The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis

Fulya Özer; Soner Solmaz; Cüneyt Yılmazer

doi:10.5152/ejra.2019.37

The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis

Abstract

The beginning symptoms in patients with acute myeloid leukemia (AML) can show differences often because of mucocutaneous bleedings and leukemic infiltrations in the extramedullary area. Actually, nose bleeding is not an uncommon beginning symptom. However, these patients can be ignored easily in the emergency room, and serious complications can be seen. A 28-year-old female patient applied to our clinic to remove her nasal packing. Her nasal packing was placed 2 days ago in another clinic for bleeding during examination. Blood sample results showed that the patient had anemia and thrombocytopenia. The result of immunophenotyping was compatible with AML M3. After 1 day, subarachnoid hemorrhage was detected on computed tomography. She had a convulsion, and her saturation decreased. The patient was intubated and accepted as exitus despite cardiopulmonary resuscitation. Epistaxis is a very common onset symptom in AML. However, it is rarely remembered by otorhinolaryngologist. If a young patient without hypertension or other known systemic disease has severe epistaxis after a simple nose examination, blood count and peripheral blood smear must be requested absolutely. Otherwise, it may be too late for the patient, and mortality may be encountered in this case.

Keywords

References

Coombs CC, Tavakkoli M, Tallman MS. Acute promyelocytic leukemia: where did we start, where are we now, and the future. Blood Cancer J 2015; 5, e304.
Anak S, Uysalol E. Akut Miyeloid Lösemi (AML). J OF Pediatrics 2012; 12: 153-8.
Farrell AM, Gooptu C, Woodrow D, Costello C, Bunker CB, Cream JJ. Cutenous lymphatic vasculitis in acute myeloid leukemia. British J Dermatology 1996; 135: 471-4.
Swinnen S, van Heerden J, Uyttebroeck A, Boeckx N, Op de Beeck K, Casteels I. A child with bilateral proptosis: A sign of acute myeloid leukemia? J Pediatr Heamtol Oncol 2012; 34: 35-7.
Misuk J, Chi HS, Jang S, Park CJ, Lee JH, Seo JJ. Acute Promyelocytic Leukemia presenting with Central nervous system involvment: A report of 2 cases. Korean J Lab Med 2011; 31: 9-12.
Suriya OM, Aleem A. Frank hematuria as the presentation feature of acute leukemia. Saudi J Kidney Dis Transpl 2010; 21: 940-2.
Traboulsi H, Alam E, Hadi U. Changing Trends in the Management of Epistaxis. Int J Otolaryngol 2015; 7.
Akıner M, Beton S. Epistaksis. Ear Nose Throat Disease and Head Neck Surgery. Editor; Gerçeker M. Nobel Tıp Publishing, Ankara, 2014: 419-31.

Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Case Report

Authors

Fulya Özer
0000-0001-5381-6861
Türkiye

Soner Solmaz
0000-0002-1122-7839
Türkiye

Cüneyt Yılmazer
0000-0001-8397-0712
Türkiye

Publication Date

March 6, 2019

Submission Date

September 1, 2018

Acceptance Date

December 2, 2018

Published in Issue

Year 2018 Volume: 1 Number: 3

DOI

https://doi.org/10.5152/ejra.2019.37

IZ

https://izlik.org/JA92NF75WT

Cite

RIS / Bibtex

APA

Özer, F., Solmaz, S., & Yılmazer, C. (2019). The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis. European Journal of Rhinology and Allergy, 1(3), 73-75. https://doi.org/10.5152/ejra.2019.37

AMA

1.Özer F, Solmaz S, Yılmazer C. The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis. Eur J Rhinol Allergy. 2019;1(3):73-75. doi:10.5152/ejra.2019.37

Chicago

Özer, Fulya, Soner Solmaz, and Cüneyt Yılmazer. 2019. “The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis”. European Journal of Rhinology and Allergy 1 (3): 73-75. https://doi.org/10.5152/ejra.2019.37.

EndNote

Özer F, Solmaz S, Yılmazer C (March 1, 2019) The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis. European Journal of Rhinology and Allergy 1 3 73–75.

IEEE

[1]F. Özer, S. Solmaz, and C. Yılmazer, “The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis”, Eur J Rhinol Allergy, vol. 1, no. 3, pp. 73–75, Mar. 2019, doi: 10.5152/ejra.2019.37.

ISNAD

Özer, Fulya - Solmaz, Soner - Yılmazer, Cüneyt. “The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis”. European Journal of Rhinology and Allergy 1/3 (March 1, 2019): 73-75. https://doi.org/10.5152/ejra.2019.37.

JAMA

1.Özer F, Solmaz S, Yılmazer C. The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis. Eur J Rhinol Allergy. 2019;1:73–75.

MLA

Özer, Fulya, et al. “The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis”. European Journal of Rhinology and Allergy, vol. 1, no. 3, Mar. 2019, pp. 73-75, doi:10.5152/ejra.2019.37.

Vancouver

1.Fulya Özer, Soner Solmaz, Cüneyt Yılmazer. The First Symptom of Acute Myeloblastic Leukemia: Massive Epistaxis. Eur J Rhinol Allergy. 2019 Mar. 1;1(3):73-5. doi:10.5152/ejra.2019.37