Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles

Görkem Dündar; Serdar Özer; Ahmet Emre Süslü; Tevfik Metin Önerci

doi:10.5152/ejra.2019.208

Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles

Abstract

Objective: High neutrophil/lymphocyte ratio (NLR) is associated with high mortality and recurrence in various types of malignancy. Studies on the prognosis of benign masses in the literature are quite rare. The aim of this study was to investigate the association of preoperative NLR with recurrence in paranasal sinus mucoceles. Material and Methods: Demographic characteristics, hemogram values, distribution of mucoceles in paranasal sinuses, complaints of the patients, and their follow-up periods were retrospectively analyzed in patients with paranasal sinus mucocele at a tertiary care center between 2010 and 2017. Fischer’s exact test and Mann–Whitney U test were used for statistical analyses. Results: A total of 53 patients (25 females and 28 males) were operated. The preoperative NLRs were 1.92 (standard deviation (SD)=0.97), –2.15 (SD=1.07), and –1.99 (SD=1.08) for the frontoethmoid, maxillary, and sphenoid sinuses, respectively. After 24 months of follow-up (range, 14–84 months), recurrence was detected in four patients for the sphenoid sinus mucocele and in five patients for the frontoethmoid sinus mucocele. The mean recurrence time was 10 months. No statistically significant difference was found between the frontal and sphenoid sinus sites in terms of recurrence (p=2.15). The preoperative NLR of the patients with recurrence was found to be 2.39 (p=0.352) for mucoceles located in the sphenoid sinus and 3.106 (p=0.019) for mucoceles located in the frontoethmoid region. Conclusion: Preoperative high NLR can be used to show recurrence in the paranasal mucoceles of the frontoethmoid region. NLR is an inexpensive marker that is easily obtained from routine blood samples and may lead the clinician in the prognosis of frontoethmoid sinus mucocele patients.

Keywords

References

Scangas GA, Gudis DA, Kennedy DW. The natural history and clinical characteristics of paranasal sinus mucoceles: a clinical review. Int Forum Allergy Rhinol 2013; 3: 712-7.
Kim YS, Kim K, Lee JG, Yoon JH, Kim CH. Paranasal sinus mucoceles with ophthalmologic manifestations: a 17-year review of 96 cases. Am J Rhinol Allergy 2011; 25: 272-5.
Har-El G. Endoscopic management of 108 sinus mucoceles. Laryngoscope 2001; 111: 2131-4.
Zukin LM, Hink EM, Liao S, Getz AE, Kingdom TT, Ramakrishnan VR. Endoscopic Management of Paranasal Sinus Mucoceles: Meta-analysis of Visual Outcomes. Otolaryngol Head Neck Surg 2017; 157: 760-6.
Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. JNCI: Journal of the National Cancer Institute 2016; 106: https://doi.org/10.1093/jnci/dju124.
Tham T, Bardash Y, Herman SW, Costantino PD. Neutrophil-to-lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta-analysis. Head Neck 2018; 40: 2546-57.
Erdogan BA, Unlu N, Aydin S, Avci H. Frontal Mucocele Extended Orbita and Endoscopic Marsupialization Technique. J Craniofac Surg 2018; 29: 408-9.
Gulati R, Soni SK, Kumar A. Giant ethmoid mucocele presenting as an orbital mass. Indian J Otolaryngol Head Neck Surg 2015; 67: 97-9.

Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Görkem Dündar
0000-0002-1888-8218
Türkiye

Serdar Özer This is me
Türkiye

Ahmet Emre Süslü This is me
0000-0002-3345-5066
Türkiye

Tevfik Metin Önerci
0000-0002-1051-9135
Türkiye

Publication Date

December 7, 2019

Submission Date

September 26, 2019

Acceptance Date

November 6, 2019

Published in Issue

Year 2019 Volume: 2 Number: 3

DOI

https://doi.org/10.5152/ejra.2019.208

IZ

https://izlik.org/JA74TU69YP

Cite

RIS / Bibtex

APA

Dündar, G., Özer, S., Süslü, A. E., & Önerci, T. M. (2019). Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles. European Journal of Rhinology and Allergy, 2(3), 68-70. https://doi.org/10.5152/ejra.2019.208

AMA

1.Dündar G, Özer S, Süslü AE, Önerci TM. Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles. Eur J Rhinol Allergy. 2019;2(3):68-70. doi:10.5152/ejra.2019.208

Chicago

Dündar, Görkem, Serdar Özer, Ahmet Emre Süslü, and Tevfik Metin Önerci. 2019. “Prognostic Significance of Neutrophil Lymphocyte Ratio in Nasal Mucoceles”. European Journal of Rhinology and Allergy 2 (3): 68-70. https://doi.org/10.5152/ejra.2019.208.

EndNote

Dündar G, Özer S, Süslü AE, Önerci TM (December 1, 2019) Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles. European Journal of Rhinology and Allergy 2 3 68–70.

IEEE

[1]G. Dündar, S. Özer, A. E. Süslü, and T. M. Önerci, “Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles”, Eur J Rhinol Allergy, vol. 2, no. 3, pp. 68–70, Dec. 2019, doi: 10.5152/ejra.2019.208.

ISNAD

Dündar, Görkem - Özer, Serdar - Süslü, Ahmet Emre - Önerci, Tevfik Metin. “Prognostic Significance of Neutrophil Lymphocyte Ratio in Nasal Mucoceles”. European Journal of Rhinology and Allergy 2/3 (December 1, 2019): 68-70. https://doi.org/10.5152/ejra.2019.208.

JAMA

1.Dündar G, Özer S, Süslü AE, Önerci TM. Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles. Eur J Rhinol Allergy. 2019;2:68–70.

MLA

Dündar, Görkem, et al. “Prognostic Significance of Neutrophil Lymphocyte Ratio in Nasal Mucoceles”. European Journal of Rhinology and Allergy, vol. 2, no. 3, Dec. 2019, pp. 68-70, doi:10.5152/ejra.2019.208.

Vancouver

1.Görkem Dündar, Serdar Özer, Ahmet Emre Süslü, Tevfik Metin Önerci. Prognostic Significance of Neutrophil/Lymphocyte Ratio in Nasal Mucoceles. Eur J Rhinol Allergy. 2019 Dec. 1;2(3):68-70. doi:10.5152/ejra.2019.208