0000-0001-7432-4217
United States

Keonho Albert Kong This is me
0000-0002-8443-103X
United States

Brent Senior This is me
0000-0002-1503-3150
United States

Publication Date

December 25, 2021

Submission Date

November 29, 2021

Acceptance Date

December 22, 2021

Published in Issue

Year 2021 Volume: 4 Number: 3

DOI

https://doi.org/10.5152/ejra.2021.21050

IZ

https://izlik.org/JA86CD54AP

Cite

RIS / Bibtex

APA

Chaskes, M. B., Kong, K. A., & Senior, B. (2021). Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature. European Journal of Rhinology and Allergy, 4(3), 72-76. https://doi.org/10.5152/ejra.2021.21050

AMA

1.Chaskes MB, Kong KA, Senior B. Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature. Eur J Rhinol Allergy. 2021;4(3):72-76. doi:10.5152/ejra.2021.21050

Chicago

Chaskes, Mark B., Keonho Albert Kong, and Brent Senior. 2021. “Biologic Therapy for the Treatment of Chronic Rhinosinusitis With Nasal Polyposis: An Update and Review of the Literature”. European Journal of Rhinology and Allergy 4 (3): 72-76. https://doi.org/10.5152/ejra.2021.21050.

EndNote

Chaskes MB, Kong KA, Senior B (December 1, 2021) Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature. European Journal of Rhinology and Allergy 4 3 72–76.

IEEE

[1]M. B. Chaskes, K. A. Kong, and B. Senior, “Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature”, Eur J Rhinol Allergy, vol. 4, no. 3, pp. 72–76, Dec. 2021, doi: 10.5152/ejra.2021.21050.

ISNAD

Chaskes, Mark B. - Kong, Keonho Albert - Senior, Brent. “Biologic Therapy for the Treatment of Chronic Rhinosinusitis With Nasal Polyposis: An Update and Review of the Literature”. European Journal of Rhinology and Allergy 4/3 (December 1, 2021): 72-76. https://doi.org/10.5152/ejra.2021.21050.

JAMA

1.Chaskes MB, Kong KA, Senior B. Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature. Eur J Rhinol Allergy. 2021;4:72–76.

MLA

Chaskes, Mark B., et al. “Biologic Therapy for the Treatment of Chronic Rhinosinusitis With Nasal Polyposis: An Update and Review of the Literature”. European Journal of Rhinology and Allergy, vol. 4, no. 3, Dec. 2021, pp. 72-76, doi:10.5152/ejra.2021.21050.

Vancouver

1.Mark B. Chaskes, Keonho Albert Kong, Brent Senior. Biologic Therapy for the Treatment of Chronic Rhinosinusitis with Nasal Polyposis: An Update and Review of the Literature. Eur J Rhinol Allergy. 2021 Dec. 1;4(3):72-6. doi:10.5152/ejra.2021.21050