Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study
Abstract
Background: Acute cough is one of the most frequent complaints in pediatric practice and significantly affects both children and their families. Due to safety concerns regarding conventional antitussive medications, interest in herbal therapies has increased.
Objective: To evaluate the efficacy, safety, and quality-of-life impact of a herbal cough syrup containing Grindelia, Plantago, and Helichrysum in children aged 10–12 years.
Methods: This prospective single-arm study included 120 children with acute cough. All participants received the herbal syrup for 7 days. Cough severity, pediatric and parental quality of life, parental satisfaction, and safety outcomes were assessed.
Results: Cough severity decreased significantly by Day 3 and Day 7 (p < 0.001). Both the child's and the parent's quality-of-life scores improved significantly. Parental satisfaction was high, and no serious adverse events were observed.
Conclusion: The herbal cough syrup demonstrated significant clinical effectiveness, excellent tolerability, and meaningful improvements in quality of life, supporting its use as a complementary therapy in pediatric cough management.
Keywords
Supporting Institution
N/A
Ethical Statement
Approved
References
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Details
Primary Language
English
Subjects
Otorhinolaryngology
Journal Section
Clinical Research
Publication Date
March 26, 2026
Submission Date
March 9, 2026
Acceptance Date
March 13, 2026
Published in Issue
Year 2026 Volume: 9 Number: 1
APA
Özdemir, E., & Yağcı, T. (2026). Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study. European Journal of Rhinology and Allergy, 9(1), 16-20. https://doi.org/10.65396/ejra.1905919
AMA
1.Özdemir E, Yağcı T. Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study. Eur J Rhinol Allergy. 2026;9(1):16-20. doi:10.65396/ejra.1905919
Chicago
Özdemir, Erdi, and Tarık Yağcı. 2026. “Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study”. European Journal of Rhinology and Allergy 9 (1): 16-20. https://doi.org/10.65396/ejra.1905919.
EndNote
Özdemir E, Yağcı T (March 1, 2026) Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study. European Journal of Rhinology and Allergy 9 1 16–20.
IEEE
[1]E. Özdemir and T. Yağcı, “Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study”, Eur J Rhinol Allergy, vol. 9, no. 1, pp. 16–20, Mar. 2026, doi: 10.65396/ejra.1905919.
ISNAD
Özdemir, Erdi - Yağcı, Tarık. “Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study”. European Journal of Rhinology and Allergy 9/1 (March 1, 2026): 16-20. https://doi.org/10.65396/ejra.1905919.
JAMA
1.Özdemir E, Yağcı T. Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study. Eur J Rhinol Allergy. 2026;9:16–20.
MLA
Özdemir, Erdi, and Tarık Yağcı. “Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study”. European Journal of Rhinology and Allergy, vol. 9, no. 1, Mar. 2026, pp. 16-20, doi:10.65396/ejra.1905919.
Vancouver
1.Erdi Özdemir, Tarık Yağcı. Investigation of the Effectiveness of Cough Syrup Containing Grindelia, Plantago, and Helichrysum in Relieving Cough Symptoms: A Prospective Single-Arm Study. Eur J Rhinol Allergy. 2026 Mar. 1;9(1):16-20. doi:10.65396/ejra.1905919